![](/files/organization-images/ceeff2b7-9c9f-41fb-b0f6-dcec828d24cc/3b0477b9-a0c4-4c8d-83ad-e5066b42ef66.png_200_200.png) Department of Biosystems Science and EngineeringAcronym | D-BSSE | Homepage | http://www.bsse.ethz.ch/ | Country | Switzerland | ZIP, City | | Address | | Phone | | Type | Academy | Parent organization | ETH Zurich | Current organization | Department of Biosystems Science and Engineering | Child organizations | |
Open OpportunitiesRett syndrome (RETT) is a rare neurodevelopmental disorder linked to mutations in the MECP2 gene on the X chromosome. For a deeper understanding of how these mutations relate to neuronal function and the observed range of symptoms in patients, we set out to develop an integrated multimodal phenotypic screening approach. To do so we want to stablish a 3D hiPSCs-derived control/mutant neuronal cultures using a combination of functional and molecular biology assays, genomics assays , including high-throughput high-density microelectrode array (HD-MEA) measurements, patch clamp recordings, and protein expression analyses. - Biology, Neurosciences
- Master Thesis
| iPSC-derived neuronal cultures is a valuable tool for studying and understanding diverse neurodevelopmental disorders. By observing their functional activity at both the network level and single-cell level, we can gain insights into the electrophysiological properties of neurons. This approach allows us to compare the disease model with its control counterpart, thereby identifying differences and similarities that could shed light on the underlying mechanisms. - Cell Development (incl. Cell Division and Apoptosis), Systems Biology and Networks
- Bachelor Thesis, Internship
| The student will culture neurons on a microelectrode array, and will record the electrical activity of the network and follow its evolution over time. The development of new methods for signal processing, neuron stimulation, and imaging can be included in the project depending on the experience and interests of the student. - Biology, Biomedical Engineering, Engineering/Technology Instrumentation, Neurosciences
- Bachelor Thesis, Course Project, Lab Practice, Master Thesis, Semester Project
| The student will develop an FPGA-based platform for interacting with in-vitro neuronal cultures, including real-time spike detection and neuron stimulation. The project is focused on VHDL programming, although it could include other software development and/or wet-lab tasks with neurons depending on the interests of the student. - Electrical and Electronic Engineering, Neurosciences
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| This project is about the development of integrated circuits to study neurons and neural networks, and may comprise different parts of the design including analog and/or digital microelectronics, PCB design, signal processing and programming. - Electrical and Electronic Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| The student will be involved in the development of software applications for in-vitro neural interfaces. The ultimate goal is controlling a complex embedded system, comprising a custom-made CMOS neural interface and two system on a chip. - Electrical Engineering, Engineering/Technology Instrumentation, Mathematical Software, Programming Languages, Programming Techniques, Software Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Organoids are attractive model systems to study aspects of the developing mammalian brain in vitro. In this project, we will use high-density microelectrode arrays to study the emerging neuronal networks in healthy and diseased mouse brain organoids - Biology, Engineering and Technology, Medical and Health Sciences
- Master Thesis, Semester Project
| Electrophysiological recording systems, such as patch-clamp rigs and in-vitro neural interfaces, are designed to capture minute voltage signals (<100 µV) produced by electrogenic cells. These systems often comprise multiple instruments that face electromagnetic compatibility challenges, including ground loops and conflicting electric and magnetic fields. This project seeks to investigate the underlying causes of these issues and develop solutions to enhance the reliability and robustness of electrophysiological recordings. - Biosensor Technologies, Electrical Engineering, Engineering/Technology Instrumentation
- Master Thesis, Semester Project
| The focus of this project is on the fabrication of microelectrodes for advanced neural interfaces in a cutting-edge cleanroom environment. Our research aims to develop high-resolution neural probes utilizing state-of-the-art microfabrication techniques. - Biomedical Engineering, Biosensor Technologies, Mechanical Engineering, Nanotechnology
- Master Thesis, Semester Project
| This project focuses on the design of low-noise, low-power, compact amplifiers for next-generation neural interfaces. - Integrated Circuits
- Master Thesis, Semester Project
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