Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesOur goal is to establish a heterocellular 3D printed bone organoid model comprising all major bone cell types (osteoblasts, osteocytes, osteoclasts) to recapitulate bone remodeling units in an in vitro system. The organoids will be produced with the human cells, as they could represent human pathophysiology better than animal models, and eventually could replace them. These in vitro models could be used in the advancement of next-generation personalised treatment strategies. Our tools are different kinds of 3D bioprinting platforms, bio-ink formulations, hydrogels, mol-bioassays, and time-lapsed image processing of micro-CT scans. - Biomaterials, Biomechanical Engineering, Cell Development (incl. Cell Division and Apoptosis), Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Polymers
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| Develop and test a micro-Multiphysics Agent-Based (micro-MPA) model to simulate cellular interactions and mechanical stimuli during bone regeneration and adaptation.
- Engineering and Technology
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| The proposed project will investigate the trabecular bone response to estrogen depletion and will be used to investigate the probability of the chosen mechanism of action for estrogen. The chosen mechanism of action will be validated using available experimental reference data. - Biomechanics, Programming Techniques
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| To date, there is still very limited progress in developing organoid models for human musculoskeletal tissues such as bone. A major challenge is reconstructing the native bone microenvironment which is structurally and functionally complex. In this project, we leverage interdisciplinary advances in tissue engineering and microtechnologies to generate a microengineered bone-organoid-on-chip platform for both fundamental and translational research in medicine. - Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Interdisciplinary Engineering, Macromolecular Chemistry, Manufacturing Engineering, Materials Engineering
- Internship, Master Thesis, Semester Project
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