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In Silico micro-Multiphysics Agent-Based Modelling of Bone Regeneration and Adaptation
Develop and test a micro-Multiphysics Agent-Based (micro-MPA) model to simulate cellular interactions and mechanical stimuli during bone regeneration and adaptation.
Keywords: In silico, agent-based, computational, bone regeneration, bone adaptation, simulation
Bone regeneration is a critical process in maintaining skeletal integrity, particularly in response to fractures and surgical interventions. Bone tissue continuously undergoes remodelling through the coordinated activity of bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts), as well as the regulatory role of osteocytes, which sense local mechanical stimuli and mediate cellular responses. This process ensures that bone structure adapts dynamically to mechanical stress and maintains its strength and density.
In conditions such as bone injuries or disorders like osteoporosis, the natural balance between bone resorption and bone formation is disrupted. Promoting bone regeneration and restoring normal bone remodelling processes are essential for ensuring the proper recovery of skeletal tissue. However, the exact biological mechanisms driving bone regeneration are not fully understood.
_In silico_ **micro-Multiphysics Agent-Based (micro-MPA)** models offer a powerful approach to study bone regeneration and remodelling at the cellular level. These computational models allow the simulation of cellular behaviors, biochemical signaling, and mechanical stimuli that occur during bone regeneration. By combining multiphysics with agent-based simulations, the micro-MPA model simulates various aspects of bone remodelling, providing valuable insights into the efficacy of potential treatments or interventions for bone regeneration and/or homeostasis.
This project will focus on testing and expanding an _in silico_ micro-Multiphysics Agent-Based model for simulating bone regeneration and adaptation. The model will simulate the dynamic interactions of many cell types during the healing and remodelling process. The project will include a thorough review of current research on bone regeneration mechanisms and the role of mechanical stimuli in the process. The model will be validated against available experimental data, particularly focusing on the morphometry of the mineralised tissue. The goal is to investigate the potential mechanisms involved in bone regeneration and/or adaptation and identify factors that may optimise or attenuate this process.
Bone regeneration is a critical process in maintaining skeletal integrity, particularly in response to fractures and surgical interventions. Bone tissue continuously undergoes remodelling through the coordinated activity of bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts), as well as the regulatory role of osteocytes, which sense local mechanical stimuli and mediate cellular responses. This process ensures that bone structure adapts dynamically to mechanical stress and maintains its strength and density.
In conditions such as bone injuries or disorders like osteoporosis, the natural balance between bone resorption and bone formation is disrupted. Promoting bone regeneration and restoring normal bone remodelling processes are essential for ensuring the proper recovery of skeletal tissue. However, the exact biological mechanisms driving bone regeneration are not fully understood.
_In silico_ **micro-Multiphysics Agent-Based (micro-MPA)** models offer a powerful approach to study bone regeneration and remodelling at the cellular level. These computational models allow the simulation of cellular behaviors, biochemical signaling, and mechanical stimuli that occur during bone regeneration. By combining multiphysics with agent-based simulations, the micro-MPA model simulates various aspects of bone remodelling, providing valuable insights into the efficacy of potential treatments or interventions for bone regeneration and/or homeostasis.
This project will focus on testing and expanding an _in silico_ micro-Multiphysics Agent-Based model for simulating bone regeneration and adaptation. The model will simulate the dynamic interactions of many cell types during the healing and remodelling process. The project will include a thorough review of current research on bone regeneration mechanisms and the role of mechanical stimuli in the process. The model will be validated against available experimental data, particularly focusing on the morphometry of the mineralised tissue. The goal is to investigate the potential mechanisms involved in bone regeneration and/or adaptation and identify factors that may optimise or attenuate this process.
Not specified
Jack Kendall, Doctoral Candidate
jack.kendall@hest.ethz.ch
n.ethz.ch/~kendallj
Jack Kendall, Doctoral Candidate jack.kendall@hest.ethz.ch n.ethz.ch/~kendallj
