Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesDelayed fracture repair and formation of non-unions is a major issue in orthopedic surgery. In order to better understand the complex mechanism of mechano-molecular regulation of fracture repair and to assess potential treatment approaches, we use standardized preclinical defect models in mice. - Biomaterials
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Bone remodeling is a continuous metabolic cycle of bone resorption and formation to maintain homeostasis. Several studies have reported how mechanical loading influences bone structure in a gender-dependent manner. However, how the mechanostat affects the bone cells and their microenvironment remain - Biochemistry and Cell Biology, Biotechnology
- ETH Organization's Labels (ETHZ), Internship, Lab Practice, Master Thesis, Semester Project
| Fluorescently labeled bone cells used for investigating bone mechanomics can be generated via CRISPR/Cas9 technology. However, off-target mutations need to be detected to provide solid genotype-phenotype correlations - Biochemistry and Cell Biology, Biotechnology, Genetics
- ETH Organization's Labels (ETHZ), Internship, Lab Practice, Semester Project
| Bone cells that fused to fluorescent proteins can be rapidly created through CRISPR/Cas9 genome editing technology.This, fluorescently tagged osteoclasts and osteoblasts can be used to study bone mechanomics in vivo. - Biology, Engineering and Technology, Medical and Health Sciences
- ETH Organization's Labels (ETHZ), Internship, Master Thesis, Semester Project, Student Assistant / HiWi
| Poor revascularization of the injury site during bone healing can severely delay or even prevent formation of new bone tissue. This project aims to use a multiscale, multiphysics model to study what factors influence the formation of blood vessels during bone healing. - Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences
- Internship, Master Thesis
| 3D-bioprinted bone scaffolds show vast potential by enabling bone mineralization in vitro. The progress of bone mineralization is assessed by micro-CT imaging followed by image processing. We want to improve the detection of mineralized bone to obtain a more accurate scaffold structure. - Biomechanical Engineering, Image Processing
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Osseointegration is the direct structural and functional integration of a living bone at the implant surface. Here, we aims to 3D print bone organoids on medical grade titanium (Ti) implants, in order to develop an in vitro model of biomaterial osseointegration. - Engineering and Technology, Medical and Health Sciences
- Internship, Master Thesis
| This project aims to develop an automated pipeline to localise bone cells from histology slices. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Electrical and Electronic Engineering, Interdisciplinary Engineering, Mathematics, Mechanical and Industrial Engineering, Medical Biotechnology, Statistics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| To investigate bone mechanoregulation in diabetic patients, a deep learning-based method for high-resolution reconstruction of trabecular microstructures from low-resolution HR-pQCT scans using GAN-CIRCLE will be developed - Biomedical Engineering, Mechanical and Industrial Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| Our in silico models accurately evaluate bone strength based on patient scans and simulate disease and treatment but are not applied widely as they are computationally intensive. This project aims to develop a method to select representative subregions to facilitate clinical use. - Biomechanical Engineering, Clinical Engineering
- Bachelor Thesis, Master Thesis, Semester Project
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