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Development of an acoustic source model to simulate medical focused ultrasound
High-intensity focused ultrasound (HIFU) is a non-invasive clinical procedure with a wide range of medical applications, such as body tissue ablation or drug delivery, to name but a few. Simulating such acoustic fields, in interaction with fluids, is of major importance for the research community.
Keywords: Numerical models and methods, CFD, acoustics, bubbles
High-intensity focused ultrasound (HIFU) is a non-invasive clinical procedure with a wide range of medical applications, such as body tissue ablation or drug delivery, to name but a few. Of particular interest is the response of bubble, and bubble clouds, to such an excitation source. One-way acoustic source models have already been developed to simulate HIFUs, which enables to investigate complex phenomena such as the energy shielding processes resulting in the anisotropic structure of the cloud [https://doi.org/10.1017/jfm.2018.968]. However, such codes do not yet allow for the tissue modelling and the fluid/structure interaction, thus being limited to fluid dynamic considerations.
High-intensity focused ultrasound (HIFU) is a non-invasive clinical procedure with a wide range of medical applications, such as body tissue ablation or drug delivery, to name but a few. Of particular interest is the response of bubble, and bubble clouds, to such an excitation source. One-way acoustic source models have already been developed to simulate HIFUs, which enables to investigate complex phenomena such as the energy shielding processes resulting in the anisotropic structure of the cloud [https://doi.org/10.1017/jfm.2018.968]. However, such codes do not yet allow for the tissue modelling and the fluid/structure interaction, thus being limited to fluid dynamic considerations.
In this project, an acoustic source model shall be implemented in the open-source code ECOGEN [https://doi.org/10.1016/j.cpc.2019.107093]. Among other, this code has been developed to simulate bubble/structure interactions, which is of primary interest for the research activities of the Lab. Modelling efforts will be eventually assessed against experiments. More specifically, the project is composed of the following tasks:
1. Getting familiar with the numerical models and methods implemented in ECOGEN, and literature review about acoustic source models dedicated to ultrasound and HIFU.
2. Implement an acoustic source model in ECOGEN for simulating (high-intensity) unfocused, focused and diverging ultrasound beam operating over the kHz-MHz range.
3. Validate the modelling against experimental measurements available in the literature and data from the Lab.
4. Run experimental test case(s) to assess the performance of numerical model for simulating HIFU/bubble(s) interactions.
5. Documentation and presentation of the project results and acoustic source model
In this project, an acoustic source model shall be implemented in the open-source code ECOGEN [https://doi.org/10.1016/j.cpc.2019.107093]. Among other, this code has been developed to simulate bubble/structure interactions, which is of primary interest for the research activities of the Lab. Modelling efforts will be eventually assessed against experiments. More specifically, the project is composed of the following tasks:
1. Getting familiar with the numerical models and methods implemented in ECOGEN, and literature review about acoustic source models dedicated to ultrasound and HIFU. 2. Implement an acoustic source model in ECOGEN for simulating (high-intensity) unfocused, focused and diverging ultrasound beam operating over the kHz-MHz range. 3. Validate the modelling against experimental measurements available in the literature and data from the Lab. 4. Run experimental test case(s) to assess the performance of numerical model for simulating HIFU/bubble(s) interactions. 5. Documentation and presentation of the project results and acoustic source model