Real-time control of focused ultrasound intensities using passive cavitation detection (PCD): applications to targeted drug delivery

• ETH Zurich
• Neurotechnology

Non-invasive, focal drug delivery in a controlled, reliable manner can lead to breakthroughs in the treatment of brain disorders. We recently developed a unique technology based on focused ultrasounds that allows for the efficient delivery of small molecules to specific brain targets. Yet, ensuring safe and effective transmission of ultrasound energy is challenging in the presence of highly-aberrating media like the skull. This project will involve the development of closed-loop algorithms and hardware for the adaptive, real-time control of ultrasound intensities during therapy. This will ensure maximally-effective drug delivery while minimizing potential harm to the target tissue.

• Engineering and Technology, Medical and Health Sciences
• Master Thesis, Semester Project