Bio Engineering LaboratoryOpen OpportunitiesElectrophysiological recording systems, such as patch-clamp rigs and in-vitro neural interfaces, are designed to capture minute voltage signals (<100 µV) produced by electrogenic cells. These systems often comprise multiple instruments that face electromagnetic compatibility challenges, including ground loops and conflicting electric and magnetic fields. This project seeks to investigate the underlying causes of these issues and develop solutions to enhance the reliability and robustness of electrophysiological recordings. - Biosensor Technologies, Electrical Engineering, Engineering/Technology Instrumentation
- Master Thesis, Semester Project
| The focus of this project is on the fabrication of microelectrodes for advanced neural interfaces in a cutting-edge cleanroom environment. Our research aims to develop high-resolution neural probes utilizing state-of-the-art microfabrication techniques. - Biomedical Engineering, Biosensor Technologies, Mechanical Engineering, Nanotechnology
- Master Thesis, Semester Project
| This project focuses on the design of low-noise, low-power, compact amplifiers for next-generation neural interfaces. - Integrated Circuits
- Master Thesis, Semester Project
| During development cells must assume different fates in a position-dependent manner. Morphogen gradients are able to encode this positional information, in order to guide tissue patterning during embryonic development. In the French flag model of patterning, morphogen concentration levels determine tissue domains of different cell fates. However, current in vitro 3D cell models fail to reproduce the patterning observed in vivo. Our aim is to generate 3D cell models which are able to reproduce patterning, thus allowing us to study morphogen gradients in diverse stages of development. - Cell Development (incl. Cell Division and Apoptosis)
- Master Thesis, Semester Project
| The student will culture neurons on a microelectrode array, and will record the electrical activity of the network and follow its evolution over time. The development of new methods for signal processing, neuron stimulation, and imaging can be included in the project depending on the experience and interests of the student. - Biology, Biomedical Engineering, Engineering/Technology Instrumentation, Neurosciences
- Bachelor Thesis, Course Project, Lab Practice, Master Thesis, Semester Project
| The student will develop an FPGA-based platform for interacting with in-vitro neuronal cultures, including real-time spike detection and neuron stimulation. The project is focused on VHDL programming, although it could include other software development and/or wet-lab tasks with neurons depending on the interests of the student. - Electrical and Electronic Engineering, Neurosciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| This project is about the development of integrated circuits to study neurons and neural networks, and may comprise different parts of the design including analog and/or digital microelectronics, PCB design, signal processing and programming. - Electrical and Electronic Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| The student will be involved in the development of software applications for in-vitro neural interfaces. The ultimate goal is controlling a complex embedded system, comprising a custom-made CMOS neural interface and two system on a chip. - Electrical Engineering, Engineering/Technology Instrumentation, Mathematical Software, Programming Languages, Programming Techniques, Software Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| The Bio Engineering Lab (ETH Zurich, based in Basel) has a long tradition of pioneering densely-integrated CMOS devices capable of electrically interfacing with an in vitro neuronal systems (e.g. cultures, brain slices etc.). This position invites you to work on the fabrication methods and/or characterization of novel 3D structures that promote a strong coupling between the two heterogeneous systems, namely CMOS sensor chips and in vitro neurons. - Biomedical Engineering, Electrical and Electronic Engineering
- Master Thesis, Semester Project
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