Müller Group / Laboratory for Bone Biomechanics

Open Opportunities

Image-Registration in Fractured Bone ETH Zurich Müller Group / Laboratory for Bone Biomechanics Image registration is an essential tool in bone research, yet existing software can only deal with easy geometries like healthy bone or single fractures. Therefore, the present study will investigate possibilities to register 3D images with higher geometrical complexity. Engineering and Technology, Information, Computing and Communication Sciences Bachelor Thesis, Master Thesis, Semester Project

Phenotyping and Histological Confirmation of Fluorescent Reporter Mouse Model for Osteoblasts ETH Zurich Müller Group / Laboratory for Bone Biomechanics Osteoblasts that encode specific endogenous proteins fused to a fluorescent reporter protein can be rapidly created through CRISPR/Cas9 genome editing.These, molecularly charachtarized fluorescently tagged osteoblasts will be used to study bone mechanomics Biochemistry and Cell Biology, Biomechanics, Biotechnology Bachelor Thesis, Internship, Lab Practice, Master Thesis, Semester Project

Computational Analysis and Optimization of Loading Scenarios for Scaffold-Mechanostimulation ETH Zurich Müller Group / Laboratory for Bone Biomechanics Scaffolds with show huge potential to improve fracture healing by enabling bone mineralization through appropriate structure and mechanical properties. Bone mineralization can be even enhanced through mechanical loading. Biomedical Engineering, Materials Engineering, Mechanical and Industrial Engineering Semester Project

3D bioprinting of magnetic nanocomposite cell-laden scaffolds for bone regeneration ETH Zurich Müller Group / Laboratory for Bone Biomechanics In this study, 3D magnetic nanocomposite cell-laden scaffolds will be fabricated by 3D bioprinting in order to study the influence of magnetic nanoparticles (MNPs) on cell viability, cell proliferation and osteogenic differentiation. Biotechnology, Materials Engineering Bachelor Thesis, Internship, Master Thesis, Semester Project

3D bioprinting of cell-laden mineralized silk fibroin biomimetic scaffold for bone tissue engineering ETH Zurich Müller Group / Laboratory for Bone Biomechanics Natural bone is a living and complex tissue with various types of cells and nanohybrid organic-inorganic components. In this project, we try to fabricate cell-laden biomineralized silk fibroin composite scaffolds to mimic natural bone tissue using 3D bioprinting technique. Biology, Engineering and Technology, Medical and Health Sciences Bachelor Thesis, Internship, Master Thesis, Semester Project

A Quantitative Kinetic Model for Genes Regulatory Network Using Single-Cell Mechanomics ETH Zurich Müller Group / Laboratory for Bone Biomechanics Cell signalling pathways are important regulators of bone growth and remodelling. Yet, a quantitative detailed understanding of these molecular processes is still missing in the context of bone biology. The goal of this project is to model quantitatively the kinetics of the genes regulatory network. Biochemistry and Cell Biology, Biomechanics, Computational Biology and Bioinformatics, Genetics Internship, Master Thesis, Semester Project

In-vivo Quantification of Bone Remodeling in Fracture Healing ETH Zurich Müller Group / Laboratory for Bone Biomechanics Registered time-lapse in-vivo images of fractures of the radius and scaphoid can be used to quantify structural changes during the fracture healing process. By combining this data with clinical imaging and blood-based biomarkers, we hope to identify the specific metrics relevant to fracture healing. Biomechanical Engineering, Image Processing, Orthopaedics Bachelor Thesis, Internship, Master Thesis, Semester Project

Quantification of Trabecular Bone Morphology using Correspondence-based Shape Modeling Techniques ETH Zurich Müller Group / Laboratory for Bone Biomechanics Existing methods to quantify trabecular bone structure utilize unnecessary classifications and, as a result, ignore the shape-based morphology of the microstructure. In contrast, this project combines 3D morphological quantification with correspondence-based shape analysis to elucidate the trabecul Biomechanical Engineering, Image Processing, Orthopaedics, Pattern Recognition Bachelor Thesis, Internship, Master Thesis, Semester Project

Mechano-regulation of cellular interplay between mesenchymal, hematopoietic and vascular systems in the bone marrow microenvironment ETH Zurich Müller Group / Laboratory for Bone Biomechanics Bone marrow tissues are essential for sustained production of blood cellular components, the continuous remodeling of bone and efficient immune responses. This project aims to investigate the mechano-regulation of mesenchymal, hematopoietic and vascular systems in the bone marrow microenvironment. Engineering and Technology, Medical and Health Sciences Bachelor Thesis, Internship, Master Thesis, Semester Project

Mapping bone cells in vivo within their 3D environment ETH Zurich Müller Group / Laboratory for Bone Biomechanics Bone remodeling is a dynamic process that requires coordinated interactions between different bone cell types. In order to further our understanding in bone metabolism, these cellular networks and their micro-environments must be investigated locally in a site specific manner. Biology, Engineering and Technology, Medical and Health Sciences Bachelor Thesis, Lab Practice, Master Thesis, Semester Project