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Histological assessment of mechanical loading in naturally aging mice
Several animal loading models exist to study the effect of mechanical loading on bone remodeling and regeneration. Our group has previously developed a mouse model to cyclically load the sixth caudal vertebrae. However, the effect of this particular loading protocol on bone adaptation during aging has not yet been investigated.
The PolgA mice exhibit a naturally accelerated aging phenotype developing premature onset of clinically-relevant musculoskeletal aging characteristics, including frailty and kyphosis. However, the relevance of this model to understand the responsible mechanism of age and sex associated changes upon mechanical loading remains unclear.
The PolgA mice exhibit a naturally accelerated aging phenotype developing premature onset of clinically-relevant musculoskeletal aging characteristics, including frailty and kyphosis. However, the relevance of this model to understand the responsible mechanism of age and sex associated changes upon mechanical loading remains unclear.
This project aims to establish and apply protocols for histological analysis of murine bone tissue in order to investigate the age and sex related differences upon mechanical loading.
Particularly students with interest and experience in biology and biomedical engineering are encouraged to apply.
This project aims to establish and apply protocols for histological analysis of murine bone tissue in order to investigate the age and sex related differences upon mechanical loading. Particularly students with interest and experience in biology and biomedical engineering are encouraged to apply.
Dilara Yilmaz, dilara.yilmaz@hest.ethz.ch, Institute for Biomechanics, ETH Zurich, Professorship Ralph Muller
Dilara Yilmaz, dilara.yilmaz@hest.ethz.ch, Institute for Biomechanics, ETH Zurich, Professorship Ralph Muller
