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Establishing Volumetrically Bioprinted Human In Vitro Bone Organoid Models
Laboratory-grown miniature bones (organoids) can facilitate the investigation of the biology in healthy and diseased human bone, thereby replacing animal experiments and providing a mechanistic understanding of bone remodeling. The goal of this research is to establish an in vitro technique for volumetric 3D bioprinting of structurally complex human bone organoids. This bone organoid has the potential to enable studying human bone remodeling in the laboratory without the need for animal models.
Keywords: volumetric bioprinting, hydrogels, bone tissue engineering, bone remodeling
Advances in 3D bioprinting have enabled the embedding of cells into structurally complex hydrogel constructs. Conventional extrusion bioprinting relies on a layer-by-layer process, which often is slow and may induce high shear stress to cells, thereby impairing their functionality. To address these limits, volumetric bioprinting (VBP) has recently emerged as a promising tool for fabrication of structurally complex cell-laden hydrogels within tens of seconds by photo crosslinking. Here, we aim at optimizing the application of this technique for the development of in vitro bone organoid models that could facilitate the investigation of human bone diseases while reducing the need for animal experiments.
Advances in 3D bioprinting have enabled the embedding of cells into structurally complex hydrogel constructs. Conventional extrusion bioprinting relies on a layer-by-layer process, which often is slow and may induce high shear stress to cells, thereby impairing their functionality. To address these limits, volumetric bioprinting (VBP) has recently emerged as a promising tool for fabrication of structurally complex cell-laden hydrogels within tens of seconds by photo crosslinking. Here, we aim at optimizing the application of this technique for the development of in vitro bone organoid models that could facilitate the investigation of human bone diseases while reducing the need for animal experiments.
The goal of this research is to develop a biomanufacturing technique for structurally complex human bone organoids. To establish this human bone organoid, volumetric bioprinting, biomaterial sciences and advanced cell culture techniques.
The goal of this research is to develop a biomanufacturing technique for structurally complex human bone organoids. To establish this human bone organoid, volumetric bioprinting, biomaterial sciences and advanced cell culture techniques.
Dr. Bregje de Wildt (bregje.dewildt@hest.ethz.ch), postdoc; and Dr. Xiao-Hua Qin (qinx@ethz.ch), Senior Scientist and Team Lead, Laboratory for Bone Biomechanics, ETH Zürich. For application, please submit your CV and Transcripts of B.Sc. and M.Sc..
Dr. Bregje de Wildt (bregje.dewildt@hest.ethz.ch), postdoc; and Dr. Xiao-Hua Qin (qinx@ethz.ch), Senior Scientist and Team Lead, Laboratory for Bone Biomechanics, ETH Zürich. For application, please submit your CV and Transcripts of B.Sc. and M.Sc..
