Institute for BiomechanicsOpen OpportunitiesThe Biomaterials Engineering (BME) group of Professor Xiao-Hua Qin is recruiting 1-2 Master Thesis students in micro-tissue chip development. - Biomedical Engineering, Mechanical and Industrial Engineering
- ETH Zurich (ETHZ), IDEA League Student Grant (IDL), Lab Practice, Master Thesis, Semester Project
| Fracture healing is a complex process that involves inflammation, angiogenesis, and bone remodeling. The remodelling process helps maintain bone density, repair micro-damage that occurs due to everyday activities, and adapt bones to the specific needs of an individual's body. Mechanical loading is a crucial factor in the regulation of fracture healing. The forces and strains experienced by the bone during everyday activities influence the cellular responses, callus formation, bone deposition, remodelling, and, ultimately, the successful recovery of the fractured bone. The mechanisms underlying spatial cell reorganization during loading, which contributes to fracture healing, remain unclear. The project aims to investigate and explore the fracture healing process of mice using spatial transcriptome changes in response to mechanical loading. By shedding light on this aspect, the project aims to contribute to the broader understanding of fracture healing and potentially pave the way for more effective treatment strategies in the future. - Biological Mathematics, Computational Biology and Bioinformatics, Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences, Physics
- Bachelor Thesis, Course Project, ETH for Development (ETH4D) (ETHZ), ETH Zurich (ETHZ), IDEA League Student Grant (IDL), Internship, Master Thesis, Semester Project
| The project aims at investigating the influence of osteoporosis and the effect of different pharmacological treatments and mechanical loading on osteocyte lacunar properties and void spaces in vertebral bone in 3D.
This can be achieved by registering high (1.2 µm) to low (10.5 µm) resolution microCT images and running morphological analyses. - Biomedical Engineering, Medical and Health Sciences
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| This project aims to develop an automated pipeline to localise bone cells from histology slices. - Biomedical Engineering, Computational Biology and Bioinformatics, Computer Hardware, Electrical and Electronic Engineering, Interdisciplinary Engineering, Mathematics, Mechanical and Industrial Engineering, Medical Biotechnology, Statistics
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| This project endeavors to explore the dynamic interplay among calcium ions, bone graft substitutes, and resident immune cells in both orthotopic and ectopic environments, employing advanced ratiometric imaging techniques. - Biomaterials, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Understanding the differences in spine kinematics between patients with lumbar spinal stenosis and those with healthy spines, along with the implications for spinal loading, could shed light on the pathophysiology of this disease and contribute to the development of more effective treatment and rehabilitation strategies. To estimate spinal loads, a novel full-body musculoskeletal model developed in AnyBody Modeling System will be used. This model will be customized to reflect subject-specific spinal alignment and will be driven by kinematic data obtained from in vivo motion-capture measurements. Inverse dynamics simulations of patient-specific spinal postures and forward flexion trials will be performed to estimate the corresponding loads. - Biomechanics
- ETH Zurich (ETHZ), Master Thesis
| Our goal is to establish a heterocellular 3D printed bone organoid model comprising all major bone cell types (osteoblasts, osteocytes, osteoclasts) to recapitulate bone remodeling units in an in vitro system. The organoids will be produced with the human cells, as they could represent human pathophysiology better than animal models, and eventually could replace them. These in vitro models could be used in the advancement of next-generation personalised treatment strategies. Our tools are different kinds of 3D bioprinting platforms, bio-ink formulations, hydrogels, mol-bioassays, and time-lapsed image processing of micro-CT scans. - Biomaterials, Biomechanical Engineering, Cell Development (incl. Cell Division and Apoptosis), Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Polymers
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| The Laboratory of Orthopedic Technology has recently developed a novel joint implant and is undergoing optimization of the manufacturing process. We are looking for a master's student who is passionate about medical devices and mechanical design to join us for a semester project.
Objectives:
• Design different molds for material casting using SolidWorks or Fusion 360.
• Optimize implant design using matlab or Python.
• Mechanical testing of the implant including fatigue test.
Your Profile:
• Strong knowledge in mechanical design and drawing skills.
• Hands-on and detail-oriented.
• Experience with SolidWorks or Fusion 360, as well as Python or Matlab. - Biomechanical Engineering
- ETH Zurich (ETHZ), Semester Project
| The Laboratory of Orthopedic Technology at ETH Zurich is currently optimizing the manufacturing process for a novel joint implant. We are looking for a master's student who is passionate about medical devices and polymer science to join our team for a semester project or master's thesis.
Project Focus: The selected candidate will work on optimizing the performance of a hydrogel material that is a key component of the cartilage replacement implant. The project will involve:
• Investigating polymer synthesis and formulation techniques to enhance hydrogel performance.
• Developing testing protocols to evaluate the hydrogel’s effectiveness in mimicking natural cartilage behavior.
- Organic Chemical Synthesis
- ETH Zurich (ETHZ), Master Thesis, Semester Project
| Develop and test a micro-Multiphysics Agent-Based (micro-MPA) model to simulate cellular interactions and mechanical stimuli during bone regeneration and adaptation.
- Engineering and Technology
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
|
|
