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Development of microfluidic technology for microvascular disease
In this project, microfluidics is leveraged for the study in-vitro of (coronary) microvascular disease. Biocompatible materials are used to microfabricate the platforms used for cytocompatibility and hemorheological assays.
Microvasculature is subjected to a plethora of diseases that are poorly understood and diagnosed. The systematic integration of microfluidics in the analysis of coronary microvascular disease is essential for a better understanding of the hemodynamic alteration and the consequent endothelial dysfunction leading to the pathological cardiac impairment. Starting from the latest experimental set-up and chips microfabricated in our group, we herein propose to optimize the microvascular perfusion model through in-silico and/or in-vitro modelling, with the final goal of replicating with high-fidelity the pathological condition observed in-vivo through qualitative positron emission tomography images.
To achieve this goal, we will need to:
- Optimize the **perfusing** system for a controlled hemodynamic stimulation;
- Characterize the biomechanical and **biocompatibility** properties of the developed platform for endothelial cell seeding.
Microvasculature is subjected to a plethora of diseases that are poorly understood and diagnosed. The systematic integration of microfluidics in the analysis of coronary microvascular disease is essential for a better understanding of the hemodynamic alteration and the consequent endothelial dysfunction leading to the pathological cardiac impairment. Starting from the latest experimental set-up and chips microfabricated in our group, we herein propose to optimize the microvascular perfusion model through in-silico and/or in-vitro modelling, with the final goal of replicating with high-fidelity the pathological condition observed in-vivo through qualitative positron emission tomography images. To achieve this goal, we will need to: - Optimize the **perfusing** system for a controlled hemodynamic stimulation; - Characterize the biomechanical and **biocompatibility** properties of the developed platform for endothelial cell seeding.
Not specified
Dr. Monika Colombo, monika.colombo@chem.ethz.ch
deMello group, Institute for Chemical and Bioengineering, D-CHAB
Dr. Monika Colombo, monika.colombo@chem.ethz.ch
deMello group, Institute for Chemical and Bioengineering, D-CHAB