**SiROP is an exclusive network of leading universities in science and technology**
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- Hundreds of open positions readily available online
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- **PhD positions, MSc, BSc, and internships in Biology and Biotechnology.** **SiROP is an exclusive network of leading universities in science and technology**
Why join SiROP?
- Hundreds of open positions readily available online
- Direct contact and easy application procedure without any bureaucracy
- **PhD positions, MSc, BSc, and internships in Biology and Biotechnology.** Profit from a great search interface and directly apply to the position of your choice. SiROP - Excellence in Science! Profit from a great search interface and directly apply to the position of your choice. SiROP - Excellence in Science! Selection of open positions in **Biology and Biotechnology** Selection of open positions in **Biology and Biotechnology** This project explores the integration of haptic feedback mechanisms into robotic microsurgery, focusing on neurosurgical applications. The aim is to enhance the surgeon’s ability to perceive tool-tissue interaction through telemanipulated systems. The work includes analyzing current sensing technologies, developing a hybrid hardware-software interface for haptic interaction, and evaluating the impact of tactile feedback on surgical performance in delicate environments. - Biomechanical Engineering, CAD/CAM Systems, Mechanical Engineering, Robotics and Mechatronics
- Master Thesis, Semester Project
| The goal of the project is to develop wearable devices, for use in environmental electromagnetic energy recovery based on human body application. - Biomedical Engineering, Electrical and Electronic Engineering, Materials Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| The remarkable complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space. To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cellular nanomechanics such as tension forces and bioelectromagnetics) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
In this framework we are investigating the unacknowledged key role of Desmoglein 3 (Dsg3) as a receptor involved in mechanosensing, capable of initiating a signaling response in the transcellular communication network, which results in stem cell fate conversion, plasticity and tissue repair.
Our goal is to apply innovative Fluidic Force Microscopy to measure altered biophysical parameters upon disruption of Dsg3 transadhesion such as cell stiffness, cell-cell adhesion, cell surface charges and electric potentials. Together with the University of Bern and University of Lübeck we are further investigating how these biophysical changes relate to transcriptomic, epigenomic and proteomic response circuits to ultimately infer biophysical and biochemical circuits involved in Dsg3 signaling.
- Biochemistry and Cell Biology, Biomedical Engineering, Medical and Health Sciences, Physics
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| The key energy substrates of the brain are glucose and oxygen. Both are delivered to the brain via an intricate
network of blood vessels. Recently, novel datasets resolving the entire vasculature of the mouse brain became
available, which offer unique opportunities to study the brain’s energy supply. This requires developing and
applying novel numerical methods to simulate blood flow and nutrient transport in large microvascular networks
and the surrounding tissue. Besides looking at the healthy brain we are interested in pathologies like stroke and
Alzheimer’s disease. - Biomedical Engineering, Mechanical Engineering
- Internship, Master Thesis, Semester Project, Student Assistant / HiWi
| Diaxxo, an innovative ETH Zürich spinoff, is transforming diagnostics with cutting-edge PCR technology that combines lab-grade accuracy with field-ready simplicity. Our mission is to enable faster, affordable, and accessible detection of viral and bacterial infections, driving impact in animal health, food safety, and human diagnostics.
We are seeking a motivated Hardware Engineer (electrical / mechatronics) to join our team in Zürich, starting May 2025 (or a mutually agreed date). This role involves contributing to the design and assembly of devices and cartridges and quality control. It’s an excellent opportunity to gain hands-on experience in a dynamic startup environment while supporting our mission to revolutionize diagnostics. No specific experience is required—just motivation, commitment, and adaptability. - Biomedical Engineering, Chemical Engineering, Chemistry, Electrical Engineering, Manufacturing Engineering, Mechanical Engineering, Medical and Health Sciences
- Collaboration, ETH Zurich (ETHZ), Internship, Post-Doc Position, Student Assistant / HiWi
| The goal of the project is to develop metal oxide-based logic electronics, for use in rectification and/or memristor application. - Biomedical Engineering, Electrical and Electronic Engineering, Materials Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| Rotator cuff tears are a common shoulder injury. Some people only have a few symptoms, so that a tear cannot be diagnosed in some cases. This can lead to consequential damage and wear, e.g. tendon injuries or osteoarthritis. We therefore want to find out what influence changes in the shape of the shoulder bones have on shoulder biomechanics during activities of daily living. In this study, subjects with shoulder tendon injuries and control subjects are included and examined in the Laboratory for Functional Biomechanics at the University Hospital Basel using questionnaires, arm movement analysis, muscle strength measurements and imaging techniques. - Biomechanics, Biomedical Engineering
- Internship
| Join a dynamic research team at the intersection of biomechanics, tissue engineering, and cell biology. This project offers hands-on training in state-of-the-art methods to investigate how tendon tissue responds to injury, disease processes, and mechanical stimulation during exercise-based therapy. - Biomedical Engineering
- Master Thesis
| Facial expression plays an important role in human communication, providing a variety of non-verbal cues. Neural stimulation and recording can be used to restore facial functions and improve quality of life of people with facial paralysis. - Biomedical Engineering, Peripheral Nervous System, Surgery
- Master Thesis
| In this project, you will explore how cells generate mechanical forces using confocal traction force microscopy (cTFM). The project combines experimental techniques, such as cell culturing, quantum dot array printing, and live-cell confocal imaging, together with computational data analysis using the open-source tool Cellogram. By growing cells on deformable substrates and tracking the displacement of fluorescent quantum dots, students will quantify the traction forces that individual cells exert on their environment. - Biology, Engineering and Technology, Information, Computing and Communication Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| Peripheral intraneural stimulation can provide tactile information to amputees. However, efforts are still necessary to identify encoding strategy eliciting percepts that are felt as both natural and effective for prosthesis control. Here we want to develop neural modulation strategies able to improve the naturalness and efficacy of stimulation to convey sensory information to trans-femoral amputees implanted with intraneural electrodes. - Electrical Engineering, Peripheral Nervous System, Rehabilitation Engineering, Sensory Systems
- Master Thesis
| Inclusion bodies are dense protein aggregates formed in the cytoplasm of bacteria like E. coli. While often regarded as problematic, proteins that are sequestered in such inclusion bodies continue to be active and are simple to purify. By tagging proteins of interest with specific “inclusion body tags”, even proteins that would remain soluble can be sequestered into inclusion bodies upon expression.
This project aims to design and evaluate novel inclusion body tags with tailored properties for diverse applications. Of special interest are tags that are detectable in electrospray ionization mass spectrometry (ESI-MS). - Analytical Chemistry, Biochemistry and Cell Biology, Biotechnology, Microbiology, Structural Biology
- Master Thesis
| We are currently looking for Master’s students with background in machine learning (or related computational field) for a project on Protein Fitness Optimization. - Artificial Intelligence and Signal and Image Processing, Computational Structural Biology
- Master Thesis, Semester Project
| This project aims to develop a deep learning model to automate the identification of DNA replication intermediates (RIs) in high-resolution Transmission Electron Microscopy (TEM) images—a process currently reliant on manual review. Leveraging a rich dataset from the Lopes lab at the University of Zurich, the model will classify image tiles containing RIs and rank them by prediction confidence to streamline analysis. The project also includes implementing interpretability tools to uncover features associated with RIs. It is ideal for candidates with strong computational skills, experience in deep learning (e.g., PyTorch or TensorFlow), and an interest in interdisciplinary research at the interface of biology and AI. - Electronmicroscopy, Genome Structure, Image Processing, Neural Networks, Genetic Alogrithms and Fuzzy Logic, Protein Targeting and Signal Transduction, Systems Biology and Networks
- Internship, Master Thesis
| Engineered muscle tissues have applications in regenerative medicine, drug testing, and understanding motion. A key challenge is restoring neuromuscular communication, especially in treating volumetric muscle loss (VML). This project aims to create functional neuromuscular constructs with biomimetic innervation. Scaffolds will be made using electrospun fibers, conductive materials, and drug-loaded graphene. Muscle and nerve cells derived from iPSCs will be seeded into these scaffolds. Constructs will be tested for motion, drug response, and integration in bio-hybrid robotic systems. The platform will advance muscle-nerve regeneration, drug testing, and bio-hybrid robotics. - Biology, Engineering and Technology, Medical and Health Sciences
- Master Thesis, Semester Project
| This project aims to leverage machine learning to accelerate the design of polymer-based drug delivery systems with tailored release kinetics. Using a curated dataset of polymer formulations and their drug release profiles, predictive models will be developed, validated, and applied to optimize future formulations. By combining computational tools with explainable AI techniques, the project seeks to uncover key design principles and reduce experimental workloads. The outcome will enable smarter, data-driven reformulation processes, advancing personalized medicine and next-generation drug delivery technologies. - Biomedical Engineering, Chemical Engineering, Electrical and Electronic Engineering, Industrial Biotechnology and Food Sciences, Interdisciplinary Engineering, Macromolecular Chemistry, Manufacturing Engineering, Materials Engineering, Mechanical and Industrial Engineering, Pharmacology and Pharmaceutical Sciences
- Internship, Semester Project
| Are you interested in discovering chemical reaction networks by using machine leaning approaches? And to discover new genetic circuit topologies capable of temporal signal processing and biocomputation?
Then we have the project for you! The details are below. Come join us! - Computational Biology and Bioinformatics, Control Engineering, Stochastic Analysis and Modelling
- ETH Zurich (ETHZ), Master Thesis, Semester Project
| Are you interested in what a cell look like in nanometer scale? Do you want to see how the cell behaves in real time?
Scanning ion conductance microscopy (SICM) is the non-contact SPM technology to image live cells based on glass capillaries with a nanometric aperture. It applies a voltage and measures the ionic current flowing through the pipette above the sample in the buffer solution: the recorded current represents the feedback signal to measure the topography of the sample. This project aims to characterize a state of the art high-speed SICM to enable time-resolved live cell imaging, and do the live cell imaging on human primary keratinocytes to study the related disease. - Biomedical Engineering, Electrical and Electronic Engineering, Information, Computing and Communication Sciences, Manufacturing Engineering, Mechanical Engineering, Nanotechnology
- Master Thesis
| The reintegration of individuals who have experienced accidents is at the heart of our efforts. A severe car accident or a workplace accident, can profoundly change a person's life. Such tragic events often result in serious injuries, such as severed limbs, and are classified as "polytrauma." At our lab, we are working to mitigate the consequences of such severe accidents. Using an innovative perfusion machine, we try to keep severed limbs alive outside the body for up to four days. This time window provides the foundation for successfully retransplanting the limb to a stabilized polytrauma patient. - Biomedical Engineering, Mechanical and Industrial Engineering
- ETH Zurich (ETHZ), Master Thesis
| The goal of this project is to develop an analytical method that will enable even small material samples to be tested for their suitability for the extrusion process. - CAD/CAM Systems, Chemical Engineering, Food Engineering, Food Processing, Materials Engineering, Mechanical and Industrial Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| Based on pre-study, the aim of this new thesis project is to continue the research work and further improve the die design, fabricate new die variants using AM, and experimentally test them onsite at the facilities of Planted. - CAD/CAM Systems, Chemical Engineering, Food Engineering, Food Processing, Materials Engineering, Mechanical and Industrial Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| Project Summary
We’re developing a powerful new in vitro model to untangle the complex mechanical cues—osmotic pressure and substrate stiffness—that skin cells experience every day. These signals are deeply intertwined in the body, but we’re building a system to decouple and precisely control them, for the first time. Why? Because understanding how cells respond to these forces is crucial for engineering functional tissues, guiding organ regeneration, and tackling mechanobiology-driven diseases like fibrosis.
- Biochemistry and Cell Biology, Biomaterials, Diagnostic Applications
- Master Thesis
| Introduction and Background
Skin cells dynamically respond to mechanical and biochemical stimuli, which influence critical processes such as proliferation, differentiation, and migration. By understanding this interplay, mechanical and biochemical stimuli may be used in the future to facilitate the growth of skin patches, tissue formation, and organ regeneration, enabling new therapies and benefiting patients. The study of these responses, mechanobiology, requires advanced in-vitro systems to emulate physiological conditions. This project utilizes a device designed for controlled manipulation of hydrostatic pressure (0.1–1.5 kPa) and substrate stiffness (0.1–100 kPa). The system facilitates isolated and scalable experiments to analyze how the interplay of these mechanical parameters affects cell behavior. In this thesis, the student will use this system to investigate how different stimuli affect cell behavior.
- Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Polymers
- Master Thesis
| We will build an imager based on near-infrared optical tomography (NIROT) that is able to non-invasively image brain oxygenation in preterm and term neonates. Wanted: Ph.D. student: an electrical engineer/physicist with a Masters Degree and profound knowledge in hardware (PCB design, FPGA, optical components) and software (C, C++, Matlab, VHDL) engineering. - Biomedical Engineering
- PhD Placement
| The repetitive and high-impact nature of the golf swing may contribute to lower spine degeneration and chronic low back pain. This project aims to analyze the biomechanical loading of the lumbar spine during the golf swings through advanced motion capture and modeling techniques. A high-fidelity golf simulator combined with a mobile phone-based motion capture system will be used to evaluate swing mechanics. In Part A, state-of-the-art pose estimation models will be tested for their accuracy in extracting 3D motion data from monocular videos. In part B, biomechanical analysis will integrate pose data into an individualized OpenSim model to estimate spinal joint reaction forces and muscle activity. The ultimate goal is to develop a smartphone-based tool capable of real-time swing analysis to provide insight into injury prevention and technique optimization for golfers. - Artificial Intelligence and Signal and Image Processing, Biomechanical Engineering
- Master Thesis
| Osteoarthritis (OA) presents a significant challenge in healthcare, necessitating innovative solutions to alleviate pain, enhance mobility. This thesis documents the research and development journey of an OA knee orthosis within the Spinal Cord and Artificial Intelligence Lab (SCAI-Lab) at ETH Zurich.
This thesis is a close collaboration between the ORTHO-TEAM Group and the SCAI-Lab at ETH Zurich. The collaboration offers a unique exchange of expertise and resources between industry and academia. Together, we aim to make meaningful progress in the field of and empower students to make valuable contributions to their academic pursuits.
- Biomechanics, Biomedical Engineering
- ETH Zurich (ETHZ), Master Thesis
| Our goal is to establish a heterocellular 3D printed bone organoid model comprising all major bone cell types (osteoblasts, osteocytes, osteoclasts) to recapitulate bone remodeling units in an in vitro system. The organoids will be produced with the human cells, as they could represent human pathophysiology better than animal models, and eventually could replace them. These in vitro models could be used in the advancement of next-generation personalised treatment strategies. Our tools are different kinds of 3D bioprinting platforms, bio-ink formulations, hydrogels, mol-bioassays, and time-lapsed image processing of micro-CT scans. - Biomaterials, Biomechanical Engineering, Cell Development (incl. Cell Division and Apoptosis), Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Polymers
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| In over 100 years, the remarkable ability of bone to adapt to its mechanical environment has been a source of scientific fascination. Bone regeneration has been shown to be highly dependent on the mechanical environment at the fracture site. It has been demonstrated that mechanical stimuli can either accelerate or impede regeneration. Despite the fundamental importance of the mechanical environment in influencing bone regeneration, the molecular mechanisms underlying this phenomenon are complex and poorly understood. - Biomedical Engineering, Medical Physiology
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| We invite applications for a Master's thesis / semester project that focuses on the fabrication of microrobots with custom shapes. Using our developed droplet printing technique, this project will explore how different microrobot shapes, created by different magnetic fields and materials, influence their control behaviors in blood vessels. This research aims to advance biomedical technologies, particularly in targeted drug delivery and minimally invasive procedures. - Biomedical Engineering, Colloid and Surface Chemistry, Materials Engineering, Nanotechnology, Printing Technology
- ETH Zurich (ETHZ), Master Thesis, Semester Project, Student Assistant / HiWi
| To protect from chemical, biological, radioactive, and nuclear (CBRN) contaminants, disposable coveralls are used as personal protective clothing (PPC). In addition to its protective nature, PPC affects heat dissemination from the body, resulting in increased heat strain, which might result in reduced working performance. Therefore, new clothing material developments aim to reduce thermal load while maintaining a protective nature. We conduct a wearing trial in collaboration with an industrial partner to investigate the impact of different types of protective coveralls on heat strain during exposure to warm conditions, including resting phases and physical activity. - Exercise Physiology, Human Biophysics, Physiology, Systems Physiology, Textile Technology
- Internship, Lab Practice, Master Thesis, Semester Project
| The focus of this project is on the fabrication of microelectrodes for advanced neural interfaces in a cutting-edge cleanroom environment. Our research aims to develop high-resolution neural probes utilizing state-of-the-art microfabrication techniques. - Biomedical Engineering, Biosensor Technologies, Mechanical Engineering, Nanotechnology
- Master Thesis, Semester Project
| diaxxo, a start-up from ETH Zürich, is transforming molecular diagnostics with an innovative Point-of-Care Polymerase Chain Reaction (PCR) device.
This project aims to enhance the detection module of Diaxxo's Point-of-Care Polymerase Chain Reaction (PCR) system by improving light uniformity to ensure precise and reliable optical detection. The redesigned detection block will be compatible with Diaxxo's existing cartridges and support multiplexing with up to three distinct light channels. High light uniformity across the cartridge will be a key focus to enhance detection accuracy and reliability. Additionally, the project emphasizes cost-effective design, leveraging affordable materials and methods to maintain performance without increasing production costs.
- Biomechanical Engineering, Electrical Engineering, Mechanical Engineering, Optical and Photonic Systems, Optics and Opto-electronic Physics, Optometry
- Bachelor Thesis, Master Thesis, Semester Project
| Project Title: Designing a Human-in-the-Loop Model for Behavior Classification in Videos
Description:
We are looking for a motivated student to join an exciting interdisciplinary project that combines neuroscience, machine learning, and human-computer interaction. The project involves building a robust model for behavior classification in videos with a human-in-the-loop approach. The data for this project has already been recorded, and the next steps involve integrating new data, improving the model, and implementing machine learning solutions using Python and popular ML libraries. - Biology, Engineering and Technology, Information, Computing and Communication Sciences
- Master Thesis
| The project aims at investigating material-induced osteoinduction using the available mouse model of orthotopic or ectopic bone graft substitute (BGS) application. Through the 3D-3D registration of ex vivo and in vivo multiscale micro-CT images, crucial 3D mineralization behavior of the BGS can be investigated. - Biomedical Engineering, Medical and Health Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| In this project, we propose a real-time sensorized hand-exoskeleton that combines the exosuit and the sensory feedback based on TENS systems. The integrated robotic system will be able to provide the user with assisted grasping force control via exo and with fine grip-force feedback. - Peripheral Nervous System, Rehabilitation Engineering, Therapies and Therapeutic Technology
- Master Thesis
| The project consists in assessing the degree to which our perception of natural texture is shaped by the mechanics of the skin. We have implemented an approach, developed by Ted Adelson at MIT (GelSight), that consists of fabricating a gel whose material properties match those of the skin and then imaging (using a laser profilometer) the pattern of deformation on the surface of the gel that is produced when pressed against the surface. We can then estimate how the skin would be deformed by any given texture using this approach and assess whether we can better predict from these patterns of skin deformation the responses of tactile nerve fibers to that texture and the perception thereof. - Biomedical Engineering, Central Nervous System, Sensory Systems
- Master Thesis
| Our previous studies has identified that the nature of signals recorded with electrodes implanted in the peripheral nervous system strongly depends on the type of electrode and the degree of activity inside the nerve. For this project your aim will be to further explore which dimension of a population activity a given type of electrode can identify. Based on the literature you will identify discharge patterns combination permitting to recreate the main different classes of bio-plausible population activity. You will also complete the existing hybrid model to integrate the main kinds of electrodes used with neural interfaces (use of Solidworks, Matlab, and Comsol).
You will then implement your bio-mimetic population activity in the full model and study each electrode’s dynamic selectivity. Your final goal would be to establish rules permitting to classify from the recording alone what “family” of activity is happening in the nerve.
- Biomedical Engineering, Electrical Engineering, Modeling and Simulation, Peripheral Nervous System
- Master Thesis
| Sensory feedback based on intracortical microstimulation has been shown to improve subjects’ ability to use brain-controlled bionic hands (Flesher et al., 2021). However, the resulting dexterity is still far from that of natural hands in able-bodied individuals. Efforts to sensitize bionic hands for amputees by electrical stimulation of the nerves have shown that sensory feedback that mimics natural tactile signals (so called biomimetic feedback (Okorokova et al., 2018; Saal and Bensmaia, 2015; Saal et al., 2017) evokes more natural and more intuitive sensations that better support interactions with objects than does non-biomimetic feedback. Despite these successes with amputees, biomimetic feedback has never been applied in the context brain-controlled bionic hands. - Biomedical Engineering, Central Nervous System, Electrical Engineering, Sensory Systems
- Master Thesis
| Chemical pollutants in water bodies pose a major environmental threat. Among other effects, they can affect the neurophysiology of aquatic organisms, impairing their chances of survival. Neuroactive chemicals specifically act on key central nervous system molecules, leading to adverse neurological effects. Current environmental risk assessment of neurotoxicity still largely relies on fish testing, which is not only time- and resource-intensive but also focuses primarily on behavioral changes and mortality, without providing mechanistic insights into neurotoxic effects. Here, we propose a rainbow trout (Oncorhynchus mykiss) brain cell line (RTbrain) as an animal-free alternative for the neurotoxicity assessment of environmental pollutants. - Agricultural, Veterinary and Environmental Sciences, Biology
- Master Thesis
| Are you passionate about science and sustainability? Conduct your own innovative research at the intersection of chemistry and biotechnology, pioneering the conversion of renewableresources into valuable fine chemicals. - Biology, Chemistry, Engineering and Technology
- PhD Placement
| In the BIROMED-Lab we have been developing an endoscopic system for safer neurosurgeries with inspiration from human finger anatomy. Its two degrees of freedom allow the endoscope to investigate areas of the brain that would be inaccessible with standard rigid endoscopes. Thanks to springs in the transmission between the motors and the movable endoscope tip, the interaction forces between the instrument and the brain tissue can be reduced. Furthermore the interaction forces can be estimated by measuring the deflection of the spring. To make the telemanipulation of the endoscope safer and more intuitive for the surgeon, force feedback was also implemented. - Biomedical Engineering
- Master Thesis
| EVD is a common procedure in Neurosurgery, nevertheless its placement is non-ideal in up to 40% of the cases because of lack of hands-on experience of residents. To try and solve the issue we propose a medical simulator that will merge haptic feedback with hardware components. Vibro-tactile feedback has been proven useful in medical simulations and could give a more complete and realistic experience to the training surgeon, either as supplementary information to the force feedback or as stand alone information. In order to feed back the vibro-tactile information to the user, the haptic device has to be instrumentalized with appropriate custom-made hardware. - Biomedical Engineering
- Master Thesis
| Are you intrigued by the fascinating field of nanomedicine and how it can assist the improvement of maternal and fetal health? Do you want to combine nanotechnology and human-relevant advanced cell models?
We are looking for a M.Sc. student to join the Nanomaterials in Health Lab at Empa St. Gallen. The candidate will be part of an exciting and collaborative project between Empa and the Kantonsspital St. Gallen. - Biochemistry and Cell Biology, Obstetrics and Gynaecology, Reproduction, Toxicology (incl. Clinical Toxicology)
- Master Thesis
| We are looking for a motivated Master’s student to join an exciting interdisciplinary thesis project, collaborating between the Multi-Scale Robotics Lab (D-MAVT) and the deMello group (D-CHAB) at ETH Zurich. This project focuses on creating a novel microfluidic-based bottom-up method to fabricate multifunctional microrobots. This innovative approach seeks to revolutionize microrobot fabrication, opening the door to diverse new applications. - Biomedical Engineering, Chemical Engineering, Colloid and Surface Chemistry
- ETH Zurich (ETHZ), Master Thesis
| The development of biomaterials for chronic wound healing faces significant challenges in achieving shelf-stability, transportability, and compliance with clinical manufacturing standards. To address these hurdles, we aim to integrate a freeze-drying (lyophilization) step into the preparation of our granular hydrogels, facilitating storage and transport without compromising functionality. By validating the post-rehydration performance of lyophilized microgels, we aim to ensure the robustness of our product for clinical use. - Biology, Chemistry, Medical and Health Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| Chronic wound care is hindered by the complex and variable proteomic profiles of wound exudates, which limit the efficacy of existing therapies. We aim to validate the effectiveness of our granular hydrogel platform in restoring balance to the wound microenvironment. Utilizing exudates obtained from diabetic foot ulcer (DFU) patients, we will optimize our microgel library to target clinically relevant cytokine profiles. - Biology, Chemistry, Engineering and Technology, Medical and Health Sciences
- Master Thesis, Semester Project
| Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition with high mortality rates in intensive care units, making early prediction crucial for timely interventions. This project explores Bayesian networks as an interpretable alternative to traditional machine learning models for ARDS risk prediction. By leveraging counterfactual explanations and interventional machine learning, we aim to identify actionable ventilator settings that could reduce ARDS risk. The analysis will use real-world ICU data from the University Hospital of Zurich and be externally validated on public datasets. This work bridges AI, causal inference, and clinical decision-making to enhance patient care. - Clinical Engineering, Medical and Health Sciences
- Course Project, Master Thesis, Semester Project
| We are seeking a dedicated master’s student for a thesis project focused on understanding the growth of fungi within various scaffolds, with the goal of utilizing fungi as novel food source. - Chemical Engineering, Industrial Biotechnology and Food Sciences, Materials Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| This research focuses on understanding the colloidal behaviour of bacterial spores through diverse characterization techniques. Your work will focus on characterizing ellipsoid polystyrene particles instead of Bacillus subtilis spores. The same characterization experiments had already been conducted on Bacillus subtilis spores, providing valuable experience with the required procedures.
- Biomaterials, Interdisciplinary Engineering, Materials Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project, Summer School
| Our research group aims to enhance the understanding of human language acquisition and development using songbird as model.
We are particularly interested in the evolutionary aspects of language, where two developmental tendencies are observed: convergent and divergent evolution. Convergent evolution refers to the simplification of language complexity, similar to how infants gradually acquire human language. Conversely, divergent evolution involves an increase in complexity, akin to teenagers creating and using novel words to establish unique identities. We propose to investigate whether similar effects are observable in animal vocalization learning, specifically in song learning of zebra finches and to explore the effect of social interaction.
To facilitate this investigation, our team has developed a "birdpark," a multimodal recording system that provides a naturalistic social environment for observing and recording multiple zebra finches within a dynamic group context.
- Learning, Memory, Cognition and Language, Linguistic Processes (incl. Speech Production and Comprehension), Sensory Systems, Signal Processing, Zoology
- ETH Zurich (ETHZ), Master Thesis, Semester Project
| Join our research on developing a non-invasive microfluidic device for continuous biomarker monitoring in preterm infants to eliminate the need for blood sampling. This project focuses on optimizing a probe's membrane permeability through in vitro diffusion experiments to improve microdialysis technique and neonatal healthcare. - Biomedical Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| Microorganisms that can be found everywhere in our environment are able to produce a variety of molecules from very simple precursors. Some of the products synthetized by bacteria are materials with fascinating properties such as cellulose with excellent mechanical properties. Materials produced by living cells are attractive because they are produced with minimal energy input and are based on green chemicals. Moreover, if well-designed, these materials still contain the living cells and are thus able to react onto external stimuli. Therefore, they have the potential to repair themselves upon damage or form materials with locally defined microstructures and architectures. - Chemistry, Composite Materials, Microbiology
- Bachelor Thesis, Internship, Master Project (D-MATL), Master Thesis, Semester Project
| Optoacoustic (OA) imaging is a hybrid imaging method that enables deep tissue imaging with a high spatial resolution by combining optical illumination with ultrasound detection. The goal of this student project is to devise a parallel HW accelerator and explore different HLS code optimizations to achieve the best performance for OA image reconstruction on an FPGA in real-time.
- Biomedical Engineering, Electrical and Electronic Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| This project aims to create a FPGA-based interface capable of streaming live data from a ETH-developed CMOS biosensor and monitor neuroactivity and cell cultures in real time - Biomechanical Engineering, Electrical Engineering
- Master Thesis, Semester Project
| Our lab offers several master projects. Interested students can choose between projects associated with:
(1) Smooth Muscle Cell Characterization and Functional Assays (2) Therapies and Biomarkers in Prostate Cancer
(3) Understanding Immunosuppression in the Prostate Cancer Microenvironment
(4) Investigating the Effects of Oncogene Addiction on Prostate Cancer Metastasis
| This project aims at the development of a software for simulating light propagation over short distances, a necessary tool to achieve accurate measurement of oxygen saturation in tissue using compact devices. - Biomedical Engineering
- Bachelor Thesis, Master Thesis, Semester Project
| The uprise of consumer-grade fitness trackers has opened the doors to long-term activity monitoring in the wild in research and clinics. However, Fitbit does not identify napping episodes shorter than 90 minutes. Hence, there is a need to establish a robust algorithm to detect naps. - Artificial Intelligence and Signal and Image Processing, Biomedical Engineering, Biosensor Technologies, Electrical and Electronic Engineering
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis
| This research aims to advance biohybrid robotics by integrating living biological components with artificial materials. The focus is on developing computational models for artificial muscle cells, a critical element in creating biohybrid robots. Challenges include modeling the complex and nonlinear nature of biological muscles, considering factors like elasticity and muscle fatigue, as well as accounting for fluid-structure interaction in the artificial muscle's environment. The research combines first principle soft body simulation methods and machine learning to improve understanding and control of biohybrid systems. - Biological Mathematics, Biomechanical Engineering, Biophysics, Mechanical Engineering, Modeling and Simulation, Robotics and Mechatronics, Simulation and Modelling
- Bachelor Thesis, Master Thesis, Semester Project
| Recent years have seen accelerated tree mortality due to heat and drought, with varying responses across tree species. Understanding the physiological mechanisms leading to mortality is critical, particularly in response to drought-induced stress. This study aims to assess the correlation between tree ring growth patterns and remote-sensing-based vegetation indices to examine changes in tree health across Switzerland over three decades. By integrating tree-ring-based measurements and multispectral Landsat time series data, this approach will help define species-specific mechanisms of tree mortality and improve forest health monitoring. - Environmental Sciences, Forestry Sciences, Landscape Ecology
- ETH Zurich (ETHZ), Master Thesis, Semester Project
| We are offering multiple projects in the cleanroom with focus on gratings for x-ray application, this includes lithography and etching.
If you would like to do a project in a cleanroom do not hesitate to contact us under: bryan.benz@psi.ch - Biomedical Engineering, Interdisciplinary Engineering, Medical Physics
- ETH Zurich (ETHZ), Master Thesis, Semester Project
| The StrongAge Dataset, collected over one year, provides a rich data repository from unobtrusive, contactless technologies combined with validated mood and cognition questionnaires. This project aims to uncover digital biomarkers that can transform elderly care, addressing critical research questions related to sleep, cognition, physical activity, and environmental influences. - Biomechanical Engineering, Signal Processing
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Lab Practice, Master Thesis, Semester Project, Student Assistant / HiWi
| Experimental neurobiology: cognitive-behavioural investigations using touch-screen platform. This would suit a wide variety of students interested in hands on behavioural neurobiology experience. - Biology, Central Nervous System, Health, Clinical and Counselling Psychology, Mental Health, Neurocognitive Patterns and Neural Networks
- Master Thesis
| We aim to explore a range of cognitive impairments associated with various psychiatric and metabolic disorders in mice. Our goal is to identify the critical neural pathway connecting the hypothalamus to subcortical areas, which plays a key role in certain cognitive deficits. This project seeks not only to deepen our comprehension of the brain's intricate operations but also to lay the groundwork for precise therapeutic approaches. We will employ advanced technologies, including optogenetics, fiber photometry, and behavioral assessments, to achieve these objectives.
- Computational Structural Biology, Neurosciences
- Master Thesis
| The blood-brain barrier (BBB) restricts drug delivery to the brain, complicating the treatment of Alzheimer's disease. Temporary and safe opening of the BBB is a critical step for improving therapeutic delivery. This project focuses on developing hardware for BBB opening under optoacoustic imaging guidance, along with algorithms for monitoring using optoacoustic and magnetic resonance imaging. Key tasks include designing a focused ultrasound transducer, developing a precise positioning system for mouse brain navigation, characterizing the setup through phantom experiments, optimizing imaging reconstruction algorithms, and participating in preclinical studies with healthy and diseased mice. - Biomedical Engineering, Interdisciplinary Engineering, Medical Physics, Neurosciences
- Master Thesis
| This project aims to advance super-resolution imaging techniques, specifically localization optoacoustic tomography (LOT), for optimal imaging of the mouse brain. LOT allows for angiographic imaging beyond the acoustic diffraction limit, enabling blood velocity measurements and oxygen saturation quantification, which enhances understanding of microvascular dynamics and disease. Key tasks include designing hardware for scanning the mouse brain, developing biocompatible particles for in vivo tracking of blood vessels, creating algorithms for accurate blood flow velocity measurement, and implementing AI-based methods for efficient super-resolution imaging. The project also involves participation in experiments with healthy and disease mice. - Artificial Intelligence and Signal and Image Processing, Biomaterials, Interdisciplinary Engineering
- Master Thesis
| The aim of the project is to investigate the benefits, requirements and drawbacks of physics informed neural networks in the context of personalised cardiac and cardiovascular models - Biomechanical Engineering, Clinical Engineering, Computation Theory and Mathematics, Fluidization and Fluid Mechanics, Neural Networks, Genetic Alogrithms and Fuzzy Logic, Simulation and Modelling
- Master Thesis
| The project focuses exploiting generative AI to build synthetic numerical phantom for cardiac anatomy and function suitable for representing population variability. - Biomechanical Engineering, Information, Computing and Communication Sciences
- Master Thesis
| Foam Additive Manufacturing (FAM) integrates 3D printing with physical blowing agents (PBAs) to produce lightweight, porous structures. The extrusion process, which involves a polymer-PBA solution, is critical for foam formation [1]. Bubble nucleation and growth occur due to rapid pressure drops and temperature changes within the extruder nozzle. - Biology, Chemistry, Engineering and Technology, Information, Computing and Communication Sciences
- Bachelor Thesis, Master Thesis, Semester Project
| In this project, you will work on the design and development of a micro-/nanomanipulator that is integrated into a cutting-edge single-molecule sensor. This system will enable precise positioning of the sensor chip and dynamic size control of the nanopore, critical for detecting protein modifications of varying sizes. This project offers an excellent opportunity for students interested in nanotechnology, hardware development, and biomolecular analysis to gain interdisciplinary experience and make meaningful contributions to advancing nanopore sensing technology. - Biomedical Engineering, Biosensor Technologies, Computer Hardware, Nanotechnology
- Bachelor Thesis, Master Thesis, Semester Project
| The Biomaterials Engineering (BME) group of Professor Xiao-Hua Qin is hiring an ERC-funded PhD student in tissue microfabrication. - Biomedical Engineering, Materials Engineering, Mechanical and Industrial Engineering
- ETH Zurich (ETHZ), PhD Placement
| This thesis aims to design a pool of virtual-reality based rehabilitation tasks for simultaneous motor-cognitive rehabilitation for stroke patients - Behavioural and Cognitive Sciences, Biomedical Engineering, Electrical and Electronic Engineering, Information, Computing and Communication Sciences, Medical and Health Sciences
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| This project endeavors to explore the dynamic interplay among calcium ions, bone graft substitutes, and resident immune cells in both orthotopic and ectopic environments, employing advanced ratiometric imaging techniques. - Biomaterials, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| The quantification of optoacoustic (OA) signals is hindered by the non-uniform distribution of optical fluence within biological tissues. Such variability compromises the accuracy of OA-based measurements and limits their clinical translational potential. Estimating light fluence distribution, however, is not straightforward due to complex tissue heterogeneities. To address this challenge, we have developed a hybrid imaging platform capable of concurrently acquiring MRI and OA data. By leveraging the anatomical information from MRI, we can accurately localize and characterize tissues, thereby overcoming positioning uncertainties and enabling robust fluence estimation. We are currently seeking a motivated student to implement these MRI-based fluence correction strategies to restore OA images of the mouse brain. - Biomedical Engineering, Medical Physics, Neurosciences
- Master Thesis, Semester Project
| Advancements in sensor technology, low-power mixed-signal/RF circuits, and Wireless Sensor Networks (WSNs) have enabled the creation of compact, cost-effective solutions for healthcare applications. A notable development in this field is the Body Sensor Network, which is designed to monitor the human body for healthcare purposes.
- Biomedical Engineering, Electrical and Electronic Engineering
- Bachelor Thesis, Internship, Semester Project
| Cryogenic transmission electron microscopy (Cryo-
TEM) requires precise control of vibration
dampening to maintain imaging quality, particularly
in the 20-50 Hz frequency range. Conventional
vibration dampening approaches often struggle
with achieving the required precision and
adaptability for such specialized equipment. This
project focuses on the topological optimization of
vibration dampening components using lattice
structures, advanced CAD tools (e.g., Fusion360),
and AI-based design methodologies, validated through Laser Powder Bed Fusion (L-PBF)
manufacturing. - Architecture, Urban Environment and Building, Biology, Chemistry, Earth Sciences, Education, Engineering and Technology, Information, Computing and Communication Sciences, Mathematical Sciences, Medical and Health Sciences, Physics
- Bachelor Thesis, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| This project focuses on design and implementation of a Quality Management System (QMS) for the production of PCR diagnostic devices and cartridges. The primary goals include developing and implementing high-level Standard Operating Procedures (SOPs), establishing robust Quality Control (QC) processes in manufacturing, and designing comprehensive training programs for staff.
The project aims to ensure consistent product quality, regulatory compliance, and operational efficiency, contributing to the delivery of reliable and high-performing diagnostic solutions. - Biomedical Engineering, Industrial Biotechnology and Food Sciences, Industrial Engineering, Quality Assurance, Traceability and Metrological Chemistry, Quality Management, Safety and Quality
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Wearable, wirelessly connected sensors have become a common part of daily life, evolving step by step from their roots in sports and fitness to play a pivotal role in shaping the future of personalized healthcare. A key challenge in this evolution is designing devices that are unobtrusive, highly integrated, and energy efficient. These design requirements inherently demand smaller batteries, which must also support the significant power consumption of wireless communication interfaces. Capacitive Human Body Communication (HBC) offers a promising, power-efficient alternative to traditional RF-based communication, enabling point-to-multipoint data and energy exchange.
By using the conductive properties of the human body, a privacy-preserving wireless personal body area network (WBAN) can be created. Several low-power sensors such as ECG-tracker and insulin pumps can act as leaf devices, sending personal data to a body-central gateway, such as a smartwatch that further processes the data and establishes a connection to the cloud.
. - Biomedical Engineering, Electrical Engineering
- Biomedical (PBL), Energy Harvesting (PBL), Firmware (PBL), Machine Learning (PBL), Master Thesis, Microcontroller (PBL), PCB Design (PBL), Semester Project, Software (PBL), Wearables (PBL)
| Shape memory polymers (SMPs) are advanced materials capable of returning to their original shape when exposed to external stimuli such as heat or stress. Lactide copolymers, derived from renewable resources, are particularly attractive for SMP applications due to their tunable mechanical properties, thermal responsiveness, and biocompatibility. Optimizing precipitation-based processing techniques is critical to unlocking the full potential of lactide copolymers for advanced applications. - Agricultural, Veterinary and Environmental Sciences, Architecture, Urban Environment and Building, Biology, Chemistry, Earth Sciences, Education, Engineering and Technology, Information, Computing and Communication Sciences, Mathematical Sciences, Medical and Health Sciences
- Bachelor Thesis, Collaboration, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| Selective Laser Sintering (SLS) is a versatile additive manufacturing process that creates complex components by fusing powdered materials layer by layer. This project focuses on optimizing SLS parameters for polyhydroxyalkanoates (PHA), a biodegradable thermoplastic derived from renewable resources. PHA is of great interest due to its biodegradability and potential applications in sustainable manufacturing. - Agricultural, Veterinary and Environmental Sciences, Architecture, Urban Environment and Building, Biology, Chemistry, Earth Sciences, Engineering and Technology, Information, Computing and Communication Sciences, Mathematical Sciences, Medical and Health Sciences
- Bachelor Thesis, Collaboration, ETH Zurich (ETHZ), Internship, Master Thesis, Semester Project
| Selective Laser Sintering (SLS) is a versatile additive manufacturing technique used to produce components by fusing powder materials layer by layer. This project focuses on the SLS processing of cerium oxide (ceria) for applications in carbon dioxide (CO2) capture. Ceria is a promising material in this domain due to its redox properties and potential for use in thermochemical cycles for CO₂ conversion and storage. However, optimizing its SLS processing parameters to ensure high-quality functional parts remains a challenge. - Agricultural, Veterinary and Environmental Sciences, Architecture, Urban Environment and Building, Behavioural and Cognitive Sciences, Biology, Chemistry, Earth Sciences, Economics, Education, Engineering and Technology, Information, Computing and Communication Sciences, Medical and Health Sciences
- Bachelor Thesis, Collaboration, ETH Zurich (ETHZ), Master Thesis, Semester Project
| In this project, you will have the opportunity to contribute to the development and optimization of a single-molecule sensor designed for the detection, identification, and analysis of important biomolecules such as DNA and proteins. The sensor technology is built upon the principles of microfluidics, nanofabrication, and machine-learning data analysis. It is an excellent fit for students who possess skills and a strong interest in these fields and are eager to engage in an interdisciplinary project with significant potential impact. - Biology, Chemistry, Engineering and Technology, Medical and Health Sciences, Physics
- Master Thesis
| The development of advanced drug formulations is a cornerstone of pharmaceutical innovation, directly influencing therapeutic efficacy, patient outcomes, and market success. Achieving optimal drug absorption and bioavailability remains one of the most significant challenges in formulation design, particularly for oral and parenteral delivery systems. Addressing this challenge is critical for advancing scientific understanding and also for accelerating drug discovery and reducing time-to-market for new therapies.
This Master’s thesis project aims to develop an advanced cell culture assay to model drug absorption, providing a scientifically robust and commercially valuable platform for drug screening and optimizing novel drug formulations. By bridging gaps in current drug screening methodologies, this project will contribute to innovation in drug delivery technologies and enhance competitive positioning in the growing global market for pharmaceutical solutions. - Biochemistry and Cell Biology, Biomedical Engineering, Biotechnology, Chemical Engineering, Industrial Biotechnology and Food Sciences, Macromolecular Chemistry, Medical Biochemistry and Clinical Chemistry, Medicine-general, Microbiology, Pharmacology and Pharmaceutical Sciences
- Master Thesis
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