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Whole-body imaging of mice using scanning volumetric optoacoustic tomography
Real-time visualization of vascular structures and tracking fast kinetics on a large scale in small animals is crucial for pharmacokinetics and perfusion studies, drug delivery, and so on. We aim to design MATLAB GUI for whole-body imaging of mouse using scanning volumetric optoacoustic tomography.
Small animal models are extensively used in biomedical research for studying human disease progression and monitoring responses to therapies. Over the past few decades, optoacoustic/photoacoustic tomography (OAT/PAT) has been gaining prominence in preclinical and clinical research as it uniquely combines the spectral sensitivity and contrast of optical imaging with high spatial resolution provided by ultrasound. Additionally, OAT systems have recently been advanced to enable 2D or 3D imaging of limited areas at frame rates of hundreds to thousands of Hertz. Tracking of biodynamics across entire living organisms is essential for understanding complex biology and disease progression. Small-animal OAT scanners based on different acquisition geometries are increasingly exploited in various biological applications. Whole-body tomographic imaging of mice is typically achieved via scanning of ultrasound arrays with the imaging speed and image quality mainly determined by the array configuration and scanning geometry.
Real-time visualization of vascular structures and tracking fast kinetics on a large scale is crucial for pharmacokinetics and perfusion studies, accelerated drug discovery, and optimizing the administration routes for effective treatment of diseases.
Small animal models are extensively used in biomedical research for studying human disease progression and monitoring responses to therapies. Over the past few decades, optoacoustic/photoacoustic tomography (OAT/PAT) has been gaining prominence in preclinical and clinical research as it uniquely combines the spectral sensitivity and contrast of optical imaging with high spatial resolution provided by ultrasound. Additionally, OAT systems have recently been advanced to enable 2D or 3D imaging of limited areas at frame rates of hundreds to thousands of Hertz. Tracking of biodynamics across entire living organisms is essential for understanding complex biology and disease progression. Small-animal OAT scanners based on different acquisition geometries are increasingly exploited in various biological applications. Whole-body tomographic imaging of mice is typically achieved via scanning of ultrasound arrays with the imaging speed and image quality mainly determined by the array configuration and scanning geometry. Real-time visualization of vascular structures and tracking fast kinetics on a large scale is crucial for pharmacokinetics and perfusion studies, accelerated drug discovery, and optimizing the administration routes for effective treatment of diseases.
The main goal of this project is to design a GUI using MATLAB that can (i)perform scanning/motion of the ultrasound array synchronized with laser trigger, (ii)display individual reconstructed frames in real-time during overfly scanning of the array, (iii)save the acquired data, and (iv) display final reconstructed volume of whole-body of mouse.
The main goal of this project is to design a GUI using MATLAB that can (i)perform scanning/motion of the ultrasound array synchronized with laser trigger, (ii)display individual reconstructed frames in real-time during overfly scanning of the array, (iii)save the acquired data, and (iv) display final reconstructed volume of whole-body of mouse.
Please send a brief introduction and your CV to Dr. Sandeep Kumar Kalva(sandeep.kalva@pharma.uzh.ch) and Prof. Daniel Razansky (danir@ethz.ch).
Please send a brief introduction and your CV to Dr. Sandeep Kumar Kalva(sandeep.kalva@pharma.uzh.ch) and Prof. Daniel Razansky (danir@ethz.ch).