Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesCurrent tissue engineering strategies fail to recreate the complex architecture of bone where 3D interconnected osteocytes reside in the lacuno-canalicular system to sense mechanical signals to regulate bone remodeling. We aim to create 3D-printed living osteocyte networks as mini-bone-organs. - Biochemistry and Cell Biology, Biomaterials, Interdisciplinary Engineering, Macromolecular Chemistry, Mechanical and Industrial Engineering, Medical and Health Sciences, Polymers
- Master Thesis, Semester Project
| A fundamental question in bone biology is how osteocytes magnify tissue-level mechanical strains to cell-level strains to elicit a biochemical response. This project aims to develop a tool for on-chip mechanical stimulation of 3D hydrogels to study signal transduction in osteocyte mechanosensation. - Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Macromolecular Chemistry, Materials Engineering, Organic Chemistry
- Master Thesis, Semester Project
| Bone marrow tissues are essential for sustained production of blood cellular components, the continuous remodeling of bone and efficient immune responses. This project aims to investigate the mechano-regulation of mesenchymal, hematopoietic and vascular systems in the bone marrow microenvironment. - Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Poor revascularization of the injury site during bone healing can severely delay or even prevent formation of new bone tissue. This project aims to use a multiscale, multiphysics model to study what factors influence the formation of blood vessels during bone healing. - Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences
- Internship, Master Thesis
| Bone cells that fused to fluorescent proteins can be rapidly created through CRISPR/Cas9 genome editing technology.This, fluorescently tagged osteoclasts and osteoblasts can be used to study bone mechanomics in vivo. - Biology, Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, ETH Organization's Labels (ETHZ), Internship, Master Thesis, Semester Project
| This project aims to investigate the incorporation and simulation of cyclic dynamic loading in a validated in silico load-adaptive bone adaptation algorithm. - Biology, Biomechanical Engineering, Image Processing, Interdisciplinary Engineering, Mechanical Engineering, Medical Biotechnology, Simulation and Modelling
- Bachelor Thesis, Internship, Semester Project
| In this study, 3D magnetic nanocomposite cell-laden scaffolds will be fabricated by 3D bioprinting in order to study the influence of magnetic nanoparticles (MNPs) on cell viability, cell proliferation and osteogenic differentiation. - Biotechnology, Materials Engineering
- Bachelor Thesis, Internship, Semester Project
| Natural bone is a living and complex tissue with various types of cells and nanohybrid organic-inorganic components. In this project, we try to fabricate cell-laden biomineralized silk fibroin composite scaffolds to mimic natural bone tissue using 3D bioprinting technique. - Biology, Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| This project aims at developing a biomimetic polymer nanocomposite scaffold for enhanced bone regeneration in critical sized fractures. - Biomaterials, Biomechanical Engineering, Mechanical Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Cell signalling pathways are important regulators of bone growth and remodelling. Yet, a quantitative detailed understanding of these molecular processes is still missing in the context of bone biology. The goal of this project is to model quantitatively the kinetics of the genes regulatory network. - Biochemistry and Cell Biology, Biomechanics, Computational Biology and Bioinformatics, Genetics
- Internship, Master Thesis, Semester Project
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