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Drug delivery polymers for ingestible medication forms
Here you will join the effort to develop an ingestible drug delivery system that allows for controlled release of drug to treat Malaria, HIV and TC. Chemical synthesis and in vivo work will enable a successful vehicle design that is safe, effective and a platform for a variety of small molecule drug
Keywords: drug delivery, polymer chemistry, conjugation chemistry, medical devices
The treatment of infectious diseases such as Malaria, HIV and Tuberculosis fails in 50-80% of the cases globally due to patient’s non-adherence to a medication plan, which typically requires the intake of multiple pills per day. The reasons are complex, and the results are antibacterial resistances and generally heavy public health and economical burden. What if such diseases could be treated “fail-safe” with only one single ingestion? The Langer and Traverso Laboratories work at the interface of Chemical, Mechanical, Biomedical Engineering and Clinical Medicine to design novel approaches of polymeric, orally administered, gastro-retentive drug delivery devices. These are designed to reside in the gastrointestinal (GI) tract for several weeks without loss of function or negative side-effects, while releasing a drug in a controlled fashion. The success of such devices would radically change the way medical treatment is performed, and have a real-life impact on developing as well as developed countries.
The treatment of infectious diseases such as Malaria, HIV and Tuberculosis fails in 50-80% of the cases globally due to patient’s non-adherence to a medication plan, which typically requires the intake of multiple pills per day. The reasons are complex, and the results are antibacterial resistances and generally heavy public health and economical burden. What if such diseases could be treated “fail-safe” with only one single ingestion? The Langer and Traverso Laboratories work at the interface of Chemical, Mechanical, Biomedical Engineering and Clinical Medicine to design novel approaches of polymeric, orally administered, gastro-retentive drug delivery devices. These are designed to reside in the gastrointestinal (GI) tract for several weeks without loss of function or negative side-effects, while releasing a drug in a controlled fashion. The success of such devices would radically change the way medical treatment is performed, and have a real-life impact on developing as well as developed countries.
Develop polymer architectures and chemical pathways to achieve the goals for this drug delivery device: ingestibility, large drug load, controlled release from the matrix, safe passage.
Develop polymer architectures and chemical pathways to achieve the goals for this drug delivery device: ingestibility, large drug load, controlled release from the matrix, safe passage.