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PhD position in University of Zurich, Switzerland
This PhD project aims to develop technologies to overcome the gap between on-chip and rodent pharmacokinetics and improve in vitro to in vivo extrapolation. We will use an integrated deep learning approach to recapitulate pharmacokinetics from hybrid dynamic imaging of rodent-on-chip.
Job description
Pharmacokinetics is a critical factor for toxicity of new pharmaceuticals. This PhD project aims to develop technologies to overcome the gap between on-chip and rodent pharmacokinetics and improve in vitro to in vivo extrapolation. We will use an integrated deep learning approach to recapitulate pharmacokinetics from hybrid dynamic imaging of rodent-on-chip. The student will develop a novel technology combining optoacoustic and positron imaging to measure the dynamic course of pharmaceutical uptake for rodent-on-chip, develop whole-body pharmacokinetic measurements of and rodents to support the development of intelligent extrapolation. The student will have the opportunity to learn state-of-the art PET imaging, optoacoustic imaging and organ-on-a-chip approaches.
Your qualifications
We are looking for students with the following qualifications:
• Master degree in life science, Pharmacology or Biomedical Engineering
• Strong interest in cell, neuroscience, Pharmacology and biomedical imaging;
• Fluency in English (oral and written);
• Previous research experience in biomedical imaging (PET, Photoacoustic), organoid and cell biology (desirable);
• Programming skill, MATLAB, python (desirable)
We offer a nice working place in a multi-discipline, dynamic academic environment with close collaboration with hospitals. The student will be enrolled in the ZNZ programme. The ZNZ doctoral program, founded in 1998, offers students of different disciplines a solid foundation in the neurosciences. With over 600 alumni and an average of 300 registered students, it is the largest PhD program in the Life Science Zurich Graduate School.
Your application
Highly motivated applicants may send their application and include a letter of motivation, CV and 2 reference letters to Dr. Ruiqing Ni ruiqing.ni@uzh.ch. University of Zurich encourages applications from female applicants.
Deadline : 30.06.2020
Job description Pharmacokinetics is a critical factor for toxicity of new pharmaceuticals. This PhD project aims to develop technologies to overcome the gap between on-chip and rodent pharmacokinetics and improve in vitro to in vivo extrapolation. We will use an integrated deep learning approach to recapitulate pharmacokinetics from hybrid dynamic imaging of rodent-on-chip. The student will develop a novel technology combining optoacoustic and positron imaging to measure the dynamic course of pharmaceutical uptake for rodent-on-chip, develop whole-body pharmacokinetic measurements of and rodents to support the development of intelligent extrapolation. The student will have the opportunity to learn state-of-the art PET imaging, optoacoustic imaging and organ-on-a-chip approaches.
Your qualifications We are looking for students with the following qualifications: • Master degree in life science, Pharmacology or Biomedical Engineering • Strong interest in cell, neuroscience, Pharmacology and biomedical imaging; • Fluency in English (oral and written); • Previous research experience in biomedical imaging (PET, Photoacoustic), organoid and cell biology (desirable); • Programming skill, MATLAB, python (desirable) We offer a nice working place in a multi-discipline, dynamic academic environment with close collaboration with hospitals. The student will be enrolled in the ZNZ programme. The ZNZ doctoral program, founded in 1998, offers students of different disciplines a solid foundation in the neurosciences. With over 600 alumni and an average of 300 registered students, it is the largest PhD program in the Life Science Zurich Graduate School. Your application Highly motivated applicants may send their application and include a letter of motivation, CV and 2 reference letters to Dr. Ruiqing Ni ruiqing.ni@uzh.ch. University of Zurich encourages applications from female applicants. Deadline : 30.06.2020