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The Functional Materials Laboratory (FML) of ETH Zürich is a group performing world-class research in a wide variety of fields, from nanoparticle chemistry to chemical device development. We are designing and developing innovative solutions for a wide range of applications with a cost-effective approach and short time-to-result. - Analytical Biochemistry, Chemistry, Engineering and Technology, Medical Biochemistry: Nucleic Acids
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| The Functional Materials Laboratory (FML) of ETH Zürich is a group performing world-class research in a wide variety of fields, from nanoparticle chemistry to chemical device development. We are designing and developing innovative solutions for a wide range of applications with a cost-effective approach and short time-to-result. - Biomedical Engineering, Chemical Engineering, Computer Hardware, Electrical and Electronic Engineering, Manufacturing Engineering, Mechanical and Industrial Engineering
- Internship, Lab Practice, Master Thesis, Semester Project
| Several projects:
1. Optical improvements and geometrical optimization of our newly developed detection module
2. Design of a new detection module for multiplex PCR
3. Design and construction of an innovative DNA-extraction device
4. Surface coatings strategies for digital PCR - Biomechanical Engineering, Engineering/Technology Instrumentation, Interdisciplinary Engineering, Manufacturing Engineering, Materials Engineering, Mechanical Engineering
- Bachelor Thesis, Course Project, Lab Practice, Master Thesis, Semester Project
| You can design and procure a new PCB to drive our innovative medical device that can make advanced PCR diagnostics possible within minutes. - Aerospace Electrical Systems, Automotive Engineering, Electrical Engineering, Mechanical and Industrial Engineering
- Bachelor Thesis, Collaboration, Course Project, ETH Organization's Labels (ETHZ), Internship, Lab Practice, Master Thesis, Semester Project, Student Assistant / HiWi
| Design effort and the associated costs are key factors which are limiting the adoption of additive manufacturing in industrial applications. One approach to tackle this problem is the use of automated design tools, which reduce the manual design effort to achieve manufacturable designs. In current research at pdz, we have been working on developing an automated design workflow for hydraulic manifolds. Several steps in the process chain have been tackled so far. - Mechanical Engineering
- Master Thesis, Semester Project
| Gold nanoparticles (NPs) are widely used materials for imaging techniques and drug delivery owed to their unique electrical, optical and chemical properties as well as their biocompatibility in human cells [1]. These applications however, require gold-NP suspensions that are stable in biological environments. Previous studies showed that attachment of a polyethylene glycol (PEG) layer onto gold-NPs and addition of human serum albumin induced formation of stable and ordered self-assemblies in biological solutions [2]. The questions that we seek to answer are: can we control and modulate the size, shape and ordering of these gold-NP-protein assemblies and, how does their self-assembled structure change once they are brought into more complex biological environments like cells or soft tissue?
[1] Sperling, Ralph A., et al. "Biological applications of gold nanoparticles." Chemical Society Reviews 37.9 (2008): 1896-1908.
[2] Iranpour Anaraki, Neda, et al. "In‐situ Investigations on Gold Nanoparticles Stabilization Mechanisms in Biological Environments Containing HSA." Advanced Functional Materials 32.9 (2022): 2110253.
- Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Clinical Pharmacology and Therapeutics, Colloid and Surface Chemistry, Condensed Matter Physics-Structural Properties, Electronmicroscopy, Xray Crystallography
- Internship, Master Thesis, Semester Project
| This project explores leveraging video object segmentation methods for 3D volumetric scene segmentations. The goal is to segment objects from videos and bridge the inferred masks with a volumetric reconstruction and segmentation system to recover the 3D structure and semantics of a scene. - Computer Graphics, Computer Vision, Intelligent Robotics, Photogrammetry and Remote Sensing
- Semester Project
| In this project, you will design a passive tangential flow filtration module in combination with a set of electrodes to continuously remove particles from the microfiltration membrane - Electrical Engineering, Fermentation, Biotechnology and Industrial Microbiology, Fluidization and Fluid Mechanics, Heat and Mass Transfer Operations, Mechanical Engineering, Membrane and Separation Technologies
- Master Thesis, Semester Project
| We use state-of-the-art 3D high-resolution imaging to study the properties of nanoscopic structures in bone. This project combines microCT imaging with advanced computational modelling and bone biology to advance our understanding of the mechanisms that lead to bone loss due to aging and disease. - Biomechanical Engineering, Image Processing, Radiology and Organ Imaging, Software Engineering
- Master Thesis, Semester Project
| Are you interested in a project on antibody secretion in cancer?
We are currently offering a project for interested Bachelor/Project/Internship students with background/interest in Biology, Biochemistry, Immunology or Molecular Biology interested in a project at the cross-section of microfluidics and antibody secretion.
Project Scope: In this study, we aim to investigate the complex relationship between antibody secretion of TAA- and self-specific B cells in a mouse model system. Using customized single-cell antibody secretion assays, we will characterize ASCs from murine breast tumor models from in- and exfiltrates based on their frequency, cellular functions, activity (secretion rate) as well as specificity and affinity towards TAAs and closely related self-specific antigens (Eyer K. Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring, 2017).
Tasks of your project:
Currently we are establishing an assay setup to detect tumor-associated antigen libraries. Student tasks will involve setting up of microfluidic based- antibody secretion assay for validation of antigen libraries using anti-tumor antibodies and checkpoint-inhibitor proteins. In detail, tasks will involve antibody calibration against specific antigens prominent in tumor and tumor libraries. Validation of assay against different isotype specific probes using anti-tumor IgM, IgA and IgG antibodies.
Goal:
A strong interest in technical challenges around microfluidics and a willingness to learn about biological systems are required. All new techniques will be taught thoroughly, and all steps and results will be discussed in detail with your supervisor. However, the ability to work and think independently is expected. The goal is for you to learn all essential basics and then be able to assess and suggest the next project steps.
If you are interested and enjoy working in an innovative environment at the cross-section of microfluidics and single cell assays for B cells, you are welcome to apply. Students with background in life-science engineering, immunology and/or biochemistry are welcome. - Biochemistry and Cell Biology, Genetic Immunology, Microbiology
- Bachelor Thesis, ETH Organization's Labels (ETHZ), Internship, Semester Project
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