Institute for BiomechanicsOpen OpportunitiesJoin a dynamic research team at the intersection of biomechanics, tissue engineering, and cell biology. This project offers hands-on training in state-of-the-art methods to investigate how tendon tissue responds to injury, disease processes, and mechanical stimulation during exercise-based therapy. - Biomedical Engineering
- Master Thesis
| Controlling fluid flow is essential in various natural and engineering systems, with geometry playing a fundamental role in shaping fluid behavior. However, the interaction between geometry and flow behavior remains a complex phenomenon, primarily governed by the flow regime and fluid material properties.
Certain geometries, whether naturally occurring or engineered, induce direction-dependent flow resistance, causing variations in velocity and flow rate in opposite directions. One well-known example of such engineered geometries is the Tesla valve—a passive device without moving parts, designed to create asymmetric flow resistance, particularly at high Reynolds numbers. This structure acts like a fluidic diode, offering greater resistance to flow in one direction by generating turbulent vortices and flow separations while allowing smoother movement in the opposite direction. This effect is quantified by diodicity, which represents the ratio of pressure drop in the reverse direction to that in the forward direction, providing a measure of the valve's asymmetric resistance. However, this direction dependence is limited at lower velocities.
We have designed two sets of geometries that effectively induce directional flow resistance within high and low fluid flow velocities. This Master’s thesis project aims to experimentally investigate the impact of different flow obstruction designs on direction-dependent resistance in rectangular channels and semicircular arc segments. The student will, together with their direct supervisor, design and construct an experimental setup for the reliable measurement of flow and diodicity. This project offers an excellent opportunity to gain expertise in fluid dynamics, experimental testing, numerical modeling, and additive manufacturing, with applications in biomedical systems.
Students with a background in mechanical engineering, fluid dynamics, or related fields are encouraged to apply. Prior experience with COMSOL Multiphysics is beneficial but not mandatory.
- Mechanical Engineering
- Master Thesis
| Our goal is to establish a heterocellular 3D printed bone organoid model comprising all major bone cell types (osteoblasts, osteocytes, osteoclasts) to recapitulate bone remodeling units in an in vitro system. The organoids will be produced with the human cells, as they could represent human pathophysiology better than animal models, and eventually could replace them. These in vitro models could be used in the advancement of next-generation personalised treatment strategies. Our tools are different kinds of 3D bioprinting platforms, bio-ink formulations, hydrogels, mol-bioassays, and time-lapsed image processing of micro-CT scans. - Biomaterials, Biomechanical Engineering, Cell Development (incl. Cell Division and Apoptosis), Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Polymers
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| In over 100 years, the remarkable ability of bone to adapt to its mechanical environment has been a source of scientific fascination. Bone regeneration has been shown to be highly dependent on the mechanical environment at the fracture site. It has been demonstrated that mechanical stimuli can either accelerate or impede regeneration. Despite the fundamental importance of the mechanical environment in influencing bone regeneration, the molecular mechanisms underlying this phenomenon are complex and poorly understood. - Biomedical Engineering, Medical Physiology
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| The project aims at investigating material-induced osteoinduction using the available mouse model of orthotopic or ectopic bone graft substitute (BGS) application. Through the 3D-3D registration of ex vivo and in vivo multiscale micro-CT images, crucial 3D mineralization behavior of the BGS can be investigated. - Biomedical Engineering, Medical and Health Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| Versive, an ETH Spinoff in formation, is developing innovative manual wheelchairs using their disruptive "steering-by-leaning" principle (as seen here: https://www.youtube.com/watch?v=HrJFH3MLlaw ). Currently, we're planning a market launch at the end of 2026 or beginning of 2027.
As part of an iterative design process, we need to be able to run essential durability tests ensuring a quick CE marking (medical device class 1) procedure later on. Besides static stability, flammability and biocompatibility, the ISO tests require mechanical durability testing. These include a rolling test (several days on a roller, under load) as well as a drop test (6666 drops from 15cm, fully loaded). For this, we are looking to implement our own testing infrastructure. - Care for Disabled, Engineering/Technology Instrumentation, Health Care Administration, Mechanical Engineering
- Collaboration, Internship, Lab Practice, Student Assistant / HiWi
| The Biomaterials Engineering (BME) group of Professor Xiao-Hua Qin is hiring an ERC-funded PhD student in tissue microfabrication. - Biomedical Engineering, Materials Engineering, Mechanical and Industrial Engineering
- ETH Zurich (ETHZ), PhD Placement
| This project endeavors to explore the dynamic interplay among calcium ions, bone graft substitutes, and resident immune cells in both orthotopic and ectopic environments, employing advanced ratiometric imaging techniques. - Biomaterials, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Background:
Lower back pain is one of the most prevalent health issues in Switzerland, with severe socio-economic consequences and a leading cause of reduced work performance. Approximately 20% of spinal fusion surgeries performed using off-the-shelf implants result in the surgical outcome being compromised post-operatively, often requiring one or more revision surgeries to address the associated pain.
The Laboratory of Orthopedic Technology has recently developed a novel spinal implant using topology optimization, which is currently undergoing a feasibility study for clinical applications.
We are seeking a master’s student who is passionate about medical devices and mechanical design and testing to join us for a semester project or master thesis. In this role, you will gain insight into the spinal surgery process, receive input from surgeons, and contribute to the mechanical design and testing of the implant.
Objectives:
• Perform the CT scan on animal vertebrae
• Evaluate the influence of implant placement/location variability
• Mechanical testing on the implant
• Develop surgical tools if needed
Your Profile:
• Strong knowledge in mechanical design and drawing skills.
• Hands-on and detail-oriented.
• Experience with SolidWorks or Fusion 360, as well as Python or Matlab.
Timeframe:
Spring semester in 2025
- Orthopaedics
- Master Thesis, Semester Project
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