University of Zurich
The Department of Neuro-Urology at the Spinal Cord Injury Center, University of Zürich and Balgrist University Hospital in Zürich, Switzerland, is offering a PhD positions for a highly motivated and scientifically interested PhD candidate to conduct clinical research joining neuroimaging with neuro-urology in humans. This position is embedded in an interdisciplinary research environment team of health care professionals, neuroscientists, physicists, biologists, human movement scientists, pharmacologists, and engineers. You will be involved in a nation-wide randomized, sham-controlled, double-blind clinical trial investigating transcutaneous tibial nerve stimulation in patients with acute spinal cord injury to prevent neurogenic detrusor overactivity (http://p3.snf.ch/Project-179644, supported by the Swiss National Science Foundation (SNSF) and the Swiss Paraplegics Foundation (SPS).
- Medical and Health Sciences
- PhD Placement
We have developed an age-sensor that translates cellular age into measurable fluorescence. The aim of this project is to use this age-sensor to track how neural stem cells age over time when overexpressing toxic proteins.
- Biochemistry and Cell Biology, Genetics, Neurosciences
- Internship, Master Thesis
We are looking for a motivated bachelor level undergraduate who wishes to earn a bit of money by helping with routine lab maintenance tasks. This includes autoclaving, recycling, restocking, making bacterial plates and more.
- Central Nervous System
- Student Assistant / HiWi
The goal of this project is to implement and evaluate state-of-the-art 3D surface reconstruction methods using multi-modality sensor data.
- Computer Graphics, Computer Vision, Image Processing, Pattern Recognition, Signal Processing
- Master Thesis, Semester Project
The autonomic nervous system reacts to pain, for example by adapting the heart rate or increased sweat output at the hands. Such pain-autonomic responses have been shown to be increased in chronic pain patients with a sensitized nociceptive system (Scheuren et al., 2023). However, pain-autonomic responses can also be influenced be positive and negative expectations (Aslaksen et al., 2008; Rhudy et al., 2018). Therefore, we aim to disentangle the effects of expectations and sensitization on pain-autonomic responses. For this reason, we will conduct a study in healthy participants, using experimentally induced sensitization and a placebo paradigm.
- Autonomic Nervous System
- Internship, Master Thesis
Optoacoustic (OA, also known as photoacoustic) imaging has massively evolved since the early 2000s when the in vivo feasibility was first demonstrated. This new imaging modality combines the advantages of optics and ultrasound to provide high-resolution images of spectrally-distinctive absorbers deep into tissues. This can be exploited e.g. to visualize oxygenated and deoxygenated hemoglobin as well as lipids or other chromophores with high specificity. After more than 15 years of growing use in preclinical research, OA is now being considered as a clinical imaging modality, with initial clinical trials offering promising results. In this context, we are looking for a motivated master student that can have the opportunity to analyze clinical data acquired with a state-of-the art OA imaging system.
- Clinical Engineering
- Master Thesis
Our goal is to pattern different DNA-based recognition elements or aptamers, precisely inside hydrogels that can serve as 3D microenvironments for tissue engineering, disease modeling, and drug screening. By integrating aptamers into hydrogel networks, we will create an interactive environment where molecules are scavenged or released inside hydrogel scaffolds.
- Biomaterials, Biomechanical Engineering, Colloid and Surface Chemistry, Electroanalytical Chemistry, Materials Engineering, Medical and Health Sciences, Nanotechnology, Polymerisation Mechanisms, Sensor (Chemical and Bio-) Technology, Synthesis of Macromolecules
- ETH Zurich (ETHZ), Internship, Master Thesis
Take part in an cutting-edge project aimed at using soft-robotics methods to change the shape of a single ultrasound transducer to form an image. Develop a prototype, model its ultrasound response and test it in our labs.
- Mechanical Engineering, Medical Physics, Robotics and Mechatronics
- Master Thesis, Semester Project
Pemphigus vulgaris (PV) is a unique group of autoimmune diseases. Researches have demonstrated that antibody-induced disruption of Dsg3 transadhesion initiates a signaling response in basal keratinocytes followed by loss of tissue integrity. The complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space.
To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cell topography and bioelectricity) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
Together with the University of Bern and University of Lübeck, we aim to utilize the tools to study the topography and electrophysiology (cell potential, ion channel recording, localized ion detection, charges) of HPEK cells (human primary keratinocytes cells) to unravel the signaling pathways of the disease. We utilize optical imaging (fluorescence dyes) and biosensing tools (including the state of the art hs-SICM and electrical FluidFM setup) to study HPEK cells upon desmosome disruption.
- Biology, Biomedical Engineering, Chemistry, Electrical and Electronic Engineering, Interdisciplinary Engineering, Medical and Health Sciences
- Bachelor Thesis, Lab Practice, Master Thesis, Semester Project, Summer School
Our lab offers several master projects. Interested students can choose between projects associated with (1) Therapy and Biomarkers in Prostate Cancer (2) Investigating the DNA repair mechanism in prostate cancer. 3)investigating the role of extracellular vesicles in prostate cancer metastasis.