University of Zurich
Phosphate is an essential mineral that must be absorbed from diet, is redistributed between different organs, and is either excreted into urine or reabsorbed by kidneys. These processes require a set of dedicated phosphate transporters. While several classes of phosphate transporters are known that mediate the apical uptake of phosphate into epithelial cells, the molecular identity of the transporters needed to release phosphate basolaterally has remained elusive.
- Biology, Medical and Health Sciences
- PhD Placement
Phosphate and calcium are essential minerals and important constituents of the skeleton. Phosphate and calcium must be absorbed from diet, redistributed between different organs, and are either excreted into urine or reabsorbed by kidneys. These processes are controlled by transporters, hormones and metabolic factors and are important for bone health as well as for protection from uncontrolled mineralization (e.g. in the cardiovascular system or kidney stones). Aging is associated with changes in mineral metabolism, as well as with bone-remodeling, bone-loss an increased risk for renal and cardiovascular disease and death. However, the links between aging and all these processes are unclear.
- Medical and Health Sciences
- PhD Placement
The aim of this project is to strengthen pioneering efforts in MRI of tissues and tissue components with very short-lived resonance signals.
- Biomedical Engineering, Electrical and Electronic Engineering, Physics
- Master Thesis
In the Magnetic Resonance Technology and Methods group (head Prof. Klaas Prüssmann), we are looking for a Physicist or Engineer to be employed as a PhD student.
- Engineering and Technology, Physics
- PhD Placement
ZuriMED Technologies AG is an innovation-driven Medtech start-up spun off from the Laboratory for Orthopedic Biomechanics at ETH Zurich.
At ZuriMED, we look for a dynamic and highly motivated student to join our design and development team.
If you are interested in being part of a Medtech start-up and obtaining a first insight into the product development process, this is an excellent opportunity.
- Biomechanical Engineering, Medical and Health Sciences
We are looking phd student for multinational JPND-funded project
• 3-4 years PhD position, excellent ZNZ neuroscience programme
• Working in a world top research institution with international, multi-disciplinary, highly innovative colleagues, and state-of-the-art environment.
• Excellent training, career development and exchange opportunities in the framework of multinational JPND-funded project
- Biology, Engineering and Technology, Medical and Health Sciences
- PhD Placement
Are you looking for a chance to improve your coding skills AND get plenty of fresh air?
Sounds impossible? Not if you can get an internship at Voliro!
- Aerospace Engineering, Data Format, Information Systems, Programming Languages, Software Engineering
Epilepsy is characterized by seizures. Therapy aims for seizure freedom or seizure reduction. Since seizures are rare events, diagnostic tools analyze the time between seizures, the interictal period. Interictal Epileptiform Discharges (IED) are a traditional and sensitive marker for epileptogenic brain tissue, which are, however, not very specific. More recently, High Frequency Oscillations (HFO) were defined as a more specific marker, which is, however, hard to detect The combination of IED and HFO is thought to improve diagnostic accuracy.
In a recent publication that analyzed scalp EEG, the combined presence of IED and HFO enhanced the localization of epileptogenic brain tissue (Cai et al. , 2021). We have published data where intracranial EEG was recorded in patients that were candidates for epilepsy surgery (Fedele et al. , 2017).
In the proposed project, we analyze intracranial EEG that was recorded while patients were in deep sleep (Fedele et al. , 2017). We test whether the combined presence of IED and HFO improves the prediction accuracy of postoperative seizure freedom.
Baud MO, Kleen JK, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, Chang EF. Unsupervised Learning of Spatiotemporal Interictal Discharges in Focal Epilepsy. Neurosurgery. 2018;83:683-91. https://doi.org/10.1093/neuros/nyx480
Cai Z, Sohrabpour A, Jiang H, Ye S, Joseph B, Brinkmann BH, Worrell GA, He B. Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources. Proc Natl Acad Sci U S A. 2021;118. https://doi.org/10.1073/pnas.2011130118
Fedele T, Burnos S, Boran E, Krayenbühl N, Hilfiker P, Grunwald T, Sarnthein J. Resection of high frequency oscillations predicts seizure outcome in the individual patient. Scientific Reports. 2017;7:13836. https://doi.org/10.1038/s41598-017-13064-1
- Neurology and Neuromuscular Diseases
- Internship, Master Thesis, MD, Semester Project
FluidFM is a state-of-the-art technology that can be used to create cell structures and formations in lab-on-chip devices, as well as positioning cellular microstructures for experimental configurations or bioprinting (https://lbb.ethz.ch/the-group/post-doc/connolly--sinead-dr-.html). It comprises a hollow atomic force microscopy (AFM) cantilever within which a positive or a negative pressure can be generated and used to pick up and put down single cells. The technology can also be used to measure adhesion forces in cells, for injection into single cells and for the extraction of cellular contents from cells.
- Biochemistry and Cell Biology, Biomedical Engineering, Interdisciplinary Engineering, Mechanical and Industrial Engineering, Systems Biology and Networks
- Bachelor Thesis, Internship, Master Thesis, Semester Project
X-ray tomography group of Prof. Dr. Marco Stampanoni invites current Bachelor and Master students to do your thesis or semester project in our team.
- Instruments and Techniques, Medical Physics
- Bachelor Thesis, ETH Organization's Labels (ETHZ), Master Thesis