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Augmented Reality (AR) has great potential to enhance assembly tasks for different scenarios and for people with various backgrounds. However, recent studies suggest that AR can sometimes slow down assembly. Thus, further research on the efficiency of AR-assisted tasks is needed. This project is based on existing work [1], where AR technology from incon.ai™ has been employed in the Compressed Earth Block (CEB) dwelling assembly [2]. - Mechanical and Industrial Engineering
- Bachelor Thesis, ETH Zurich (ETHZ), Semester Project
| We are looking to hire a talented and hardworking student to work on some components of our innovative Polymerase Chain Reaction (PCR) devices. - Engineering and Technology
- Bachelor Thesis, Collaboration, Internship, Lab Practice, Master Thesis, Semester Project, Student Assistant / HiWi
| Geothermal energy will be one of the most important assets to solve the world’s energy problems in the future. High Speed Rock Drilling (HSRD), a Swiss company, has been developing and testing an efficient process for deep drilling down to 10 km. - Mechanical and Industrial Engineering
- Master Thesis
| Approximately 1 out of 8 men worldwide will be diagnosed with prostate cancer (PCa) during their lifetime, making PCa the leading tumor type in male cancer patients. Localized PCa has a very high survival rate in patients. However, this survival rate sharply drops after the onset of metastasis, which is also the primary cause of mortality in PCa patients. Fascinatingly, in various tumor models, the primary tumor actively alters the microenvironment of distant organs beforehand, preparing a favorable niche for disseminated circulating tumor cells (CTCs) to graft and colonize with greater ease once they are in circulation. These hospitable microenvironments are termed pre-metastatic niches (PMNs) and are critical for overt metastasis formation. At present, PMN generation and its implications in PCa are poorly understood. Therefore, investigating how the PCa PMN unfolds will give us a deeper understanding of the biology of metastasis and lead to the discovery of novel drug targets essential for tailoring treatments for patients at higher risk of PCa metastasis and reducing tumor-related mortality.
Hence, in this project, students will aim to work on a series of in vivo experiments to help establish a preclinical model of metastasis formation in PCa. Primary work will include assistance with animal experiments (subcutaneous and intravenously injected tumors). Experience with extracellular vesicle isolation, Flow cytometry, PCRs, Simple Westerns, and CRISPR-CAS9 molecular editing will come with the project. - Biology, Medical and Health Sciences
- Master Thesis
| There are 300 known diseases that arise from haploinsufficiency (i.e. heterozygous mutations). A recent study reported that the number can be even higher (up to 3000 genes) that display signs of haploinsuffeciency (Collins et al, Cell, 2023). Why heterozygous mutations in some genes cause disease while others do not? Dosage compensation implies increased expression levels of the unaffected allele. In this project, we aim to investigate the extent to which dosage compensation occurs in respond to heterozygous mutations in mammalian systems using high throughput CRISPR screens coupled to single cell RNA sequencing. The project will also aim to investigate the role of the recently discovered Transcriptional Adaptation phenomenon (El-Brolosy et al, Nature, 2019) on dosage compensation, in addition to exploring therapeutic strategies for haploinsufficiency disorders that aim to enhance dosage compensation - Animal Physiology-Cell, Animal Physiology-Systems, Cell Physiology, Databases and Ontologies, Gene Expression, Gene Therapy, Genetic Development (incl. Sex Determination), Genetic Technologies: Transformation, Site-directed Mutagenesis, etc., Medical Biochemistry: Nucleic Acids, Medical Biotechnology, Medical Genetics, Other, Population and Ecological Genetics, Quantitative Genetics, Sequencing and Genomics, Systems Biology and Networks, Therapies and Therapeutic Technology
- Internship, Master Thesis, Semester Project
| We are looking for bachelor / master students to work part time to support the development of robotic platforms and assist with the preparations and execution of the Robotics Summer School taking place from 29 June through 5 July 2024. - Engineering and Technology
- Student Assistant / HiWi
| Moldable hydrogels found increasing popularity and have been used as injectable or extrudable materials in biomedical and industrial applications. This is mainly due to their ability to flow under applied stress (shear-thin) and reform a stable network (self-heal). To modify the mechanical properties of the dynamic polymer networks, nanoparticles can be added, which additionally can broaden the scope of their applications. The so-called polymer–nanoparticle (PNP) hydrogels represent a unique, tunable and versatile class of dynamic nanocomposite materials that form via reversible interactions between polymer chains and nanoparticles. However, the formation of PNP hydrogels is restricted to specific interactions between selected polymers and nanoparticles, resulting in a limited range of mechanical properties. - Characterisation of Macromolecules, Composite Materials, Organic Chemical Synthesis, Polymers, Supramolecular Chemistry, Synthesis of Macromolecules
- Internship, Master Thesis
| In addition to non-covalent structures, mechanically interlocked molecules are being increasingly explored such as in the case of a “rotaxane” using cyclic molecules as building blocks. This supramolecular structure is obtained by penetrating the cavity of a cyclic molecule with a linear molecule. Hence. the cyclic molecule can rotate and slide along the linear one. While, this feature has been applied to molecular shuttles and artificial muscles, recent studies have revealed that polymer materials using PRx exhibit superior mechanical strength. Additionally, upon application of stress to the networks, macrocyclic jamming leads to strain-stiffening behavior. Hence, applications of PRx to materials are highly desirable. - Characterisation of Macromolecules, Organic Chemical Synthesis, Polymers, Supramolecular Chemistry, Synthesis of Macromolecules
- Internship, Master Thesis
| In this project, we aim to study the effect of the network’s architecture in continual learning, with a specific focus on the effect of scaling it to large width and depth, and their interplay with other architectural components such as residual connections. - Artificial Intelligence and Signal and Image Processing
- Master Thesis, Semester Project
| In this project, we aim to develop a depth completion framework based on the anisotropic diffusion prior. - Computer Vision, Engineering/Technology Instrumentation, Geomatic Engineering, Pattern Recognition
- Master Thesis
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