Fracture healing is a complex process that involves inflammation, angiogenesis, and bone remodeling. The remodelling process helps maintain bone density, repair micro-damage that occurs due to everyday activities, and adapt bones to the specific needs of an individual's body. Mechanical loading is a crucial factor in the regulation of fracture healing. The forces and strains experienced by the bone during everyday activities influence the cellular responses, callus formation, bone deposition, remodelling, and, ultimately, the successful recovery of the fractured bone. The mechanisms underlying spatial cell reorganization during loading, which contributes to fracture healing, remain unclear. The project aims to investigate and explore the fracture healing process of mice using spatial transcriptome changes in response to mechanical loading. By shedding light on this aspect, the project aims to contribute to the broader understanding of fracture healing and potentially pave the way for more effective treatment strategies in the future. - Biological Mathematics, Computational Biology and Bioinformatics, Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences, Physics
- Bachelor Thesis, Course Project, ETH for Development (ETH4D) (ETHZ), ETH Zurich (ETHZ), IDEA League Student Grant (IDL), Internship, Master Thesis, Semester Project
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This project aims to extend traditional NavMesh techniques for use in legged robots with discrete rotational symmetry, such as ANYmal. While NavMeshes are commonly used in gaming for path planning, their adoption in robotics is limited due to assumptions about agent shape and reliance on static, geometry-based maps. We propose an online approach that dynamically generates NavMeshes in real time from RGB-D camera data, enabling robots to adapt to their environments. Additionally, we plan to embed semantic information into the meshes, allowing robots to navigate more effectively by understanding both geometric and environmental contexts. Our system will be validated in simulated environments and on real robots, offering a robust framework for path planning, obstacle avoidance, and reinforcement learning applications. - Engineering and Technology, Information, Computing and Communication Sciences
- Master Thesis, Semester Project
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The goal of the project is to modify commercially available conductive yarns to improve their operational properties for potential employment in novel garment-embedded sensors for human motion detection. - Engineering and Technology, Medical and Health Sciences, Other Chemistry
- Semester Project
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Lab-on-a-chip (LoC) devices can be effectively utilized for manipulating the growth of single cells such as pollen tubes (PTs), the fastest growing single cells. Integrating the LoC devices with the cellular force microscope (CFM) allows for in-situ mechanical characterizations of PTs while investigating and manipulating their growth in a highly automated manner. The goal of this project is to develop LoC devices for single cell manipulation and integrate them with CFM for in-situ biomechanical characterizations. - Biomedical Engineering, Mechanical Engineering
- Bachelor Thesis, Master Thesis, Semester Project
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The aim of this project is to develop a numerical solver to approximate the behavior of cavitation bubble clouds. The solver should model the interactions between bubbles and accurately predict their oscillatory dynamics, as well as their translation within the cloud. - Engineering and Technology
- Semester Project
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The project aims at investigating the influence of osteoporosis and the effect of different pharmacological treatments and mechanical loading on osteocyte lacunar properties and void spaces in vertebral bone in 3D.
This can be achieved by registering high (1.2 µm) to low (10.5 µm) resolution microCT images and running morphological analyses. - Biomedical Engineering, Medical and Health Sciences
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
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This project aims to develop an automated pipeline to localise bone cells from histology slices. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Electrical and Electronic Engineering, Interdisciplinary Engineering, Mathematics, Mechanical and Industrial Engineering, Medical Biotechnology, Statistics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
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In this project we seek to reconstruct 3D Gaussian Splatting scenes and capture motion as it happens. - Computer Graphics, Computer Vision, Intelligent Robotics
- Master Thesis
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This project aims to create large scale 3D Gaussian Splatting scenes using online robotic data. - Computer Graphics, Computer Vision, Intelligent Robotics
- Master Thesis
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This project endeavors to explore the dynamic interplay among calcium ions, bone graft substitutes, and resident immune cells in both orthotopic and ectopic environments, employing advanced ratiometric imaging techniques. - Biomaterials, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
- Bachelor Thesis, Internship, Master Thesis, Semester Project
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