The late fetal and neonatal stage is critical for brain development. In the clinical practice, it is often very difficult to quantify any lag or acceleration compared to the normal developmental trajectory. In some disorders, such as in intrauterine growth retardation or congenital heart disorders, estimating the “developmental brain age” would be of critical practical importance. 3D ResNets have previously been used to evaluate brain age in elderly subjects mainly in the context of Alzheimer’s disease. In early brain development, their use is not well documented. In this project, the thesis student will implement a 3D ResNet or similar architecture that estimates brain developmental age on 3D MRI data.
- Biomedical Engineering, Computer Vision, Medical and Health Sciences
- Course Project, Internship, Lab Practice, Master Thesis, Semester Project
Among pediatric neoplasms, central nervous system (CNS) tumors represent the leading cause of mortality and morbidity in pediatric and young adult patients. BRAFV600E is an oncogenic mutation and targetable alteration in gliomas, the most common brain tumors across ages. Blocking the Ras/BRAF/MAPK pathway is a promising strategy in BRAFV600E-positive tumours. However, treatment failure often ensues due to acquired resistance to targeted inhibitors.
In our laboratory we have identified key pathways driving resistance to BRAFV600E inhibitors. Using a multi-omic approach (transcriptomics and proteomics), a master student will focus on exploring and targeting these resistance mechanisms, in order to optimize treatment strategies.
- Oncology and Carcinogenesis
- Master Thesis
We are inviting applicants to apply for an SNSF Swiss Postdoctoral Fellowship to join our research group. The research project would be hosted at the University of Zürich in Switzerland. The fellowship is the Swiss equivalent of the prestigious Marie-Sklodowska Curie Postdoctoral Fellowship. After the selection of one or two promising candidates and identification of the focus of research, we will support you in the application process.
- Artificial Intelligence and Signal and Image Processing, Biomedical Engineering, Neurosciences
- Post-Doc Position