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Postdoc project: Synergistic effects between immune peptides
This project unravels the mystery of the mechanism of AMP synergistic effects, where different types of AMPs assemble into hybrid peptides for presenting a desired function.
Antimicrobial peptides (AMP) are small molecules (< 10 kDa) that our body produces right after it is infected by pathogens such as viruses and bacteria. They are the common weapons against different types of pathogens as the first line of defense (innate immunity). There are tens of kinds of AMPs in our bodies and their expression level is different in each organ. The current center of debate is why there are so many different kinds of AMPs and how that is linked to their diverse functions? Recently, synergistic effects between 2 types of AMPs have been reported, where bacteria die only when 2 types of AMPs are mixed. However, its mechanism is unknown.
In this project, we will unravel the mystery of the mechanism of AMP synergistic effects, where different types of AMPs assemble into hybrid peptides for presenting a desired function.
Antimicrobial peptides (AMP) are small molecules (< 10 kDa) that our body produces right after it is infected by pathogens such as viruses and bacteria. They are the common weapons against different types of pathogens as the first line of defense (innate immunity). There are tens of kinds of AMPs in our bodies and their expression level is different in each organ. The current center of debate is why there are so many different kinds of AMPs and how that is linked to their diverse functions? Recently, synergistic effects between 2 types of AMPs have been reported, where bacteria die only when 2 types of AMPs are mixed. However, its mechanism is unknown.
In this project, we will unravel the mystery of the mechanism of AMP synergistic effects, where different types of AMPs assemble into hybrid peptides for presenting a desired function.
To understand the mechanism of AMP synergistic effects, we study the interaction between AMP mixtures and cell membranes by methods in physical chemistry; electrochemical impedance spectroscopy (EIS), single channel measurements, fluorescence spectroscopy, circular dichroism (CD), quartz crystal microbalance (QCM), atomic force microscopy (AFM) etc.
To understand the mechanism of AMP synergistic effects, we study the interaction between AMP mixtures and cell membranes by methods in physical chemistry; electrochemical impedance spectroscopy (EIS), single channel measurements, fluorescence spectroscopy, circular dichroism (CD), quartz crystal microbalance (QCM), atomic force microscopy (AFM) etc.
The project is for a postdoc. For general information, please visit our website http://www.unige.ch/sciences/chifi/sugiharalab/. If you would like to apply, please send an application including (1) Motivation letter, (2) Your complete CV, (3) Full contact information of two professional references with phone and email. The entire application material should be sent as a single email to kaori.sugihara@unige.ch.
The project is for a postdoc. For general information, please visit our website http://www.unige.ch/sciences/chifi/sugiharalab/. If you would like to apply, please send an application including (1) Motivation letter, (2) Your complete CV, (3) Full contact information of two professional references with phone and email. The entire application material should be sent as a single email to kaori.sugihara@unige.ch.