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Development of a Fiber-Based Optoacoustic Microscope
Optoacoustic microscopy can image vasculature with single capillary resolution in 3D and at depth. This new imaging approach holds great potential to provide better insights into cerebrovascular function and facilitate efficient studies into neurological and vascular abnormalities of the brain.
Optoacoustic microscopy has shown great potential for visualization of brain vasculature in mice. When combined with a multi-spectral excitation, i.e. the use of more than one wavelength, functional parameters such as blood-oxygenation can be visualized in the entire cortex without additional contrast agents. Our group has developed an optoacoustic microscope system with such a dual-wavelength approach (see Rebling et al., J Biophotonics 2018). However, existing solutions relied on complicated, expensive and difficult to use free-beam optics. In order to create an easy to use, fast and reliable multi-wavelength optoacoustic microscope, we would like to develop a fiber-based optical excitation.
Optoacoustic microscopy has shown great potential for visualization of brain vasculature in mice. When combined with a multi-spectral excitation, i.e. the use of more than one wavelength, functional parameters such as blood-oxygenation can be visualized in the entire cortex without additional contrast agents. Our group has developed an optoacoustic microscope system with such a dual-wavelength approach (see Rebling et al., J Biophotonics 2018). However, existing solutions relied on complicated, expensive and difficult to use free-beam optics. In order to create an easy to use, fast and reliable multi-wavelength optoacoustic microscope, we would like to develop a fiber-based optical excitation.
The student is expected to help build a multi-wavelength, fiber based optoacoustic microscope based on partially existing hardware. This requires the processing of optical fibers, testing and application of these fibers. A background in applied physics, photonics, electrical or biomedical engineering, and experience with basci optical setups is required. Experience in programming (MATLAB, Python) and hardware interfacing or mechatronics would be an advantage. The project should last at least 3 months.
The student is expected to help build a multi-wavelength, fiber based optoacoustic microscope based on partially existing hardware. This requires the processing of optical fibers, testing and application of these fibers. A background in applied physics, photonics, electrical or biomedical engineering, and experience with basci optical setups is required. Experience in programming (MATLAB, Python) and hardware interfacing or mechatronics would be an advantage. The project should last at least 3 months.
Please send your application as a single PDF including cover letter, CV, grades and references to jrebling@student.ethz.ch.
Please send your application as a single PDF including cover letter, CV, grades and references to jrebling@student.ethz.ch.