Balgrist University HospitalOpen OpportunitiesWe are looking for a dynamic and proactive research software engineer to advance the impact of open-source software for musculoskeletal image analysis - Software Engineering
- Internship
| The main tract for transmitting noxious stimuli is the spinothalamic tract, receiving its input from different types of small fibers in the skin i.e., mechanical- or heat-sensitive fibers. In spinal cord injury as in other pathologies involving neuropathic pain and sensation deficits, it is crucial to assess spinothalamic tract integrity with objective methods. This depends on a well-characterized stimulation modality, activating small fibers, and implies the recording of brain activity in response to this stimulation (electroencephalography; EEG).1 Intra-epidermal electrical stimulation (IES) using a concentric triple electrode is known for its clinical potential due to small fiber activation and is a good candidate for the activation of the spinothalamic tract.2 However, to implement IES as a diagnostic tool in the clinical routine, feasibility, and test-retest reliability need to be assessed compared to other stimulation modalities.3–5 - Central Nervous System, Peripheral Nervous System, Sensory Systems, Systems Physiology
- Course Project, Internship, Master Thesis, Semester Project
| The goal of this project is to develop new algorithms to characterize cortical and trabecular bone structures from PCD-CT. To this end, we aim to (1) combine novel ideas with established methods [1,2], and (2) to define the basics for a new open-source workflow to process bone images from PCD-CT. - Biomedical Engineering
- Internship, Master Thesis, Semester Project
| Extensive remote structural changes of the spinal cord and brain occur in the first months following spinal cord injury (SCI), with faster degenerative changes relating to poorer recovery. However, the spatial and temporal patterns of progression along the neuro-axis, and their relation to the clinical course of SCI are still understudied. We utilize advanced quantitative MRI methods to better reveal tissue macro- and microstructural changes, to determine a more defined analysis of changes along the whole CNS, (i.e., within but also below and above the cord lesion), and to characterize the injury-induced changes affecting the myelin and axonal architecture.
The specific aim is to apply novel, cutting edge ultra-high resolution qMRI methods (multi-parametric mapping such as T1 quantification, R2* and diffusion weighted MRI methods) on the ultra-high field 7T MR scanner to assess microstructural changes and impairment with high accuracy and sensitivity. - Clinical Engineering, Neurosciences
- Collaboration, Master Thesis, Semester Project
| The Department of Neuro-Urology at the Spinal Cord Injury Center, University of Zürich and Balgrist University Hospital in Zürich, Switzerland, is offering a PhD positions for a highly motivated and scientifically interested PhD candidate to conduct clinical research joining neuroimaging with neuro-urology in humans. This position is embedded in an interdisciplinary research environment team of health care professionals, neuroscientists, physicists, biologists, human movement scientists, pharmacologists, and engineers. You will be involved in a nation-wide randomized, sham-controlled, double-blind clinical trial investigating transcutaneous tibial nerve stimulation in patients with acute spinal cord injury to prevent neurogenic detrusor overactivity (http://p3.snf.ch/Project-179644, supported by the Swiss National Science Foundation (SNSF) and the Swiss Paraplegics Foundation (SPS). - Medical and Health Sciences
- PhD Placement
| The autonomic nervous system reacts to pain, for example by adapting the heart rate or increased sweat output at the hands. Such pain-autonomic responses have been shown to be increased in chronic pain patients with a sensitized nociceptive system (Scheuren et al., 2023). However, pain-autonomic responses can also be influenced be positive and negative expectations (Aslaksen et al., 2008; Rhudy et al., 2018). Therefore, we aim to disentangle the effects of expectations and sensitization on pain-autonomic responses. For this reason, we will conduct a study in healthy participants, using experimentally induced sensitization and a placebo paradigm. - Biology, Medical and Health Sciences
- Internship, Master Thesis
| We are looking for highly motivated and scientifically interested master candidates to conduct clinical research joining neurophysiology and neuroimaging with neuro-urology in humans. This post is embedded in the research environment of the Department of Neuro-Urology and the Spinal Cord Injury Center, University of Zürich, and Balgrist University Hospital in Zürich, where you will be working in an interdisciplinary team of health care professionals, neuroscientists, physicists, biologists, human movement scientists, pharmacologists, and electrical engineers. - Clinical Sciences, Neurosciences
- Master Thesis
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