Müller Group / Laboratory for Bone BiomechanicsOpen OpportunitiesAdapt a model of treatment of osteoporosis with denosumab, PTH, bisphosphonates or romosozumab to explore sequential and branching simulations and identify optimal sequential and combinatorial drug treatments - Medical and Health Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| Mechanical loading can accelerate or impair bone healing. Our lab has developed an in vivo experimental setup that permits gait analysis and deformation measurements within a bone fracture in mice. The aim of this project is to analyse data sets from both healthy young mice and prematurely aged mice - Biomechanical Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| We use state-of-the-art 3D high-resolution imaging to study the properties of nanoscopic structures in bone. This project combines microCT imaging with advanced computational modelling and bone biology to advance our understanding of the mechanisms that lead to bone loss due to aging and disease. - Biomechanical Engineering, Image Processing, Radiology and Organ Imaging, Software Engineering
- Master Thesis, Semester Project
| We use high-resolution patient imaging to monitor bone’s mechanically driven remodelling process. In FIDELIO, we are now working with clinicians at the University of Sheffield and computer scientists at IBM to improve the care of diabetic patients.
- Chemistry, Engineering and Technology, Mathematical Sciences, Medical and Health Sciences, Physics
- Bachelor Thesis, Course Project, Master Thesis, Semester Project
| This project aims to develop an automated pipeline to localise bone cells from histology slices. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Electrical and Electronic Engineering, Interdisciplinary Engineering, Mathematics, Mechanical and Industrial Engineering, Medical Biotechnology, Statistics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Delayed bone healing or failed non-unions account for 5 – 10% of all bone fractures and present a challenging problem in regenerative medicine. The impact of delayed unions or non-unions can be devastating with prolonged rehabilitation, decreased quality of life and significant health care costs. Our lab has conducted fracture healing studies in young and prematurely-aged mouse models with different defect sizes. The aim of this project is to analyse data from mice which exhibit delayed unions and non-unions. - Engineering and Technology
- Bachelor Thesis, Internship, Semester Project
| Age-related bone loss and associated fractures result in osteoporosis, a major problem for the elderly. Several studies suggested as a therapeutic target to prevent bone loss by precise coordination of bone remodeling through the interaction of bone cells namely: osteoclast-bone resorbing cells, osteoblasts-bone forming cells and osteocytes-key mechanosensors of bone remodeling. To understand the cellular mechanism of aging, this project investigates the degenerative changes in the bone cells in a mouse model of senile osteoporosis. - Biology, Biomedical Engineering, Medical and Health Sciences
- Bachelor Thesis, ETH Organization's Labels (ETHZ), Internship, Lab Practice, Master Thesis, Other specific labels, Semester Project
| Osteocytes are known to regulate bone mass with aging due to their central role in mechanotransduction and the expression of important molecular markers to orchestrate the bone remodeling process. Because osteocytes are not easily accessible as they are embedded within a deep mineralized matrix, therefore our understanding of bone remodeling with aging is incomplete. In this project, we investigate the changes in the osteocyte networks with aging by investigating the morphology of the lacunocanalicular network (LCN) through histological staining, confocal imaging and image analysis tools.
- Biology, Engineering and Technology, Medical and Health Sciences
- Bachelor Thesis, Course Project, Internship, Lab Practice, Master Thesis, Semester Project
| This project aims to develop a pipeline to register 2D histological images to 3D micro-CT images. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Interdisciplinary Engineering, Materials Engineering, Mathematical Sciences, Mathematical Software, Mechanical and Industrial Engineering, Medical and Health Sciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
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