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On-chip Mechanical Stimulation to Dissect Bone Mechanobiology
A fundamental question in bone biology is how osteocytes magnify tissue-level mechanical strains to cell-level strains to elicit a biochemical response. This project aims to develop a tool for on-chip mechanical stimulation of 3D hydrogels to study signal transduction in osteocyte mechanosensation.
Keywords: on-chip, microfluidics, 3D cell culture, bone mechanobiology, hydrogels
Not specified
The goal of this project is to develop a novel on-chip mechanical loading device to address exciting questions in bone mechanobiology. We seek to cultivate living bone cells in a dynamic 3D environment. Next, fundamental questions related to how bone cells detect and respond to biomechanical stimuli by mechanical loading will be investigated using on-chip mechanical stimulation and live-cell imaging technique.
The goal of this project is to develop a novel on-chip mechanical loading device to address exciting questions in bone mechanobiology. We seek to cultivate living bone cells in a dynamic 3D environment. Next, fundamental questions related to how bone cells detect and respond to biomechanical stimuli by mechanical loading will be investigated using on-chip mechanical stimulation and live-cell imaging technique.
Doris Zauchner (doris.zauchner@hest.ethz.ch), PhD candidate; and Dr. Xiao-Hua Qin(qinx@ethz.ch), Senior Scientist & Team Lead, Laboratory for
Bone Biomechanics, ETH Zürich
Candidates with an engineering background and particular interests (or prior experiences) in on-chip technology, cell culture, cell imaging will be preferably considered.
For application, please submit your CV, Transcripts of B.Sc. and M.Sc., contacts of 2 references.
Doris Zauchner (doris.zauchner@hest.ethz.ch), PhD candidate; and Dr. Xiao-Hua Qin(qinx@ethz.ch), Senior Scientist & Team Lead, Laboratory for Bone Biomechanics, ETH Zürich
Candidates with an engineering background and particular interests (or prior experiences) in on-chip technology, cell culture, cell imaging will be preferably considered.
For application, please submit your CV, Transcripts of B.Sc. and M.Sc., contacts of 2 references.
