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Debris of a feast: Analyzing leftovers after burst of pathogenic bacteria due to phages or predatory bacteria
Antibiotic resistance is one of the biggest threats to public health and alternatives to
conventional antibiotics are urgently needed. An innovative way to kill pathogenic bacteria
is to use their natural enemies bacteriophages or a periplasmic predatory
bacterium (Bdellovibrio bacteriovorus). While the detrimental destruction of pathogenic
bacteria can be an advantage to stimulate the immune response of the infected eukaryote,
too much immune stimulation may lead to toxic shock.
Methods you will learn: Laboratory work with a predatory bacterium (Bdellovibrio bacteriovorus), different
bacteriophages, Escherichia coli and pathogenic bacteria (depending on progress). Lab works
includes microscopy. Specific determination and quantification of protein content, DNA
content, as well as metabolomics in collaboration with FGCZ.
Methods you will learn: Laboratory work with a predatory bacterium (Bdellovibrio bacteriovorus), different bacteriophages, Escherichia coli and pathogenic bacteria (depending on progress). Lab works includes microscopy. Specific determination and quantification of protein content, DNA content, as well as metabolomics in collaboration with FGCZ.
This Master thesis project aims to determine what and how much soluble metabolites are
released when the pathogenic bacteria burst due to killing by phages or predatory bacteria.
This Master thesis project aims to determine what and how much soluble metabolites are released when the pathogenic bacteria burst due to killing by phages or predatory bacteria.
Interested? Please contact simona.huwiler@uzh.ch with your CV as well as track record and your background/why you are interested in that position. Unfortunately, for this position we can not offer any salary.
Interested? Please contact simona.huwiler@uzh.ch with your CV as well as track record and your background/why you are interested in that position. Unfortunately, for this position we can not offer any salary.
MSc_Metabolomics_Project.pdf
