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Pulsatile flow test bench for cellular studies
Development of a pulsatile flow test bench for in-vitro studies on endothelial cells
Von Willebrand Factor (vWF) is a large protein that plays an important role in blood clotting. It is secreted by endothelial cells (EC) into the blood stream, a process that is influenced among other factors by the strain and shear stress acting on the EC. Quantitative analyses of these impacts, however, are missing. A detailed study of these effects in vitro requires a flow driving system that is able to reproduce complex pulsatile flow profiles.
In this project, a test bench is to be developed which allows the generation of accurately controllable pulsatile flows for studies on endothelial cells. The envisioned system should enable both steady and transient flows, ranging from simple sinus waveforms to more complex physiological profiles.
The project presents the opportunity of experiencing and driving the complete development process, including the design of a suitable concept for the test bench, selection and assembly of the hardware and the implementation of needed control systems. Initial operations and validations of the system will provide a satisfying end goal.
Von Willebrand Factor (vWF) is a large protein that plays an important role in blood clotting. It is secreted by endothelial cells (EC) into the blood stream, a process that is influenced among other factors by the strain and shear stress acting on the EC. Quantitative analyses of these impacts, however, are missing. A detailed study of these effects in vitro requires a flow driving system that is able to reproduce complex pulsatile flow profiles. In this project, a test bench is to be developed which allows the generation of accurately controllable pulsatile flows for studies on endothelial cells. The envisioned system should enable both steady and transient flows, ranging from simple sinus waveforms to more complex physiological profiles. The project presents the opportunity of experiencing and driving the complete development process, including the design of a suitable concept for the test bench, selection and assembly of the hardware and the implementation of needed control systems. Initial operations and validations of the system will provide a satisfying end goal.
Literature research to further define the requirements and find suitable concepts
Concept development, assembly of system and implementation of controls
Initial operation and validation of achieved behavior
Literature research to further define the requirements and find suitable concepts Concept development, assembly of system and implementation of controls Initial operation and validation of achieved behavior
Basic knowledge of fluid dynamics Basic experience in control system development Strong motivation to work in an interdisciplinary field Ability to work independently and reliably Systematic and methodical approach to problems
The Interface Group addresses clinical needs through the convergence of engineering, biological, and medical research. pd¦z focuses on human-centered product development and promotes the continuous transfer of knowledge through cooperation.
We both regard the link between research and education as the key to excellence in training. With this interdisciplinary venture, we wish to promote collaboration to strengthen the competitiveness of biomechanical engineering industry.
The Interface Group addresses clinical needs through the convergence of engineering, biological, and medical research. pd¦z focuses on human-centered product development and promotes the continuous transfer of knowledge through cooperation. We both regard the link between research and education as the key to excellence in training. With this interdisciplinary venture, we wish to promote collaboration to strengthen the competitiveness of biomechanical engineering industry.