Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesThe osteocyte lacunar network within bone is responsible for sensing mechanical signals, transducing them to biological signals, and orchestrating bone remodeling. Yet, the details of mechanical sensation are not understood and we must approach this topic computationally on the microscopic level. - Engineering and Technology, Medical and Health Sciences
- Internship, Master Thesis, Semester Project
| Existing tissue engineering strategies fail to recreate the key structural features of bone tissues which present a hierarchical organization over different length scales. Here we seek to utilize high-resolution 3D-printing technique to sculpture bone-like 3D cell environments for disease modeling. - Biomedical Engineering, Biotechnology, Cell Development (incl. Cell Division and Apoptosis), Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Chemical Engineering, Interdisciplinary Engineering, Manufacturing Engineering, Materials Engineering, Mechanical and Industrial Engineering, Medical Biotechnology, Medicine-general, Pharmacology and Pharmaceutical Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Registered time-lapse in-vivo images of fractures of the radius and scaphoid can be used to quantify structural changes during the fracture healing process. By combining this data with clinical imaging and blood-based biomarkers, we hope to identify the specific metrics relevant to fracture healing. - Biomechanical Engineering, Image Processing, Orthopaedics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Existing methods to quantify trabecular bone structure utilize unnecessary classifications and, as a result, ignore the shape-based morphology of the microstructure. In contrast, tThis project combines 3D morphological quantification with correspondence-based shape analysis to elucidate the trabecul - Biomechanical Engineering, Image Processing, Orthopaedics, Pattern Recognition
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Bone marrow tissues are essential for sustained production of blood cellular components, the continuous remodeling of bone and efficient immune responses. This project aims to investigate the mechano-regulation of mesenchymal, hematopoietic and vascular systems in the bone marrow microenvironment. - Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Bone remodeling is a dynamic process that requires coordinated interactions between different bone cell types. In order to further our understanding in bone metabolism, these cellular networks and their micro-environments must be investigated locally in a site specific manner. - Biology, Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Lab Practice, Master Thesis, Semester Project
| A number of mouse loading models exist to study bone adaptation and regeneration. However, the loading conditions and strains that act on bones vary between the models. The aim of this project is to compare the loading parameters and the strain distribution in two animal models by means of FEA. - Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| With our current computational framework, it is possible to simulate physiological processes in bone at the single cell scale. In this project the effect of pharmaceutical intervention during postmenopausal osteoporosis will be investigated. - Biomechanical Engineering
- Internship, Master Thesis, Semester Project, Student Assistant / HiWi
| Assessing the mechanical properties of healed mouse femurs with three point bending tests poses a challenge due to certain test artifacts. Implementation of an experimental, imaging and computational approach will allow accurate determination of these properties. - Biomedical Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| During our bone fracture healing experiments, we implant an external fixator. Understanding this fixators behavior and incorporating its implant geometries into our boundary conditions is a key step in understanding the strain in the mechanical environment during healing. - Biomechanical Engineering, Mechanical Engineering
- Bachelor Thesis, Master Thesis, Semester Project
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