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Impact of diesel exhaust pollution particles on placental signaling as an indicator for potential embryo-fetal risks
Exposure to air pollution during pregnancy can result in adverse effects on fetal development and health later in life. In particular, prenatal exposure to traffic related diesel exhaust particles (DEPs) is as-sociated with a number of embryo-fetal disorders and adverse health effects in later life,
You can expect significant support and guidance from established scientists. In this project, you can ob-tain a broad set of lab skills including primary tissue isolation and culture, (advanced) imaging tech-niques, nanoparticle characterization and different analytical methods.
Earliest start: 01.02.2021
Latest end: approx. 6 months from start of project
Location: Empa, St. Gallen, Switzerland
You can expect significant support and guidance from established scientists. In this project, you can ob-tain a broad set of lab skills including primary tissue isolation and culture, (advanced) imaging tech-niques, nanoparticle characterization and different analytical methods.
Earliest start: 01.02.2021 Latest end: approx. 6 months from start of project Location: Empa, St. Gallen, Switzerland
The aim of this master thesis project is to investigate the impact of DEPs on placental tissue explants from early and late pregnancy.
• Investigate viability and functionality as well as secretion profile of human placental explants upon DEPs exposure
• Collect conditioned tissue culture medium and study impact of (particle-induced) released pla-cental mediators on angiogenic and neurodevelopmental processes in vitro
• Analyze selected placental mediators in perfusates collected from ex vivo perfused placentas and compare to secreted factors in the explant models.
The aim of this master thesis project is to investigate the impact of DEPs on placental tissue explants from early and late pregnancy. • Investigate viability and functionality as well as secretion profile of human placental explants upon DEPs exposure • Collect conditioned tissue culture medium and study impact of (particle-induced) released pla-cental mediators on angiogenic and neurodevelopmental processes in vitro • Analyze selected placental mediators in perfusates collected from ex vivo perfused placentas and compare to secreted factors in the explant models.
Interested students should send a CV and motivation statement to:
Battuja Batbajar Dugershaw, Empa-Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5 CH - 9014 St. Gallen, Switzerland https://www.empa.ch/web/s403/particlesbarrier
battuja.batbajar@empa.ch; Tel +41 58 765 7640
Interested students should send a CV and motivation statement to: Battuja Batbajar Dugershaw, Empa-Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5 CH - 9014 St. Gallen, Switzerland https://www.empa.ch/web/s403/particlesbarrier battuja.batbajar@empa.ch; Tel +41 58 765 7640