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Postdoc in Structural Biology by NMR
A postdoc position is available in the group of Stephan Grzesiek at the Biozentrum of the University of Basel. Our aim is to apply and develop modern NMR methods for obtaining structure, dynamics, and function information on biomacromolecules and their complexes.
Keywords: NMR, protein structure, dynamics, membrane proteins, GPCR, protein expression
You will be involved in one of our current projects, which encompass developments for the study of G protein coupled receptors [1], methods for effective isotope labeling in higher eukaryotic cells [2], cancer [3,4], and protein folding [5-8].
The technical equipment includes state-of-the art 900 MHz and 600 MHz high-resolution spectrometers with cryo and magic angle spinning probes, many other biophysical technologies and a protein expression lab. The group is embedded in the Focal Area “Structural Biology and Biophysics” of the Biozentrum, which offers a stimulating interdisciplinary environment and in-house availability of all methods of modern structural biology.
For further information please visit http://www.biozentrum.unibas.ch/grzesiek
**References**
[1] Isogai, S., Deupi, X., Opitz, C., Heydenreich, F. M., Tsai, C.-J., Brueckner, F., Schertler, G. F. X., Veprintsev, D. B., Grzesiek, S., Nature 2016, 530, 237–241.
[2] Opitz, C., Isogai, S., Grzesiek, S., J. Biomol. NMR 2015, 62, 373–385.
[3] Skora, L., Mestan, J., Fabbro, D., Jahnke, W., Grzesiek, S., Proc. Natl. Acad. Sci. USA 2013, 110, 4437–4445.
[4] Zhang, J., Adrián, F. J., Jahnke, W., Cowan-Jacob, S. W., Li, A. G., Iacob, R. E., Sim, T., Powers, J., Dierks, C., Sun, F., Guo, G.-R., Ding, Q., Okram, B., Choi, Y., Wojciechowski, A., Deng, X., Liu, G., Fendrich, G., Strauss, A., Vajpai, N., Grzesiek, S., Tuntland, T., Liu, Y., Bursulaya, B., Azam, M., Manley, P. W., Engen, J. R., Daley, G. Q., Warmuth, M., Gray, N. S., Nature 2010, 463, 501–506.
[5] Aznauryan, M., Delgado, L., Soranno, A., Nettels, D., Huang, J.-R., Labhardt, A. M., Grzesiek, S., Schuler, B., Proc. Natl. Acad. Sci. USA 2016, 113, E5389–E5398.
[6] Bignucolo, O., Leung, H. T. A., Grzesiek, S., Bernèche, S., J. Am. Chem. Soc. 2015, 137, 4300–4303.
[7] Vajpai, N., Nisius, L., Wiktor, M., Grzesiek, S., Proc. Natl. Acad. Sci. USA 2013, 110, E368–76.
[8] Nisius, L., Grzesiek, S., Nat Chem 2012, 4, 711–717.
You will be involved in one of our current projects, which encompass developments for the study of G protein coupled receptors [1], methods for effective isotope labeling in higher eukaryotic cells [2], cancer [3,4], and protein folding [5-8].
The technical equipment includes state-of-the art 900 MHz and 600 MHz high-resolution spectrometers with cryo and magic angle spinning probes, many other biophysical technologies and a protein expression lab. The group is embedded in the Focal Area “Structural Biology and Biophysics” of the Biozentrum, which offers a stimulating interdisciplinary environment and in-house availability of all methods of modern structural biology.
For further information please visit http://www.biozentrum.unibas.ch/grzesiek
**References** [1] Isogai, S., Deupi, X., Opitz, C., Heydenreich, F. M., Tsai, C.-J., Brueckner, F., Schertler, G. F. X., Veprintsev, D. B., Grzesiek, S., Nature 2016, 530, 237–241. [2] Opitz, C., Isogai, S., Grzesiek, S., J. Biomol. NMR 2015, 62, 373–385. [3] Skora, L., Mestan, J., Fabbro, D., Jahnke, W., Grzesiek, S., Proc. Natl. Acad. Sci. USA 2013, 110, 4437–4445. [4] Zhang, J., Adrián, F. J., Jahnke, W., Cowan-Jacob, S. W., Li, A. G., Iacob, R. E., Sim, T., Powers, J., Dierks, C., Sun, F., Guo, G.-R., Ding, Q., Okram, B., Choi, Y., Wojciechowski, A., Deng, X., Liu, G., Fendrich, G., Strauss, A., Vajpai, N., Grzesiek, S., Tuntland, T., Liu, Y., Bursulaya, B., Azam, M., Manley, P. W., Engen, J. R., Daley, G. Q., Warmuth, M., Gray, N. S., Nature 2010, 463, 501–506. [5] Aznauryan, M., Delgado, L., Soranno, A., Nettels, D., Huang, J.-R., Labhardt, A. M., Grzesiek, S., Schuler, B., Proc. Natl. Acad. Sci. USA 2016, 113, E5389–E5398. [6] Bignucolo, O., Leung, H. T. A., Grzesiek, S., Bernèche, S., J. Am. Chem. Soc. 2015, 137, 4300–4303. [7] Vajpai, N., Nisius, L., Wiktor, M., Grzesiek, S., Proc. Natl. Acad. Sci. USA 2013, 110, E368–76. [8] Nisius, L., Grzesiek, S., Nat Chem 2012, 4, 711–717.
Candidates need a PhD degree in biochemistry, physical chemistry, biophysics or a related scientific discipline and experience in one or several of the following areas: membrane biophysics, molecular biology or protein production with a background in structure, macromolecular NMR, or method development for solution or solid state NMR.
Applications should include cover letter, CV, and contact information of two references. Applications and informal queries about the lab and research projects should be directed by email to Prof. Stephan Grzesiek.
Prof. Stephan Grzesiek Biozentrum, University of Basel Klingelbergstrasse 70 CH-4056 Basel, Switzerland e-mail: stephan.grzesiek-at-unibas.ch http://www.biozentrum.unibas.ch/grzesiek
