Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesThis project aims to develop an automated pipeline to localise bone cells from histology slices. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Electrical and Electronic Engineering, Interdisciplinary Engineering, Mathematics, Mechanical and Industrial Engineering, Medical Biotechnology, Statistics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Cell signalling pathways are important regulators of bone growth and remodelling. Yet, a quantitative detailed understanding of these molecular processes is still missing in the context of bone biology. The goal of this project is to model quantitatively the kinetics of the genes regulatory network. - Biochemistry and Cell Biology, Biomechanics, Computational Biology and Bioinformatics, Genetics
- Internship, Master Thesis, Semester Project
| Adapt a model of treatment of osteoporosis with denosumab over 10 years to model treatment of osteoporosis with alendronate over 9 years. - Medical and Health Sciences
- Master Thesis
| Bone remodeling is a continuous metabolic cycle of bone resorption and formation to maintain homeostasis. Several studies have reported how mechanical loading influences bone structure in a gender-dependent manner. However, how the mechanostat affects the bone cells and their microenvironment remain - Biochemistry and Cell Biology, Biotechnology
- ETH Organization's Labels (ETHZ), Internship, Lab Practice, Master Thesis, Semester Project
| Bone cells that fused to fluorescent proteins can be rapidly created through CRISPR/Cas9 genome editing technology.This, fluorescently tagged osteoclasts and osteoblasts can be used to study bone mechanomics in vivo. - Biology, Engineering and Technology, Medical and Health Sciences
- ETH Organization's Labels (ETHZ), Internship, Master Thesis, Semester Project, Student Assistant / HiWi
| The osteocyte lacunar network within bone is responsible for sensing mechanical signals, transducing them to biological signals, and orchestrating bone remodeling. Yet, the details of mechanical sensation are not understood and we must approach this topic computationally on the microscopic level. - Engineering and Technology, Medical and Health Sciences
- Master Thesis
| Bone adapts to withstand its habitual mechanical loading environment by adapting its microstructure through bone forming and resorbing cells. This project aims to quantify bone mechanoregulation in cancellous and cortical bone of the human distal radius by using new high-resolution CT imaging. - Biology, Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| We use high-resolution patient imaging to monitor bone’s mechanically driven remodelling process. In FIDELIO, we are now working with clinicians at the University of Sheffield and computer scientists at IBM to improve the care of diabetic patients. - Biology, Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| Current tissue engineering strategies fail to recreate the complex bone architecture where 3D interconnected osteocytes reside in the lacuno-canalicular system for mechano-regulation of bone remodeling. This project aims to create functional osteocyte networks as in vitro bone model for medicine. - Biochemistry and Cell Biology, Biomaterials, Interdisciplinary Engineering, Macromolecular Chemistry, Mechanical and Industrial Engineering, Medical and Health Sciences, Polymers
- Master Thesis, Semester Project
| Delayed fracture repair and formation of non-unions is a major issue in orthopedic surgery. In order to better understand the complex mechanism of mechano-molecular regulation of fracture repair and to assess potential treatment approaches, we use standardized preclinical defect models in mice. - Biomaterials
- Bachelor Thesis, Internship, Master Thesis, Semester Project
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