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Modeling and Control of an Ex Vivo Perfusion Machine

The reintegration of individuals who have experienced accidents is at the heart of our efforts. A severe car accident or a workplace accident, can profoundly change a person's life. Such tragic events often result in serious injuries, such as severed limbs, and are classified as "polytrauma." At our lab, we are working to mitigate the consequences of such severe accidents. Using an innovative perfusion machine, we are try to keep severed limbs alive outside the body for up to four days. This time window provides the foundation for successfully retransplanting the limb to a stabilized polytrauma patient.

Keywords: Mathematical modeling; Control; Biomedical

  • In your Semester Thesis, you will develop a mathematical model of the perfusion machine, which will be used to test new control algorithms in simulation. To gather the necessary data for the mathematical model you will run you own experiments on the perfusion machine testbench and get the opportunity to collaborate together with an entire team of dedicated and experienced researchers from USZ and the IDSC group. Prerequisites: Willingness to go the extra mile and to work on a medical topic. Working experience with MATLAB and SIMULINK is a must. Good project management skills, proactive initiative, and pleasure to work as a team.

    In your Semester Thesis, you will develop a
    mathematical model of the perfusion machine, which will
    be used to test new control algorithms in simulation. To
    gather the necessary data for the mathematical model
    you will run you own experiments on the perfusion
    machine testbench and get the opportunity to
    collaborate together with an entire team of dedicated and
    experienced researchers from USZ and the IDSC group.

    Prerequisites:
    Willingness to go the extra mile and to work on a medical topic. Working experience with
    MATLAB and SIMULINK is a must.
    Good project management skills, proactive initiative, and pleasure to work as a team.

  • Derive a mathematical model and a corresponding MIMO controller for the perfusion machine.

    Derive a mathematical model and a corresponding MIMO controller for the perfusion machine.

  • Dr. David Machacek davidm@ethz.ch

    Dr. David Machacek
    davidm@ethz.ch

Calendar

Earliest start2025-02-03
Latest end2025-12-23

Location

Research Onder (ETHZ)

Labels

Semester Project

Master Thesis

ETH Zurich (ETHZ)

Topics

  • Engineering and Technology
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