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Development medical adhesives for cartilage tissue
For the successful integration of an engineered cartilage tissue graft, the graft should be stably attached on the damaged tissue site. In this project, we aim at developing pressure-inducible tissue adhesives for cartilage damage repair.
Keywords: cartilage, tissue regeneration, medical adhesive, nanoparticle
Grafting an engineered cartilage tissue onto the damaged tissue site is one of the promising approaches for cartilage tissue repair. During the process, long-term, stable attachment of the tissue graft is very important for successful healing of cartilage tissues. In this project, we aim to develop cartilage tissue-specific medical adhesives using nanoparticle dispersion. According to recent discovery, nanoparticle dispersion can effectively glue two gels or tissues together. Unlike polymer-based medical adhesives, the nanoparticle-based adhesion does not involve chemical crosslinking but physical adsorption of polymers to nanoparticle surfaces. This physical adsorption can be induced by mechanical press and can be reversed, which facilitates self-healing adhesion of an engineered tissue in high load-bearing tissue environments. To achieve this, the surface of nanoparticles would be modified with molecules that can bind to both native and engineered cartilage tissue. An engineered tissue, i.e. hydrogel, would be prepared. Adhesion strength and cytotoxicity of the prepared adhesives would be assessed using bovine cartilage and chondrocytes.
Grafting an engineered cartilage tissue onto the damaged tissue site is one of the promising approaches for cartilage tissue repair. During the process, long-term, stable attachment of the tissue graft is very important for successful healing of cartilage tissues. In this project, we aim to develop cartilage tissue-specific medical adhesives using nanoparticle dispersion. According to recent discovery, nanoparticle dispersion can effectively glue two gels or tissues together. Unlike polymer-based medical adhesives, the nanoparticle-based adhesion does not involve chemical crosslinking but physical adsorption of polymers to nanoparticle surfaces. This physical adsorption can be induced by mechanical press and can be reversed, which facilitates self-healing adhesion of an engineered tissue in high load-bearing tissue environments. To achieve this, the surface of nanoparticles would be modified with molecules that can bind to both native and engineered cartilage tissue. An engineered tissue, i.e. hydrogel, would be prepared. Adhesion strength and cytotoxicity of the prepared adhesives would be assessed using bovine cartilage and chondrocytes.
The aim of this project is to develop cartilage tissue-specific medical adhesives by nanoparticle dispersion for successful tissue integration and regeneration.
The aim of this project is to develop cartilage tissue-specific medical adhesives by nanoparticle dispersion for successful tissue integration and regeneration.