Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesFracture healing is a complex process that involves inflammation, angiogenesis, and bone remodeling. The remodelling process helps maintain bone density, repair micro-damage that occurs due to everyday activities, and adapt bones to the specific needs of an individual's body. Mechanical loading is a crucial factor in the regulation of fracture healing. The forces and strains experienced by the bone during everyday activities influence the cellular responses, callus formation, bone deposition, remodelling, and, ultimately, the successful recovery of the fractured bone. The mechanisms underlying spatial cell reorganization during loading, which contributes to fracture healing, remain unclear. The project aims to investigate and explore the fracture healing process of mice using spatial transcriptome changes in response to mechanical loading. By shedding light on this aspect, the project aims to contribute to the broader understanding of fracture healing and potentially pave the way for more effective treatment strategies in the future. - Biological Mathematics, Computational Biology and Bioinformatics, Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences, Physics
- Bachelor Thesis, Course Project, ETH for Development (ETH4D) (ETHZ), ETH Zurich (ETHZ), IDEA League Student Grant (IDL), Internship, Master Thesis, Semester Project
| The project aims at investigating the influence of osteoporosis and the effect of different pharmacological treatments and mechanical loading on osteocyte lacunar properties and void spaces in vertebral bone in 3D.
This can be achieved by registering high (1.2 µm) to low (10.5 µm) resolution microCT images and running morphological analyses. - Biomedical Engineering, Medical and Health Sciences
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| This project aims to develop an automated pipeline to localise bone cells from histology slices. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Electrical and Electronic Engineering, Interdisciplinary Engineering, Mathematics, Mechanical and Industrial Engineering, Medical Biotechnology, Statistics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| This project endeavors to explore the dynamic interplay among calcium ions, bone graft substitutes, and resident immune cells in both orthotopic and ectopic environments, employing advanced ratiometric imaging techniques. - Biomaterials, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Our goal is to establish a heterocellular 3D printed bone organoid model comprising all major bone cell types (osteoblasts, osteocytes, osteoclasts) to recapitulate bone remodeling units in an in vitro system. The organoids will be produced with the human cells, as they could represent human pathophysiology better than animal models, and eventually could replace them. These in vitro models could be used in the advancement of next-generation personalised treatment strategies. Our tools are different kinds of 3D bioprinting platforms, bio-ink formulations, hydrogels, mol-bioassays, and time-lapsed image processing of micro-CT scans. - Biomaterials, Biomechanical Engineering, Cell Development (incl. Cell Division and Apoptosis), Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Polymers
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| Develop and test a micro-Multiphysics Agent-Based (micro-MPA) model to simulate cellular interactions and mechanical stimuli during bone regeneration and adaptation.
- Engineering and Technology
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| The proposed project will investigate the trabecular bone response to estrogen depletion and will be used to investigate the probability of the chosen mechanism of action for estrogen. The chosen mechanism of action will be validated using available experimental reference data. - Biomechanics, Programming Techniques
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| To date, there is still very limited progress in developing organoid models for human musculoskeletal tissues such as bone. A major challenge is reconstructing the native bone microenvironment which is structurally and functionally complex. In this project, we leverage interdisciplinary advances in tissue engineering and microtechnologies to generate a microengineered bone-organoid-on-chip platform for both fundamental and translational research in medicine. - Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Interdisciplinary Engineering, Macromolecular Chemistry, Manufacturing Engineering, Materials Engineering
- Internship, Master Thesis, Semester Project
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