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Microrobot manipulation in brain tumor model
We want to expand the use of acoustic microrobots for drug delivery biomedical applications in brain tumor environments of small mammalian models.
Keywords: Drug delivery, Microrobots, Ultrasounds
This project will study the acoustic manipulation of bubble based microrobots in real vasculature. A mice model of a glioblastoma will be created, and 3D manipulation of the microrobots will be characterized.
This project will study the acoustic manipulation of bubble based microrobots in real vasculature. A mice model of a glioblastoma will be created, and 3D manipulation of the microrobots will be characterized.
The goal of this project is to analyze the performance of acoustic microswarms as drug delivery carriers for tumor treatment applications. We will exploit the nature of cancer tissue by specifically targeting irregular, leaky vascularization. The student should be willing to assist experiments in-vivo. No previous knowledge is needed, full guidance by a PhD will be provided.
- First, a set-up to bring the acoustic signal to the mice will be designed
- Initial experiments will be performed to analyze the efficiency of microrobot actuation when inside in-vivo vasculature.
- Microrobots will be visualized with 2-photon microscope and ultrasound imaging.
- Experiments will be performed in different anatomical locations, efficiency and limitations at each place will be studied.
- As final step, microrobots will be loaded with drugs, and drug delivery will be studied to the different disease locations.
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Your Profile
Background in Biology, Biomedical Engineering, Mechanical Engineering, Material Science, Chemical Engineering, Chemistry, or related fields
No inconvenience working with in-vivo mice models.
Independent student with critical thinking and problem solving skills
Can gather data from experiments and present them hem using different charts such as boxplot and scatter plots
The goal of this project is to analyze the performance of acoustic microswarms as drug delivery carriers for tumor treatment applications. We will exploit the nature of cancer tissue by specifically targeting irregular, leaky vascularization. The student should be willing to assist experiments in-vivo. No previous knowledge is needed, full guidance by a PhD will be provided.
- First, a set-up to bring the acoustic signal to the mice will be designed - Initial experiments will be performed to analyze the efficiency of microrobot actuation when inside in-vivo vasculature. - Microrobots will be visualized with 2-photon microscope and ultrasound imaging. - Experiments will be performed in different anatomical locations, efficiency and limitations at each place will be studied. - As final step, microrobots will be loaded with drugs, and drug delivery will be studied to the different disease locations.
- Your Profile
Background in Biology, Biomedical Engineering, Mechanical Engineering, Material Science, Chemical Engineering, Chemistry, or related fields
No inconvenience working with in-vivo mice models.
Independent student with critical thinking and problem solving skills
Can gather data from experiments and present them hem using different charts such as boxplot and scatter plots
Alexia Del Campo (afonseca@student.ethz.ch) Acoustic Robotics Systems Lab. Department of Mechanical and Process Engineering (D-MAVT). RSA G 324, Säumerstrasse 4, 8803 Rüschlikon, Switzerland. Website: https://arsl.ethz.ch/
Alexia Del Campo (afonseca@student.ethz.ch) Acoustic Robotics Systems Lab. Department of Mechanical and Process Engineering (D-MAVT). RSA G 324, Säumerstrasse 4, 8803 Rüschlikon, Switzerland. Website: https://arsl.ethz.ch/