Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesAdapt a model of treatment of osteoporosis with denosumab to model treatment of osteoporosis with a bisphosphonate (e.g. zoledronate). - Medical and Health Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| in vitro 3D bioprinted bone organoids with appropriate mechanical properties pose new opportunities to investigate bone biology and mechanics. This student project will focus on developing a padding method to enable running micro FE on CT-images of bone organoids and researching mechano-regulation. - Biomechanical Engineering, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Mechanical loading can accelerate or impair bone healing. Our lab has developed an in vivo experimental setup that permits gait analysis and deformation measurements within a bone fracture in mice. The aim of this project is to analyse data sets from both healthy young mice and prematurely aged mice - Biomechanical Engineering
- Bachelor Thesis, Internship, Semester Project
| We fluorescently tagged osteoclasts and osteoblasts to study in vivo bone mechanomics. This project aims to characterize fluorescent osteoclasts and osteoblasts to understand molecular changes in bone microenvironment. - Biology, Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Collaboration, Internship, Lab Practice, Master Thesis, Semester Project, Student Assistant / HiWi
| Age-dependent alterations in bone remodeling changes the activity of bone cells result in diseases like osteoporosis. This project aims to investigate the degenerative effects of aging on bone cells in prematurely aged mice. - Biology, Biomedical Engineering, Medical and Health Sciences
- Bachelor Thesis, ETH Organization's Labels (ETHZ), Internship, Lab Practice, Master Thesis, Semester Project, Student Assistant / HiWi
| Develop and implement new algorithms governing the growth and the optimisation of vascular networks using a multiphysics agent-based model. - Biomechanical Engineering, Information, Computing and Communication Sciences, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Cell signalling pathways are important regulators of bone growth and remodelling. Yet, a quantitative detailed understanding of these molecular processes is still missing in the context of bone biology. The goal of this project is to model quantitatively the kinetics of the genes regulatory network. - Biochemistry and Cell Biology, Biomechanics, Computational Biology and Bioinformatics, Genetics
- Internship, Master Thesis, Semester Project
| A fundamental question in bone biology is how osteocytes magnify tissue-level mechanical strains to cell-level strains to elicit a biochemical response. This project aims to develop a tool for on-chip mechanical stimulation of 3D hydrogels to study signal transduction in osteocyte mechanosensation. - Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Interdisciplinary Engineering, Macromolecular Chemistry, Manufacturing Engineering, Materials Engineering
- Master Thesis, Semester Project
| 3D bioprinting is a state of the art additive manufacturing technique that has revolutionized tissue engineering strategies. The goal of this project is to 3D bioprint and analyse a cell-laden bone tissue engineering scaffold. - Engineering and Technology, Medical and Health Sciences
- Internship, Master Thesis, Semester Project
| This project aims to develop an automated pipeline to localise bone cells from histology slices. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Electrical and Electronic Engineering, Interdisciplinary Engineering, Mathematics, Mechanical and Industrial Engineering, Medical Biotechnology, Statistics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
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