Translational Molecular PsychiatryOpen OpportunitiesWe are seeking a highly motivated Master student (for a master thesis lasting 6-12 months) who is interested in conducting research on disease modeling using cells from attention-deficit hyperactivity disorder (ADHD) patients. The approach includes acquiring proficiency in handling human induced pluripotent stem cells (iPSCs), neural stem cells (NSCs), and mature neuronal culture. The aim of the present work is to clarify the impact of methylphenidate on the release of dopamine and the alterations in the dopamine transporter availability, in conjunction with the sigma-1 receptor, in ADHD lines, as compared to controls. This may elucidate the discrepancies in response to methylphenidate between individuals with ADHD and those without the condition. - Cell Neurochemistry, Cellular Nervous System, Central Nervous System, Pharmacology and Pharmaceutical Sciences
- Master Thesis
| Our lab is looking for a highly motivated Master student (6-12 months), who is interested to conduct a research in the field of disease modeling using ADHD patient-specific cells. The process will involve learning how to analyze preexisting data from single cell RNA sequencing (scRNAseq) generated from neural stem cells (NSCs) and forebrain cortical neurons (FCNs) derived from human induced pluripotent stem cells (iPSCs), by using bioinformatics. These cell lines were previously generated in our lab and are derived from patients with Attention-Deficit Hyperactivity Disorder (ADHD). We will investigate the transcriptome profile of both NSCs and FCNs, which will include analyzing the Wnt signaling pathway. This pathway plays a crucial role in coordinating important cellular events during neurodevelopment. Moreover, the student will learn how to scientifically interpret and discuss scientific papers and conduct research with independence and critical thinking. - Cell Development (incl. Cell Division and Apoptosis), Computational Biology and Bioinformatics, Neurosciences, Psychiatry, Quantitative Genetics
- Master Thesis
| Our lab is looking for a highly motivated Master student (6-12 months), who is interested to conduct a research in the field of disease modeling using ADHD patient-specific cells. The process will involve learning how to generate and culture human induced pluripotent stem cells (iPSCs) and generation of neural stem cells (NSCs) from patients with Attention-Deficit Hyperactivity Disorder (ADHD), as well as how to scientifically interpret and discuss scientific papers and conduct research with independence and critical thinking. - Biochemistry and Cell Biology, Neurosciences, Pharmacology and Pharmaceutical Sciences
- Master Thesis
| Our lab is looking for a highly motivated Master student (6-12 months), who is interested to conduct a research in the field of disease modeling using ADHD patient-specific cells. The process will involve learning how to generate and culture human induced pluripotent stem cells (iPSCs) and generation of Neural Stem Cells (NSCs) and Forebrain Cortical Neurons (FCNs) from patients with Attention-Deficit Hyperactivity Disorder (ADHD), as well as how to scientifically interpret and discuss scientific papers and conduct research with independence and critical thinking. - Biochemistry and Cell Biology, Neurosciences, Pharmacology and Pharmaceutical Sciences
- Master Thesis
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