Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesPoor revascularization of the injury site during bone healing can severely delay or even prevent formation of new bone tissue. This project aims to use a multiscale, multiphysics model to study what factors influence the formation of blood vessels during bone healing. - Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences
- Internship, Master Thesis
| Cell signalling pathways are important regulators of bone growth and remodelling. Yet, a quantitative detailed understanding of these molecular processes is still missing in the context of bone biology. The goal of this project is to model quantitatively the kinetics of the genes regulatory network. - Biochemistry and Cell Biology, Biomechanics, Computational Biology and Bioinformatics, Genetics
- Internship, Master Thesis, Semester Project
| Osseointegration is the direct structural and functional integration of a living bone at the implant surface. Here, we aims to 3D print bone organoids on medical grade titanium (Ti) implants, in order to develop an in vitro model of biomaterial osseointegration. - Engineering and Technology, Medical and Health Sciences
- Internship, Master Thesis
| The osteocyte lacunar network within bone is responsible for sensing mechanical signals, transducing them to biological signals, and orchestrating bone remodeling. Yet, the details of mechanical sensation are not understood and we must approach this topic computationally on the microscopic level. - Engineering and Technology, Medical and Health Sciences
- Internship, Master Thesis, Semester Project
| Registered, time-lapse in-vivo images of distal radius fractures provide the opportunity to investigate the link between the micromechanical environment and undesired patient outcomes (i.e. dorsal tilt, shortening of the radius, etc.) within the first year post-fracture. - Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Living tissues remodel themselves to adapt to their mechanical environment using self-assembled fibrillar proteins. By contrast, conventional synthetic materials lack this property. This project aims to build self-assembled, mechano-responsive fibrillar gels to study bone mechanobiology. - Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Macromolecular Chemistry, Materials Engineering, Organic Chemistry
- Master Thesis, Semester Project
| 3D bioprinting is a state of the art additive manufacturing technique that has revolutionized tissue engineering strategies. The goal of this project is to design a bioink, compatible with bioprinting able to support the formation of cell secreted collagen. - Biomaterials, Chemistry, Materials Engineering, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Image registration is an essential tool in bone research, yet existing software can only deal with easy geometries like healthy bone or single fractures. Therefore, the present study will investigate possibilities to register 3D images with higher geometrical complexity. - Engineering and Technology, Information, Computing and Communication Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| Scaffolds with show huge potential to improve fracture healing by enabling bone mineralization through appropriate structure and mechanical properties. Bone mineralization can be even enhanced through mechanical loading. - Biomedical Engineering, Materials Engineering, Mechanical and Industrial Engineering
- Semester Project
| In this study, 3D magnetic nanocomposite cell-laden scaffolds will be fabricated by 3D bioprinting in order to study the influence of magnetic nanoparticles (MNPs) on cell viability, cell proliferation and osteogenic differentiation. - Biotechnology, Materials Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
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