Müller Group / Laboratory for Bone Biomechanics

Open Opportunities

Bone’s Interpretation of Local Mechanical Signals ETH Zurich Müller Group / Laboratory for Bone Biomechanics The osteocyte lacunar network within bone is responsible for sensing mechanical signals, transducing them to biological signals, and orchestrating bone remodeling. Yet, the details of mechanical sensation are not understood and we must approach this topic computationally on the microscopic level. Engineering and Technology, Medical and Health Sciences Internship, Master Thesis, Semester Project

In-vivo Quantification of Dorsal Collapse during Fracture Healing of the Distal Radius ETH Zurich Müller Group / Laboratory for Bone Biomechanics Registered, time-lapse in-vivo images of distal radius fractures provide the opportunity to investigate the link between the micromechanical environment and undesired patient outcomes (i.e. dorsal tilt, shortening of the radius, etc.) within the first year post-fracture. Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences Bachelor Thesis, Internship, Master Thesis, Semester Project

Designer Hydrogels to Probe Bone Mechanobiology ETH Zurich Müller Group / Laboratory for Bone Biomechanics Living tissues remodel themselves to adapt to their mechanical environment using self-assembled fibrillar proteins. By contrast, conventional synthetic materials lack this property. This project aims to build self-assembled, mechano-responsive fibrillar gels to study bone mechanobiology. Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Macromolecular Chemistry, Materials Engineering, Organic Chemistry Master Thesis, Semester Project

Novel Bioink Synthesis for 3D Bioprinting ETH Zurich Müller Group / Laboratory for Bone Biomechanics 3D bioprinting is a state of the art additive manufacturing technique that has revolutionized tissue engineering strategies. The goal of this project is to design a bioink, compatible with bioprinting able to support the formation of cell secreted collagen. Biomaterials, Chemistry, Materials Engineering, Medical and Health Sciences Bachelor Thesis, Internship, Master Thesis, Semester Project

Image-Registration in Fractured Bone ETH Zurich Müller Group / Laboratory for Bone Biomechanics Image registration is an essential tool in bone research, yet existing software can only deal with easy geometries like healthy bone or single fractures. Therefore, the present study will investigate possibilities to register 3D images with higher geometrical complexity. Engineering and Technology, Information, Computing and Communication Sciences Bachelor Thesis, Master Thesis, Semester Project

Phenotyping and Histological Confirmation of Fluorescent Reporter Mouse Model for Osteoblasts ETH Zurich Müller Group / Laboratory for Bone Biomechanics Osteoblasts that encode specific endogenous proteins fused to a fluorescent reporter protein can be rapidly created through CRISPR/Cas9 genome editing.These, molecularly charachtarized fluorescently tagged osteoblasts will be used to study bone mechanomics Biochemistry and Cell Biology, Biomechanics, Biotechnology Bachelor Thesis, Internship, Lab Practice, Master Thesis, Semester Project

Computational Analysis and Optimization of Loading Scenarios for Scaffold-Mechanostimulation ETH Zurich Müller Group / Laboratory for Bone Biomechanics Scaffolds with show huge potential to improve fracture healing by enabling bone mineralization through appropriate structure and mechanical properties. Bone mineralization can be even enhanced through mechanical loading. Biomedical Engineering, Materials Engineering, Mechanical and Industrial Engineering Semester Project

3D bioprinting of magnetic nanocomposite cell-laden scaffolds for bone regeneration ETH Zurich Müller Group / Laboratory for Bone Biomechanics In this study, 3D magnetic nanocomposite cell-laden scaffolds will be fabricated by 3D bioprinting in order to study the influence of magnetic nanoparticles (MNPs) on cell viability, cell proliferation and osteogenic differentiation. Biotechnology, Materials Engineering Bachelor Thesis, Internship, Master Thesis, Semester Project

3D bioprinting of cell-laden mineralized silk fibroin biomimetic scaffold for bone tissue engineering ETH Zurich Müller Group / Laboratory for Bone Biomechanics Natural bone is a living and complex tissue with various types of cells and nanohybrid organic-inorganic components. In this project, we try to fabricate cell-laden biomineralized silk fibroin composite scaffolds to mimic natural bone tissue using 3D bioprinting technique. Biology, Engineering and Technology, Medical and Health Sciences Bachelor Thesis, Internship, Master Thesis, Semester Project

A Quantitative Kinetic Model for Genes Regulatory Network Using Single-Cell Mechanomics ETH Zurich Müller Group / Laboratory for Bone Biomechanics Cell signalling pathways are important regulators of bone growth and remodelling. Yet, a quantitative detailed understanding of these molecular processes is still missing in the context of bone biology. The goal of this project is to model quantitatively the kinetics of the genes regulatory network. Biochemistry and Cell Biology, Biomechanics, Computational Biology and Bioinformatics, Genetics Internship, Master Thesis, Semester Project