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Design and Testing of an Optical Cell Concentration Sensor for Process Control in Biotechnology
In this project, you will design an optical sensor to measure the cell concentration in a fluid. The optical path length, electric components and the fluid flow in the sensor shall be optimized to achieve a high measurement accuracy.
Keywords: Sensor, PCB, Signal Acquisition, Biotechnology
At HPE, magnetically levitating separation methods for biotechnology and pharmaceutical applications are investigated.
Contactless rotation of centrifuges and spinfilters allow for high purity and sterile processes, simple device topologies, less cell damage, and higher long-term performance.
However, the separation efficiency of the investigated devices is variable with respect to the operation conditions and must be continuously monitored and controlled. Therefore, a precise in-line particle concentration measurement of the product stream is required to quantify the performance of these separation devices.
In this project, you will design a PCB for the electronic circuit and a 3D-printable sensor housing.
The sensor signal shall be integrated in the state-of-the-art bioprocessing equipment software environment.
You will build and test the sensor prototype with a model cell suspension in the laboratories of Levitronix in Altstetten, a leading supplier of process equipment for microelectronics, life sciences and industrial applications.
At HPE, magnetically levitating separation methods for biotechnology and pharmaceutical applications are investigated. Contactless rotation of centrifuges and spinfilters allow for high purity and sterile processes, simple device topologies, less cell damage, and higher long-term performance. However, the separation efficiency of the investigated devices is variable with respect to the operation conditions and must be continuously monitored and controlled. Therefore, a precise in-line particle concentration measurement of the product stream is required to quantify the performance of these separation devices.
In this project, you will design a PCB for the electronic circuit and a 3D-printable sensor housing. The sensor signal shall be integrated in the state-of-the-art bioprocessing equipment software environment. You will build and test the sensor prototype with a model cell suspension in the laboratories of Levitronix in Altstetten, a leading supplier of process equipment for microelectronics, life sciences and industrial applications.
Lars Beglinger, beglinger@hpe.ee.ethz.ch
Lars Beglinger, beglinger@hpe.ee.ethz.ch
40% Hardware Design
20% Coding
30% Testing
10% Theory
40% Hardware Design 20% Coding 30% Testing 10% Theory
Interest in interdisciplinary engineering challenges, Organized lab work
Interest in interdisciplinary engineering challenges, Organized lab work