Institute for Biomedical EngineeringOpen OpportunitiesScanning ion conductance microscopy (SICM) is the non-contact SPM technology to image live cells based on glass capillaries with a nanometric aperture. It applies a voltage and measures the ionic current flowing through the pipette above the sample in the buffer solution: the recorded current represents the feedback signal to measure the topography of the sample. In collaboration with Prof. Fantner at EPFL, this project aims to assemble a state of the art high-speed SICM to enable time-resolved live cell imaging. - Biomedical Engineering, Electrical and Electronic Engineering, Mechanical Engineering, Nanotechnology, Signal Processing
- Bachelor Thesis, Course Project, ETH Zurich (ETHZ), Lab Practice, Master Thesis, Summer School
| What about implantable self-powering devices to monitor biophysical signals at nanoscale? As a part of the interdisciplinary frontier between material science and new biomedical applications, being able to monitor biological or physical markers and signals, allows for a better treatment from both the diagnostic and healing point of view. Among them, biocompatible and non-intrusive wearable monitoring devices, which are so flexible to adhere perfectly to biological tissue, and even to cells like neurons, gain increasing interest. However, fabricating the devices and the electrodes at nano/microscale remains a challenge.
FluidFM is a force-controlled nanopipette, a versatile tool also for 2D patterning and 3D printing in liquid environment, opening the opportunity to manufacture the devices at the sub-micron scale.
We are going to create the devices and electrodes depositing conductive polymers with the FluidFM and then to perform the opportune electrical characterization. - Electrical and Electronic Engineering, Materials Engineering, Medical and Health Sciences, Physics
- Master Thesis
| The aim of the project is to investigate the benefits, requirements and drawbacks of physics informed neural networks in the context of personalised cardiac and cardiovascular models - Biomechanical Engineering, Clinical Engineering, Computation Theory and Mathematics, Fluidization and Fluid Mechanics, Neural Networks, Genetic Alogrithms and Fuzzy Logic, Simulation and Modelling
- Master Thesis
| Pemphigus vulgaris (PV) is a unique group of autoimmune diseases. Researches have demonstrated that antibody-induced disruption of Dsg3 transadhesion initiates a signaling response in basal keratinocytes followed by loss of tissue integrity. The complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space.
To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cell topography and bioelectricity) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
Together with the University of Bern and University of Lübeck, we aim to utilize the tools to study the topography and electrophysiology (cell potential, ion channel recording, localized ion detection, charges) of HPEK cells (human primary keratinocytes cells) to unravel the signaling pathways of the disease. We utilize optical imaging (fluorescence dyes) and biosensing tools (including the state of the art hs-SICM and electrical FluidFM setup) to study HPEK cells upon desmosome disruption.
- Biology, Biomedical Engineering, Chemistry, Electrical and Electronic Engineering, Interdisciplinary Engineering, Medical and Health Sciences
- Bachelor Thesis, Lab Practice, Master Thesis, Semester Project, Summer School
| The project focuses exploiting generative AI to build synthetic numerical phantom for cardiac anatomy and function suitable for representing population variability. - Biomechanical Engineering, Information, Computing and Communication Sciences
- Master Thesis
| In this project, you will have the opportunity to contribute to the development and optimization of a single-molecule sensor designed for the detection, identification, and sequencing of important biomolecules such as DNA and proteins. The sensor technology is built upon the principles of microfluidics, nanofabrication, and machine-learning data analysis. It is an excellent fit for students who possess skills and a strong interest in these fields and are eager to engage in an interdisciplinary project with significant potential impact. - Biology, Chemistry, Engineering and Technology, Medical and Health Sciences, Physics
- Master Thesis
| The project aims to modernize and improve the process of medical image registration, currently performed through a method known as pTV. Offering a unique combination of numerical programming and practical software implementation, this project promises visibility and application in the ever-evolving field of medical imaging technology. Suitable as a semester-long or master's project. - Computer Software, Medical and Health Sciences
- Bachelor Thesis, Course Project, ETH Zurich (ETHZ), Lab Practice, Master Thesis, Semester Project
| The aim of this project is to develop a camera-based solution for motion correction of cerebrovascular 4D flow MRI, including hardware development and (deep learning-based) data analysis. - Biomedical Engineering, Computer Vision
- Bachelor Thesis, Master Thesis
| Take part in an cutting-edge project aimed at building a novel ultrasound transducer concept. Develop a prototype, model its ultrasound response and test it in our lab. - Mechanical Engineering, Medical Physics, Robotics and Mechatronics
- Master Thesis, Semester Project
| You will develop a diagnostic test for testicular cancer. The focus of the project will be on creating the biochemical protocols for the test. The project is in collaboration with a prelaunch startup and a hospital (USZ). Therefore, it is ideal for motivated students who want to have a direct impact - Analytical Biochemistry, Biological and Medical Chemistry, Biomedical Engineering, Immunological and Bioassay Methods, Interdisciplinary Engineering, Materials Engineering, Sensor (Chemical and Bio-) Technology
- Bachelor Thesis, Internship, Lab Practice, Master Thesis, Semester Project, Summer School
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