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Characterization of a chromatographic separation as a unit of an integrated continuous process
The main goal of the project is to investigate the SMB separation and to assess its performance, by characterizing the adsorption behavior of the desired compound on the chosen stationary phase and by defining the operating conditions for the separation by means of the triangle theory.
The work will start with an extended literature review about design and operation of SMB separations, then the adsorption isotherm will be determined, and the separation will be run at different operating conditions, i.e. with and without the recycle stream. The experimental results will be compared with the once obtain from the process simulation, and the separation performance will be evaluated in terms of purity, productivity, and solvent consumption. In view of the integration of the SMB unit in a more complex process, the project will focus on understanding how the presence of the recycle stream influences the separation, by varying the composition and the concentration of the feed, and on assessing the separation performance at different conditions.
The work will start with an extended literature review about design and operation of SMB separations, then the adsorption isotherm will be determined, and the separation will be run at different operating conditions, i.e. with and without the recycle stream. The experimental results will be compared with the once obtain from the process simulation, and the separation performance will be evaluated in terms of purity, productivity, and solvent consumption. In view of the integration of the SMB unit in a more complex process, the project will focus on understanding how the presence of the recycle stream influences the separation, by varying the composition and the concentration of the feed, and on assessing the separation performance at different conditions.
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