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Drug Screening with 3D Bioprinted Tissue Constructs
In this thesis, we aim to harness the latest advancements in 3D bioprinting of tissue constructs for drug screening applications. Our focus is on evaluating drug efficacy in custom-built bioprinted tissue constructs, and comparing these with microfluidics, organoids, and spheroid-based drug screening methods. By integrating state-of-the-art bioprinting technologies and novel bioinks, this project aims to create biomimetic tissues that can better mimic human tissue thus significantly enhancing drug screening processes. The research will involve the design of drug screening constructs, the testing of various drugs, and the analysis and comparison to traditional methods. Furthermore, we will explore possibilities to improve the construct design to produce more human-mimetic tissues, thereby enhancing human relevance and optimizing outputs. This will offer a more accurate and efficient platform for pharmacological testing and toxicity analysis.
Keywords: 3D bioprinting, drug screening, tissue constructs, pharmacological testing, biomimetics, tissue engineering, biomimetic design.
Join our pioneering team to transform pharmacology through the power of 3D bioprinting. This project leverages cutting-edge bioprinting technology to develop and analyze human-mimetic bioprinted tissue models for drug screening. In collaboration with Roche Pharmaceuticals, you will contribute to designing tissue constructs that replicate human organ functionalities, enhancing the predictive accuracy of drug responses. This work bridges the gap between traditional 2D cell cultures and in vivo studies, providing faster, safer, and more ethical drug testing methods.
Role of the Applicant:
As a Master's candidate, you will focus on testing bioprinted constructs for drug efficacy across various drug types. You will compare these results to traditional drug screening methods such as microfluidics, spheroids, and organoids. Additionally, you will collaborate with a multidisciplinary team to design bioink formulations for bioprinting specific tissues, aiming to achieve high-fidelity tissue models. Your role includes designing experiments, conducting pharmacological analyses, and assessing the bioactivity and toxicity of various compounds on the printed tissues. Collaboration with Prof. Markus Rimann, Roche Pharmaceuticals, and other team members will be crucial to integrating biological, chemical, and engineering perspectives to enhance the functionality of the bioprinted constructs.
Project Environment and Opportunities:
You will work in a dynamic, interdisciplinary environment equipped with advanced bioprinting facilities. This project offers a unique blend of engineering, biology, and pharmacology, providing extensive training and research opportunities in tissue engineering and regenerative medicine. It is an excellent opportunity for those eager to impact future medical practices and drug development strategies.
Join our pioneering team to transform pharmacology through the power of 3D bioprinting. This project leverages cutting-edge bioprinting technology to develop and analyze human-mimetic bioprinted tissue models for drug screening. In collaboration with Roche Pharmaceuticals, you will contribute to designing tissue constructs that replicate human organ functionalities, enhancing the predictive accuracy of drug responses. This work bridges the gap between traditional 2D cell cultures and in vivo studies, providing faster, safer, and more ethical drug testing methods.
Role of the Applicant:
As a Master's candidate, you will focus on testing bioprinted constructs for drug efficacy across various drug types. You will compare these results to traditional drug screening methods such as microfluidics, spheroids, and organoids. Additionally, you will collaborate with a multidisciplinary team to design bioink formulations for bioprinting specific tissues, aiming to achieve high-fidelity tissue models. Your role includes designing experiments, conducting pharmacological analyses, and assessing the bioactivity and toxicity of various compounds on the printed tissues. Collaboration with Prof. Markus Rimann, Roche Pharmaceuticals, and other team members will be crucial to integrating biological, chemical, and engineering perspectives to enhance the functionality of the bioprinted constructs.
Project Environment and Opportunities:
You will work in a dynamic, interdisciplinary environment equipped with advanced bioprinting facilities. This project offers a unique blend of engineering, biology, and pharmacology, providing extensive training and research opportunities in tissue engineering and regenerative medicine. It is an excellent opportunity for those eager to impact future medical practices and drug development strategies.
Advance drug screening by developing bioprinted tissue constructs that accurately mimic human organs, improving drug response predictions.
Objectives:
1. Develop Tissue Constructs: Create bioprinted tissues using advanced bioprinting technologies and novel bioinks.
2. Evaluate Drug Efficacy: Test various drugs on bioprinted tissues and compare results with traditional methods.
3. Optimize Bioinks: Collaborate with multidisciplinary teams, including Prof. Markus Rimann, and Roche Pharmaceuticals, to refine bioink formulations.
4. Design Experiments: Conduct experiments to assess bioactivity and toxicity of different compounds on bioprinted tissues.
5. Integrate Knowledge: Work with experts from biology, chemistry, and engineering to enhance tissue constructs.
6. Promote Ethical Testing: Use bioprinted tissues to reduce reliance on animal testing.
8. Improve Drug Development: Enhance medical practices and drug development with accurate and efficient drug testing platforms.
Advance drug screening by developing bioprinted tissue constructs that accurately mimic human organs, improving drug response predictions.
Objectives: 1. Develop Tissue Constructs: Create bioprinted tissues using advanced bioprinting technologies and novel bioinks. 2. Evaluate Drug Efficacy: Test various drugs on bioprinted tissues and compare results with traditional methods. 3. Optimize Bioinks: Collaborate with multidisciplinary teams, including Prof. Markus Rimann, and Roche Pharmaceuticals, to refine bioink formulations. 4. Design Experiments: Conduct experiments to assess bioactivity and toxicity of different compounds on bioprinted tissues. 5. Integrate Knowledge: Work with experts from biology, chemistry, and engineering to enhance tissue constructs. 6. Promote Ethical Testing: Use bioprinted tissues to reduce reliance on animal testing. 8. Improve Drug Development: Enhance medical practices and drug development with accurate and efficient drug testing platforms.
Please send your CV and transcript of records to Prajwal Agrawal: pprajwal@ethz.ch and Prof. Dr. Daniel Ahmed: dahmed@ethz.ch
Acoustic Robotics Systems Lab. Department of Mechanical and Process Engineering (D-MAVT). RSA G 324, Säumerstrasse 4, 8803 Rüschlikon, Switzerland.
Please send your CV and transcript of records to Prajwal Agrawal: pprajwal@ethz.ch and Prof. Dr. Daniel Ahmed: dahmed@ethz.ch Acoustic Robotics Systems Lab. Department of Mechanical and Process Engineering (D-MAVT). RSA G 324, Säumerstrasse 4, 8803 Rüschlikon, Switzerland.
