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The project focuses on the development of novel drug delivery systems with a focus on creating technologies that will help people with difficult diseases or improve quality of life. The project involves the development of novel mechanical delivery mechanisms for different drug compounds. Innovations in this space can improve adherence to drug regimens and even reduce side-effects by creating well controlled drug release dosages over time. The ideal candidate will be eager to learn and work in a multidisciplinary project that involve aspects of mechanical engineering, material science, chemical engineering, bio-analytics, and bioengineering. This merger of engineering disciplines makes for an interesting learning experience that goes beyond the typical classroom and more into the world of translational and applied engineering and science. - Biomedical Engineering, Chemical Engineering, Materials Engineering, Mechanical and Industrial Engineering
- Bachelor Thesis, Internship, Master Thesis
| In this project, you will be at the forefront of developing a new microrobotic system based on focused ultrasound trapping to treat ischemic strokes. In recent years, the development of microrobots has emerged as a promising frontier in precision medicine. These miniature robotic agents hold tremendous potential, yet their successful validation in vivo and their translation into clinical applications have encountered significant challenges. A primary impediment lies in the intricate task of precisely releasing therapeutic agents at the target environment. Previous approaches mainly made use of photocleavable links to release bound drug molecules at the target are. Unfortunately, light-based approaches often fall short in penetrating deep into tissue limiting the applicability in real medical scenarios. On the other hand, drug release via acoustic methods such as ultrasound has seen promising advancements by the use of bubbles or liposomes. However, our current microrobots rely on focused ultrasound trapping-based navigation and optoacoustic or ultrasound imaging. The occurring pressures in this method limit the use of bubbles or liposomes since they tend to collapse in this scenario. We are therefore searching for motivated students, who like to work on new concepts for the drug release in microrobots navigated via focused ultrasound. - Biochemistry and Cell Biology, Biotechnology, Chemical Engineering, Chemistry, Medical Biochemistry and Clinical Chemistry, Pharmacology and Pharmaceutical Sciences
- Bachelor Thesis, Internship, Lab Practice, Master Thesis, Semester Project
| This project investigates the integration of real-time computer vision capabilities into modern video see-through head-mounted displays (VST-HMDs). Using the Android Debugging Bridge (ADB), the study aims to develop a prototype for achieving object tracking, image registration, and other vision-based applications on Quest 3. Leveraging the computational power of a connected PC, the project explores advanced uses of VST technology, contributing to augmented reality (AR) innovations with applications such as diminishing reality or visual search. - Virtual Reality and Related Simulation
- Bachelor Thesis, ETH Zurich (ETHZ), Semester Project
| Robots have become increasingly advanced recently, capable of performing challenging tasks such as taking elevators and cooking shrimp. Moreover, their ability to accomplish long-horizon tasks given simple natural language instructions is also made possible by large language models. However, with this increased functionality comes the risk that intelligent robots might unintentionally or intentionally harm people based on instructions from an operator. On the other hand, significant efforts have been made to restrain large language models from generating harmful content. Can these efforts be applied to robotics to ensure safe interactions between robots and humans, even as robots become more capable? This project aims to answer this question.
- Engineering and Technology, Information, Computing and Communication Sciences
- Master Thesis, Semester Project
| The goal of this project is to apply LLMs to teach the ANYmal robot new low-level skills via Reinforcement Learning (RL) that the task planner identifies to be missing. - Intelligent Robotics
- Master Thesis
| This study investigates depth perception with virtual and real objects using video see-through (VST) and optical see-through (OST) head-mounted displays (HMDs). By comparing devices like Meta Quest 3, Pico 4, and HoloLens 2, the research explores how humans perceive spatial depth in mixed reality (MR) scenarios. Through Unity-based application development and user studies, the work evaluates depth perception differences and provides insights for advancing MR technology. - Virtual Reality and Related Simulation
- Bachelor Thesis, ETH Zurich (ETHZ), Semester Project
| The remarkable complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space. To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cellular nanomechanics such as tension forces and bioelectromagnetics) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
In this framework we are investigating the unacknowledged key role of Desmoglein 3 (Dsg3) as a receptor involved in mechanosensing, capable of initiating a signaling response in the transcellular communication network, which results in stem cell fate conversion, plasticity and tissue repair.
Our goal is to apply innovative Fluidic Force Microscopy to measure altered biophysical parameters upon disruption of Dsg3 transadhesion such as cell stiffness, cell-cell adhesion, cell surface charges and electric potentials. Together with the University of Bern and University of Lübeck we are further investigating how these biophysical changes relate to transcriptomic, epigenomic and proteomic response circuits to ultimately infer biophysical and biochemical circuits involved in Dsg3 signaling.
- Biochemistry and Cell Biology, Biomedical Engineering, Medical and Health Sciences, Physics
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| The remarkable complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space. To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cellular nanomechanics such as tension forces and bioelectromagnetics) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
In this framework we are investigating the unacknowledged key role of Desmoglein 3 (Dsg3) as a receptor involved in mechanosensing, capable of initiating a signaling response in the transcellular communication network, which results in stem cell fate conversion, plasticity and tissue repair.
Our goal is to apply innovative Fluidic Force Microscopy to measure altered biophysical parameters upon disruption of Dsg3 transadhesion such as cell stiffness, cell-cell adhesion, cell surface charges and electric potentials. Together with the University of Bern and University of Lübeck we are further investigating how these biophysical changes relate to transcriptomic, epigenomic and proteomic response circuits to ultimately infer biophysical and biochemical circuits involved in Dsg3 signaling.
- Biochemistry and Cell Biology, Biomedical Engineering, Medical and Health Sciences, Physics
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| Our team develops novel Aerial Robots that are able to autonomously manipulate and perform work in flight. In this thesis, we would like to explore the learning of task-specific policies for manipulation in flight.
- Intelligent Robotics
- Master Thesis
| Recent research has expanded the investigation of spontaneous fluctuations in the BOLD fMRI signal from the brain to the spinal cord. The vast majority of the studies have focused on the cervical cord, neglecting the lumbar cord which is involved in lower limb control as well as bladder, bowel, and sexual function. In a previous project, we demonstrated the presence of resting-state networks in the lumbar cord. Now, we aim to investigate the reliability of these resting-state networks within and across scans. Another goal is to improve the processing of the BOLD fMRI data, which requires an in-depth comparison of different denoising strategies and exploring their impact on reliability. To achieve these goals, the Master's student will have access to existing resting-state BOLD fMRI data and will also have the opportunity to expand the dataset by acquiring additional data. - Medical Biotechnology, Neurology and Neuromuscular Diseases, Neurosciences, Radiology and Organ Imaging, Rehabilitation Engineering
- Master Thesis
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