 ETH Competence Center for Materials and Processes (MaP)| Acronym | MaP | | Homepage | http://www.map.ethz.ch/ | | Country | Switzerland | | ZIP, City | 8093 Zürich | | Address | Leopold-Ruzicka-Weg 4 | | Phone | +41 44 633 37 53 | | Type | Academy | | Parent organization | ETH Zurich | | Current organization | ETH Competence Center for Materials and Processes (MaP) | | Members | |
Open OpportunitiesPolymer networks are made by cross-linking polymer chains at their ends by means of a chemical reaction. While the properties of used reactions are usually very well characterized for small molecules, little is known about how the presence of a polymer chain and its length affect this reaction. In this project, we aim to study this, mostly experimentally, but also including a theoretical approach. We propose to start with boronic ester chemistry, which has been already characterized in literature and in our lab. the reactants will be functionalized on linear PEG chains. We plan on studying both the thermodynamic and kinetic parameters. - Characterisation of Macromolecules, Physical Chemistry of Macromolecules, Thermodynamics and Statistical Physics
- Bachelor Thesis, Master Thesis, Semester Project
| Bone exhibits a remarkable ability to adapt its microstructure in response to mechanical and metabolic demands. This process involves a dynamic balance between bone-forming osteoblasts and bone-resorbing osteoclasts, with osteocytes playing a crucial role in signaling micro-mechanical cues. Disruptions in these mechanisms, as seen in conditions like postmenopausal osteoporosis, lead to decreased bone density and increased fracture risk. Sclerostin is pivotal in determining bone formation or resorption in response to mechanical stimuli and is targeted by FDA-approved osteoporosis medications. However, the drug's mechanism and its interaction with mechanical loading remain unclear. This project aims to investigate bone's response to sclerostin antibody treatment and uncover the cellular mechanisms governing bone adaptation using single-cell mechanomics cluster analysis. - Computational Biology and Bioinformatics, Engineering and Technology, Mathematical Sciences, Medical and Health Sciences, Physics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Organ perfusion is a method by which blood and other fluids are oxygenated and pumped through organs including livers, kidneys, lungs and hearts in order to provide the organ with oxygen and nutrients. Various organ perfusion technologies are already in clinical use to improve organ preservation or even treat organs prior to transplantation. Furthermore, ex-vivo perfusion offers the unique opportunity to study whole organs as an isolated system. As perfusion durations are extended up to two weeks, perfusion devices have to maintain good perfusate quality. In the human body, blood is filtered in kidneys which remove mostly water soluble waste products and excrete them in form of urine. This function can be simulated with a hemodialysis filter and dialysate for ex-vivo perfused organs. Here, a semi-permeable membrane separates blood from an aqueous solution called dialysate. Waste products and toxins then diffuse through the membrane into the dialysate which is pumped into a waste container. The rate at which dialysate is pumped into the dialysis filter determines how fast products are removed from blood. Unfortunately, hemodialysis does not only remove unwanted waste products but also medication such as anticoagulants and antibiotics. Therefore, we need a better model that allows for calculation of mass transfer between blood and dialysate. - Biology, Clinical Engineering
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Semester Project
| Be part of a product development project at a startup! - Composite Materials, Pulp and Paper
- ETH Zurich (ETHZ), Internship
| Fracture healing is a complex process that involves inflammation, angiogenesis, and bone remodeling. The remodelling process helps maintain bone density, repair micro-damage that occurs due to everyday activities, and adapt bones to the specific needs of an individual's body. Mechanical loading is a crucial factor in the regulation of fracture healing. The forces and strains experienced by the bone during everyday activities influence the cellular responses, callus formation, bone deposition, remodelling, and, ultimately, the successful recovery of the fractured bone. The mechanisms underlying spatial cell reorganization during loading, which contributes to fracture healing, remain unclear. The project aims to investigate and explore the fracture healing process of mice using spatial transcriptome changes in response to mechanical loading. By shedding light on this aspect, the project aims to contribute to the broader understanding of fracture healing and potentially pave the way for more effective treatment strategies in the future. - Biological Mathematics, Computational Biology and Bioinformatics, Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences, Physics
- Bachelor Thesis, Course Project, ETH for Development (ETH4D) (ETHZ), ETH Zurich (ETHZ), IDEA League Autumn School (IDL), IDEA League Student Grant (IDL), Internship, Master Thesis, Semester Project
| Gynecological cancers, including cervical, endometrial, and ovarian cancers, account for ~15% of cancer diagnoses in women worldwide. It is expected that the number of women suffering from these cancers will continue to rise over the next decade, and yet there is not a good way for monitoring for the development of these cancers. For example, ovarian cancer has a mortality rate of > 65% due to late-stage diagnoses leading to poor treatment outcomes. This project will focus on the design of an intrauterine device (IUD), like those commonly used for long-term birth control, that can be used for patient-based monitoring for gynecological cancer development through the controlled release of a hydrogel bound sensing elements. - Biomedical Engineering, Chemical Engineering, Materials Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| Bone is a metabolically active, rigid connective tissue that provides structural support, facilitates movement, and protects vital organs. Micro-computed tomography (micro-CT) is a widely employed imaging technology to gain deeper insights into bone structure and function. We have recently introduced the mi-CT image data repository, an open-access platform dedicated to biomedical images obtained from micro-CT scans within our research group (https://www.mi-ct.ethz.ch/). This repository aims to facilitate research by developing an efficient online image management system, making the data easily accessible. Achieving open access to these tools necessitates the creation of interfaces between the online platform and existing Python-based preprocessing software. - Artificial Intelligence and Signal and Image Processing, Biomechanical Engineering, Computational Biology and Bioinformatics, Medical and Health Sciences, Programming Languages, Software Engineering
- Bachelor Thesis, Course Project, ETH for Development (ETH4D) (ETHZ), IDEA League Autumn School (IDL), IDEA League Student Grant (IDL), Internship, Master Thesis, Semester Project
| This project aims to develop a pipeline to register 2D histological images to 3D micro-CT images. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Interdisciplinary Engineering, Materials Engineering, Mathematical Sciences, Mathematical Software, Mechanical and Industrial Engineering, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| We seek a highly motivated Bachelor's or Master's student dedicated to developing and applying a mathematical model, simulation, optimization, and process control to deepen the scale-up of bone organoids. This project offers an opportunity to gain valuable work experience within a highly interdisciplinary and international team. - Differential, Difference and Integral Equations, Dynamical Systems, Modeling and Simulation, Optimisation, Process Control and Simulation, Stochastic Analysis and Modelling, Systems Biology and Networks, Systems Theory and Control
- Bachelor Thesis, IDEA League Student Grant (IDL), Internship, Master Thesis, Semester Project
| Current tissue engineering strategies fail to recreate the complex bone architecture where a 3D bone cell network resides in the cavities for mechano-regulation of bone remodeling. This project aims to create a 3D printed in vitro model of bone for medicine. - Biochemistry and Cell Biology, Biomaterials, Interdisciplinary Engineering, Macromolecular Chemistry, Mechanical and Industrial Engineering, Medical and Health Sciences, Polymers
- Master Thesis
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