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Body-on-a-chip: Automatization of 3D microtissue handling and analysis in microfluidic systems
3D spheroids are becoming increasingly important as in vitro models. Culturing them in microfluidic chips offers a wide variety of experimental applications. The project aims to automatize the experimental workflow with 3D spheroids in microfluidic chips, using sophisticated liquid handling robots.
Keywords: 3D microtissues, Spheroids, Microfluidics, Automation
Experimentation on 3D microtissues in a microfluidic chip will be automatized to the highest degree possible. Steps that are included in this workflow are chip preparation, microtissue loading and post-experimental analysis of microtissues and their supernatant. Further, drug efficacy and toxicity experiments will be performed automated and manually. Tasks consist of programming liquid handling robots in cooperation with our in-house lab automation facility, thorough validation of automated workflows and comparison to manual experimentation. All steps include the production, handling and maintaining of different types of 3D microtissues and their subsequent analysis including, but not limited to, biochemical assays.
For more info, see attached PDF file.
Experimentation on 3D microtissues in a microfluidic chip will be automatized to the highest degree possible. Steps that are included in this workflow are chip preparation, microtissue loading and post-experimental analysis of microtissues and their supernatant. Further, drug efficacy and toxicity experiments will be performed automated and manually. Tasks consist of programming liquid handling robots in cooperation with our in-house lab automation facility, thorough validation of automated workflows and comparison to manual experimentation. All steps include the production, handling and maintaining of different types of 3D microtissues and their subsequent analysis including, but not limited to, biochemical assays. For more info, see attached PDF file.
Automatization of 3D microtissue handling.
For more info, see attached PDF file.
Automatization of 3D microtissue handling. For more info, see attached PDF file.
- Christian Lohasz | Christian.lohasz@bsse.ethz.ch | +41 61 387 3128
- Dr. Kasper Renggli | Kasper.renggli@bsse.ethz.ch | +41 61 387 3238
- Dr. Daniel Meyer | Daniel.meyer@bsse.ethz.ch | +41 61 387 3413
- Christian Lohasz | Christian.lohasz@bsse.ethz.ch | +41 61 387 3128 - Dr. Kasper Renggli | Kasper.renggli@bsse.ethz.ch | +41 61 387 3238 - Dr. Daniel Meyer | Daniel.meyer@bsse.ethz.ch | +41 61 387 3413