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3D-printing of engineered cartilage tissues
3D-printing of engineered cartilage tissues can provide a platform for in vitro drug testing as well as be applied for cartilage tissue repair. Various combination of biomaterials and nanoparticles would be studied for the generation of 3D printed engineered cartilage tissue.
Keywords: hydrogel, nanocomposite, 3D printing, cartilage tissue, polysaccharide
Articular cartilage tissue is mainly composed of collagen type II, various glycosaminoglycans (GAGs) and chondrocytes, which provide its intrinsic load-bearing function. In particular, the large amounts of negatively charged GAGs are effectively attracting water molecules and providing the cartilage tissue with high load tolerance. In this project, various combinations of biomaterials such as chondroitin sulfate, hyaluronic acid and collagen would be tested for the generation of cartilage tissue-mimicking hydrogel. In addition, nanoparticles would be added to polymer mixtures to improve mechanical strength and shear thinning properties for 3D printing. The mechanical and biological properties, and printability would be assessed.
Articular cartilage tissue is mainly composed of collagen type II, various glycosaminoglycans (GAGs) and chondrocytes, which provide its intrinsic load-bearing function. In particular, the large amounts of negatively charged GAGs are effectively attracting water molecules and providing the cartilage tissue with high load tolerance. In this project, various combinations of biomaterials such as chondroitin sulfate, hyaluronic acid and collagen would be tested for the generation of cartilage tissue-mimicking hydrogel. In addition, nanoparticles would be added to polymer mixtures to improve mechanical strength and shear thinning properties for 3D printing. The mechanical and biological properties, and printability would be assessed.
This project is aimed at development of 3D-printed engineered cartilage tissues.
This project is aimed at development of 3D-printed engineered cartilage tissues.