Paraplegiology / Spinal Cord Injury CenterOpen OpportunitiesMigraine can be observed more often in patients with epilepsy. Both diseases are
probably network diseases. However, for both diseases cortical as well as non-cortical (e.g. brainstem and spinal cord) regions have been insufficiently investigated anatomically and functionally using modern high-field MR imaging. The goal of this project is to provide the first detailed in vivo and mechanistic quantification of functional and microstructural network changes with clinically certified high-field MRI (7 Tesla) in patients with DRE and migraine. - Central Nervous System, Neurology and Neuromuscular Diseases, Radiology and Organ Imaging
- Master Thesis
| The main tract for transmitting noxious stimuli is the spinothalamic tract, receiving its input from different types of small fibers in the skin i.e., mechanical- or heat-sensitive fibers. In spinal cord injury as in other pathologies involving neuropathic pain and sensation deficits, it is crucial to assess spinothalamic tract integrity with objective methods. This depends on a well-characterized stimulation modality, activating small fibers, and implies the recording of brain activity in response to this stimulation (electroencephalography; EEG). Intra-epidermal electrical stimulation (IES) using a concentric triple electrode is known for its clinical potential due to small fiber activation and is a good candidate for the activation of the spinothalamic tract. However, to implement IES as a diagnostic tool in the clinical routine, feasibility, and test-retest reliability need to be assessed compared to other stimulation modalities. - Central Nervous System, Neurology and Neuromuscular Diseases, Peripheral Nervous System, Sensory Systems
- Bachelor Thesis, Internship, Master Thesis, Semester Project
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