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Blood-retinal-barrier (BRB) organ-on-a-chip
We are seeking a Master's thesis student for a collaborative project between Roche in Basel and the Macromolecular Engineering Laboratory at ETH Zürich to improve the design of organ-on-a-chip models of the blood-retinal-barrier for improved drug screening and discovery.
The Neuroscience, Ophthalmology and Rare Diseases (NORD) Translational Area (DTA) of Roche Pharmaceutical Research & Early Development (pRED) has opening for a Master thesis within the Ophthalmology Discovery department located in Basel, Switzerland. This group of over 30 Roche scientists is focused on the clinical translation of therapeutic approaches for eye diseases, including age related macular degeneration, diabetic retinopathy, and glaucoma.
The student will work in Basel at the Roche laboratories as part of the Ophthalmology team, gaining significant exposure to drug development, biomarker discovery, and clinical translation and at the Macromolecular Engineering Laboratory in the department of Mechanical Engineering at ETH, which has expertise in polymer physics and tissue engineering. While a collaboration between the two institutions, most of the research will occur at Roche in Basel.
The goal of this basic research project is to develop a mechanistic understanding on how matrix properties influence cell behavior in the context of a blood-retinal-barrier (BRB) organ-on-a-chip model. The student will investigate the effect of matrix stiffness and composition on endothelial cells and barrier integrity and will use this knowledge to implement the design of organ-on-chip systems of the BRB currently under development at Roche. This project involves: characterization of endothelial cells on different matrices, fabrication of matrices with defined properties, and integration of matrices in organ-on-a-chip devices.
We are seeking an exceptional and highly motivated student with background in biomaterials science, tissue engineering, cell biology, or related fields. Strong written and oral communication skills in English are required.
The Neuroscience, Ophthalmology and Rare Diseases (NORD) Translational Area (DTA) of Roche Pharmaceutical Research & Early Development (pRED) has opening for a Master thesis within the Ophthalmology Discovery department located in Basel, Switzerland. This group of over 30 Roche scientists is focused on the clinical translation of therapeutic approaches for eye diseases, including age related macular degeneration, diabetic retinopathy, and glaucoma.
The student will work in Basel at the Roche laboratories as part of the Ophthalmology team, gaining significant exposure to drug development, biomarker discovery, and clinical translation and at the Macromolecular Engineering Laboratory in the department of Mechanical Engineering at ETH, which has expertise in polymer physics and tissue engineering. While a collaboration between the two institutions, most of the research will occur at Roche in Basel.
The goal of this basic research project is to develop a mechanistic understanding on how matrix properties influence cell behavior in the context of a blood-retinal-barrier (BRB) organ-on-a-chip model. The student will investigate the effect of matrix stiffness and composition on endothelial cells and barrier integrity and will use this knowledge to implement the design of organ-on-chip systems of the BRB currently under development at Roche. This project involves: characterization of endothelial cells on different matrices, fabrication of matrices with defined properties, and integration of matrices in organ-on-a-chip devices.
We are seeking an exceptional and highly motivated student with background in biomaterials science, tissue engineering, cell biology, or related fields. Strong written and oral communication skills in English are required.
Integrate engineered hydrogels as extracellular mimics within microengineered organ-on-a-chip models of the BRB. Improve workflow and throughput of BRB organ-on-a-chip models.
Integrate engineered hydrogels as extracellular mimics within microengineered organ-on-a-chip models of the BRB. Improve workflow and throughput of BRB organ-on-a-chip models.
Prof. Dr. Mark W. Tibbitt (ETH) - mtibbitt@ethz.ch
Dr. Héloïse Ragelle (Roche) - heloise.ragelle@roche.com
Prof. Dr. Mark W. Tibbitt (ETH) - mtibbitt@ethz.ch Dr. Héloïse Ragelle (Roche) - heloise.ragelle@roche.com
Master thesis Roche_ETH_v2.pdf
