Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesIn vitro 3D bone organoids aim to bridge the gap existing with current in vitro models (often on a 2D or represented by a single cell type) and in vivo situations. By definition organoid means resembling an organ this implies: multiple tissue-specific cell types, recapitulation some specific functio - Cell Development (incl. Cell Division and Apoptosis), Protein Targeting and Signal Transduction
- Internship, Master Thesis, Semester Project
| The osteocyte lacunar network within bone is responsible for sensing mechanical signals, transducing them to biological signals, and orchestrating bone remodeling. Yet, the details of mechanical sensation are not understood and we must approach this topic computationally on the microscopic level. - Engineering and Technology, Medical and Health Sciences
- Internship, Master Thesis, Semester Project
| Living tissues remodel themselves to adapt to their mechanical environment using self-assembled fibrillar proteins. By contrast, conventional synthetic materials lack this property. This project aims to build self-assembled, mechano-responsive fibrillar gels as dynamic extracellular matrix mimics. - Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Macromolecular Chemistry, Materials Engineering, Organic Chemistry
- Master Thesis, Semester Project
| Registered, time-lapse in-vivo images of distal radius fractures provide the opportunity to investigate the link between the micromechanical environment and undesired patient outcomes (i.e. dorsal tilt, shortening of the radius, etc.) within the first year post-fracture. - Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Existing tissue engineering strategies fail to recreate the architecture and function of bone tissues which present a hierarchical organization over different length scales. Here we propose to apply high-resolution 3D-printing to sculpture mini-bone-organs in a petri dish. - Biochemistry and Cell Biology, Biomaterials, Interdisciplinary Engineering, Macromolecular Chemistry, Mechanical and Industrial Engineering, Medical and Health Sciences, Polymers
- Master Thesis, Semester Project
| Registered time-lapse in-vivo images of fractures of the radius and scaphoid can be used to quantify structural changes during the fracture healing process. By combining this data with clinical imaging and blood-based biomarkers, we hope to identify the specific metrics relevant to fracture healing. - Biomechanical Engineering, Image Processing, Orthopaedics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Existing methods to quantify trabecular bone structure utilize unnecessary classifications and, as a result, ignore the shape-based morphology of the microstructure. In contrast, tThis project combines 3D morphological quantification with correspondence-based shape analysis to elucidate the trabecul - Biomechanical Engineering, Image Processing, Orthopaedics, Pattern Recognition
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Bone marrow tissues are essential for sustained production of blood cellular components, the continuous remodeling of bone and efficient immune responses. This project aims to investigate the mechano-regulation of mesenchymal, hematopoietic and vascular systems in the bone marrow microenvironment. - Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Bone remodeling is a dynamic process that requires coordinated interactions between different bone cell types. In order to further our understanding in bone metabolism, these cellular networks and their micro-environments must be investigated locally in a site specific manner. - Biology, Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Lab Practice, Master Thesis, Semester Project
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