Müller Group / Laboratory for Bone Biomechanics

Open Opportunities

Development and validation of a new scaling method to enable clinical use of advanced in silico bone models ETH Zurich Müller Group / Laboratory for Bone Biomechanics Our in silico models accurately evaluate bone strength based on patient scans and simulate disease and treatment but are not applied widely as they are computationally intensive. This project aims to develop a method to select representative subregions to facilitate clinical use. Biomechanical Engineering, Clinical Engineering Bachelor Thesis, Master Thesis, Semester Project

In silico bone adaptation simulations of mouse caudal vertebra ETH Zurich Müller Group / Laboratory for Bone Biomechanics This project aims to investigate the incorporation and simulation of cyclic dynamic loading in a validated in silico load-adaptive bone adaptation algorithm. Biology, Biomechanical Engineering, Image Processing, Interdisciplinary Engineering, Mechanical Engineering, Medical Biotechnology, Simulation and Modelling Bachelor Thesis, Internship, Semester Project

Bone’s Interpretation of Local Mechanical Signals ETH Zurich Müller Group / Laboratory for Bone Biomechanics The osteocyte lacunar network within bone is responsible for sensing mechanical signals, transducing them to biological signals, and orchestrating bone remodeling. Yet, the details of mechanical sensation are not understood and we must approach this topic computationally on the microscopic level. Engineering and Technology, Medical and Health Sciences Master Thesis

Mechanoregulation of diabetic bone remodelling using HRpQCT in vivo patient data ETH Zurich Müller Group / Laboratory for Bone Biomechanics Diabetes mellitus is a widespread metabolic disease, which disrupts the entire organism of patients. This also significantly affects bone health. The consequences are an increased risk of fractures and a worse healing of bone fractures. Biomaterials, Biomechanical Engineering, Chemical Engineering, Clinical Engineering, Clinical Sciences, Computer Hardware, Physics Bachelor Thesis, Collaboration, Internship, Master Thesis, Semester Project, Student Assistant / HiWi

3D-Printed mini-Bone-Organs ETH Zurich Müller Group / Laboratory for Bone Biomechanics Current tissue engineering strategies fail to recreate the complex architecture of bone where 3D interconnected osteocytes reside in the lacuno-canalicular system to sense mechanical signals to regulate bone remodeling. We aim to create 3D-printed living osteocyte networks as mini-bone-organs. Biochemistry and Cell Biology, Biomaterials, Interdisciplinary Engineering, Macromolecular Chemistry, Mechanical and Industrial Engineering, Medical and Health Sciences, Polymers Master Thesis, Semester Project

On-chip Mechanical Stimulation to Dissect Bone Mechanobiology ETH Zurich Müller Group / Laboratory for Bone Biomechanics A fundamental question in bone biology is how osteocytes magnify tissue-level mechanical strains to cell-level strains to elicit a biochemical response. This project aims to develop a tool for on-chip mechanical stimulation of 3D hydrogels to study signal transduction in osteocyte mechanosensation. Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Macromolecular Chemistry, Materials Engineering, Organic Chemistry Master Thesis, Semester Project

Mechano-regulation of cellular interplay between mesenchymal, hematopoietic and vascular systems in the bone marrow microenvironment ETH Zurich Müller Group / Laboratory for Bone Biomechanics Bone marrow tissues are essential for sustained production of blood cellular components, the continuous remodeling of bone and efficient immune responses. This project aims to investigate the mechano-regulation of mesenchymal, hematopoietic and vascular systems in the bone marrow microenvironment. Engineering and Technology, Medical and Health Sciences Bachelor Thesis, Internship, Master Thesis, Semester Project

Multiphysics Modeling of Revascularization during Bone Healing ETH Zurich Müller Group / Laboratory for Bone Biomechanics Poor revascularization of the injury site during bone healing can severely delay or even prevent formation of new bone tissue. This project aims to use a multiscale, multiphysics model to study what factors influence the formation of blood vessels during bone healing. Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences Internship, Master Thesis

CRISPR/Cas mediated fluorescent mouse model for osteoclasts ETH Zurich Müller Group / Laboratory for Bone Biomechanics Bone cells that fused to fluorescent proteins can be rapidly created through CRISPR/Cas9 genome editing technology.This, fluorescently tagged osteoclasts and osteoblasts can be used to study bone mechanomics in vivo. Biology, Engineering and Technology, Medical and Health Sciences Bachelor Thesis, ETH Organization's Labels (ETHZ), Internship, Master Thesis, Semester Project

Engineered bone for fracture healing ETH Zurich Müller Group / Laboratory for Bone Biomechanics This project aims at developing a biomimetic polymer nanocomposite scaffold for enhanced bone regeneration in critical sized fractures. Biomaterials, Biomechanical Engineering, Mechanical Engineering Bachelor Thesis, Internship, Master Thesis, Semester Project