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The remarkable complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space. To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cellular nanomechanics such as tension forces and bioelectromagnetics) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
In this framework we are investigating the unacknowledged key role of Desmoglein 3 (Dsg3) as a receptor involved in mechanosensing, capable of initiating a signaling response in the transcellular communication network, which results in stem cell fate conversion, plasticity and tissue repair.
Our goal is to apply innovative Fluidic Force Microscopy to measure altered biophysical parameters upon disruption of Dsg3 transadhesion such as cell stiffness, cell-cell adhesion, cell surface charges and electric potentials. Together with the University of Bern and University of Lübeck we are further investigating how these biophysical changes relate to transcriptomic, epigenomic and proteomic response circuits to ultimately infer biophysical and biochemical circuits involved in Dsg3 signaling.
- Biochemistry and Cell Biology, Biomedical Engineering, Medical and Health Sciences, Physics
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| The remarkable complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space. To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cellular nanomechanics such as tension forces and bioelectromagnetics) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
In this framework we are investigating the unacknowledged key role of Desmoglein 3 (Dsg3) as a receptor involved in mechanosensing, capable of initiating a signaling response in the transcellular communication network, which results in stem cell fate conversion, plasticity and tissue repair.
Our goal is to apply innovative Fluidic Force Microscopy to measure altered biophysical parameters upon disruption of Dsg3 transadhesion such as cell stiffness, cell-cell adhesion, cell surface charges and electric potentials. Together with the University of Bern and University of Lübeck we are further investigating how these biophysical changes relate to transcriptomic, epigenomic and proteomic response circuits to ultimately infer biophysical and biochemical circuits involved in Dsg3 signaling.
- Biochemistry and Cell Biology, Biomedical Engineering, Medical and Health Sciences, Physics
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| As the main interface between interior and exterior environments, facades hold great potential to support the decarbonization of the building sector, while providing high visual and thermal comfort levels. The Solar Simulator and climatic chamber at the Zero Carbon Building Systems Lab [3] offer the opportunity to test and analyze the performance of envelope components, supporting the development of new facade system. After the completion of a first calibration phase, the lab infrastructure shall now be extended to a validated experimental setup for measuring solar gains, heat and light transmission through 1:1 scale facade components. The establishment of testing protocols and their validation is essential to enable the use of the laboratory infrastructure for future research projects. This thesis will develop a validated setup for measuring the angle-dependent solar, optical and thermal exchanges through facade systems. - Building Science and Techniques
- ETH Zurich (ETHZ), Master Thesis
| Driver state detection systems will become mandatory in many countries in this decade. In this thesis, you will use a unique multi-sensor dataset with 55 drivers collected by us in a in a real car on a test track to develop a ML drunk driving detection algorithm. - Engineering and Technology, Information, Computing and Communication Sciences, Mathematical Sciences
- Master Thesis
| Integrating wind energy into Switzerland’s future energy system remains a complex challenge, with optimal use of available potential in an integrated system still underexplored. This project aims to enhance wind energy assessments by incorporating spatial-temporal wind potential into energy system modeling and analyzing its role in Switzerland’s energy transition, including social aspects. - Engineering and Technology, Information, Computing and Communication Sciences
- Master Thesis
| Laser ablation is mainly driven by the so-called laser-matter interaction. Especially for hard-to-machine materials like ceramics, which are gaining increasing attention in technical applications, the ablation phenomenon must be fully understood and controlled to achieve precise and selective material removal while maintaining material integrity. These materials have outstanding properties for a plurality of applications in industry; however, one is faced with the issue of finding a suitable manufacturing technique. Brittleness, hardness, and their tendency to crack lead to complications that could be addressed by the implementation of laser technology. However, experimental approaches alone are not expedient to fully handle and understand the complex phenomenon of laser ablation of ceramic multi materials. This is the motivation for introducing the first steps of simulating laser-matter interaction in multi-material ceramics within this project. - Manufacturing Engineering
- Bachelor Thesis, Internship, Master Thesis, Semester Project
| Quality requirements or non-functional requirements (NFR) are frequently described from the perspective of an organization that requires a software system to address a specific problem and achieve organizational goals. This approach is business-oriented and primarily reflects business goals. However, to design a user-centric system, the goals should be considered beyond the interests of a single organization and accurately reflect the perspective of users instead.
- Software Engineering
- Master Thesis
| To protect from chemical, biological, radioactive, and nuclear (CBRN) contaminants, disposable coveralls are used as personal protective clothing (PPC). In addition to its protective nature, PPC affects heat dissemination from the body, resulting in increased heat strain, which might result in reduced working performance. Therefore, new clothing material developments aim to reduce thermal load while maintaining a protective nature. We conduct a wearing trial in collaboration with an industrial partner to investigate the impact of different types of protective coveralls on heat strain during exposure to warm conditions, including resting phases and physical activity. - Exercise Physiology, Human Biophysics, Physiology, Systems Physiology, Textile Technology
- Internship, Lab Practice, Master Thesis, Semester Project
| The Swiss Energy Strategy 2050 aims to achieve zero net emissions target as of 2050. The four leading Swiss research institutes — Paul Scherrer Institute (PSI), Swiss Federal Laboratories for Materials Science and Technology (EMPA), Swiss Federal Institute for Forest, Snow and Landscape Research (WSL), and Swiss Federal Institute of Aquatic Science and Technology (EAWAG)—are at the forefront of this en-deavour. In the context of the SCENE project, these institutes are collaboratively developing science-based roadmaps that outline the anticipated pathways to attain net-zero emissions before 2040. The tran-sition to net zero requires a multifaceted approach, encompassing technological advancements, con-sumption reductions, and market-based mechanisms for emission compensation and reduction. An es-sential component of this transition is a comprehensive CO2 emission-related cost analysis. This analysis will evaluate the financial implications of shifting energy technologies, reducing consumption, and imple-menting market-based emission compensation and reduction strategies. - Earth Sciences, Economics, Engineering and Technology, Policy and Political Science
- ETH Zurich (ETHZ), Master Thesis
| Nanoparticles will be drawn out from dopant-supersaturated metal oxides, with tunability in their distribution and size. The catalytic performances of the nanoparticle catalysts will be closely examined - Chemical Engineering, Chemistry of Catalysis, Inorganic Chemistry, Materials Engineering, Sensor (Chemical and Bio-) Technology
- Bachelor Thesis, Internship, Lab Practice, Master Thesis, Semester Project, Summer School
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