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Investigation of cerebrovascular alterations in aging mouse models by multimodal imaging
Aging is a major risk factor for many neurodegenerative and metabolic diseases. Student will investigate the cerebrovascular, heamodynamic and pathphyiological alternations in brain of aging mouse model, by using high-resolution functional MRI, photoacoustic tomography and confocal microscopy.
Aging is a major risk factor for many neurodegenerative and metabolic diseases such as Alzheimer’s disease and type II diabetes. The advances in neuroimaging such as high resolution functional magnetic resonance imaging (MRI) provide valuable tools for understanding dynamics and pathophysiology in the living brain. Novel photoacoustic tomography provides 3D in vivo visualization of deep-tissue targets with intrinsic contrasts or optically active probes. The aims of this study are to 1) investigate the age-related alterations in cerebral vasculature, cerebral blood flow and cerebral vascular reactivity by in vivo MRI and hemodynamics by photoacoustic tomography; morphology of vasculature by ex vivo immunochemical staining and confocal microscopy; 2) establish novel dynamic contrast enhanced photoacoustic tomography by using gold nanoparticle as contrast agent.
This master thesis aims to investigate the cerebrovascular and pathological alternations in Alzheimer transgenic mouse and wild-type mouse using high-resolution MRI. The experiments includes MRI analysis for cerebral bleed flow, cerebrovascular reactivity, oxygen metabolism in vivo in mouse brain, ex vivo confocal microscopy. The project consists 40% experiment, 30% analysis, 10% reading 20% report/thesis writing. Seminars in the group and organized by institute of Biomedical engineering every week provide state-of art imaging acquisition and analysis methods.
Aging is a major risk factor for many neurodegenerative and metabolic diseases such as Alzheimer’s disease and type II diabetes. The advances in neuroimaging such as high resolution functional magnetic resonance imaging (MRI) provide valuable tools for understanding dynamics and pathophysiology in the living brain. Novel photoacoustic tomography provides 3D in vivo visualization of deep-tissue targets with intrinsic contrasts or optically active probes. The aims of this study are to 1) investigate the age-related alterations in cerebral vasculature, cerebral blood flow and cerebral vascular reactivity by in vivo MRI and hemodynamics by photoacoustic tomography; morphology of vasculature by ex vivo immunochemical staining and confocal microscopy; 2) establish novel dynamic contrast enhanced photoacoustic tomography by using gold nanoparticle as contrast agent.
This master thesis aims to investigate the cerebrovascular and pathological alternations in Alzheimer transgenic mouse and wild-type mouse using high-resolution MRI. The experiments includes MRI analysis for cerebral bleed flow, cerebrovascular reactivity, oxygen metabolism in vivo in mouse brain, ex vivo confocal microscopy. The project consists 40% experiment, 30% analysis, 10% reading 20% report/thesis writing. Seminars in the group and organized by institute of Biomedical engineering every week provide state-of art imaging acquisition and analysis methods.
to understand the age-related alterations in cerebrovascular function, metabolism using multimodal imaging
to understand the age-related alterations in cerebrovascular function, metabolism using multimodal imaging
Dr. Ruiqing Ni, ni@biomed.ee.ethz.ch
Prof. Jan Klohs, klohs@biomed.ee.ethz.ch
Institute of Biomedical Engineering
ETH Zurich & University of Zurich
HIT E 22.4 Wolfgang-Pauli-Str. 27
8093 Zurich
Dr. Ruiqing Ni, ni@biomed.ee.ethz.ch Prof. Jan Klohs, klohs@biomed.ee.ethz.ch
Institute of Biomedical Engineering ETH Zurich & University of Zurich HIT E 22.4 Wolfgang-Pauli-Str. 27 8093 Zurich
Each year the IDEA League offers the students of its partner universities over 180 monthly grants for a short-term research exchange. In general, these grants are awarded based on academic merit. For more information visit http://idealeague.org/student-grant/