Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesIn this study, 3D magnetic nanocomposite cell-laden scaffolds will be fabricated by 3D bioprinting in order to study the influence of magnetic nanoparticles (MNPs) on cell viability, cell proliferation and osteogenic differentiation. - Biotechnology, Materials Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Delayed fracture repair and formation of non-unions is a major issue in orthopedic surgery. In order to better understand the complex mechanism of mechano-molecular regulation of fracture repair and to assess potential treatment approaches, we use standardized preclinical defect models in mice. - Biomaterials
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Scaffolds with show huge potential to improve fracture healing by enabling bone mineralization through appropriate structure and mechanical properties. Bone mineralization can be even enhanced through mechanical loading. - Biomedical Engineering, Materials Engineering, Mechanical and Industrial Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Over the last decade, work on development of tissue organoids using 3D bioprinting (3DP) has been at the forefront of medical research. 3DP technique provides the ability to manufacture reproducible 3D structures with well-defined spatial cell location. High fidelity 3DP of cell-laden scaffolds depe - Biology, Chemistry, Engineering and Technology
- Internship, Semester Project
| In vitro 3D bone organoids aim to bridge the gap existing with current in vitro models (often on a 2D or represented by a single cell type) and in vivo situations. By definition organoid means resembling an organ this implies: multiple tissue-specific cell types, recapitulation some specific functio - Cell Development (incl. Cell Division and Apoptosis), Protein Targeting and Signal Transduction
- Internship, Master Thesis, Semester Project
| 3D bioprinting is an emerging technology that open new perspectives for tissue/organ biofabrication but also for biofabrication of relevant in vitro models to study tissue physiology. Printing properties and the physico-chemical properties of the ink must support cell survival and functionality. - Cell Development (incl. Cell Division and Apoptosis), Cell Metabolism, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Membrane Biology, Molecular interactions, Protein Targeting and Signal Transduction
- Master Thesis
| 3D bioprinting is a state of the art additive manufacturing technique that has revolutionized tissue engineering strategies. The goal of this project is to design a cooling device able to create a stable printing environment to improve current printing capabilities. - Engineering and Technology
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Living tissues remodel themselves to adapt to their mechanical environment using self-assembled fibrillar proteins. By contrast, conventional synthetic materials lack this property. This project aims to build biomimetic hydrogels that respond to mechanical stress through self-adaptation. - Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Macromolecular Chemistry, Materials Engineering, Organic Chemistry
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| The vasculature has in important influence on the bone homeostasis. Yet a deep understanding of this mechanism is missing. The aim of this project is to develop an in silico model capturing the interplay between vasculature remodelling and bone physiological activity. - Biomechanical Engineering
- Master Thesis, Semester Project
| Marrow adipocytes play an important role in the bone remodelling process by enhancing bone resorption. Nevertheless, a model that studies both the bone remodelling process and adipocytes is still missing. The goal of this project is to analyse how the adipocytes are related to the bone multicellular units. - Biomechanical Engineering
- Master Thesis, Semester Project
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