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Parkinson’s disease is one of the most common neurodegenerative movement disorders affecting over 10 million people worldwide. Symptoms like impaired gait and postural instability can cause falls and highly impair patients’ mobility. The consequences of falls include fractures, hospital admissions, loss of independence, fear of falls, social isolation and early mortality. Falls are cited as one of the worst aspects of PD and unfortunately few efficacious interventions are available. - Engineering and Technology, Medical and Health Sciences
- Master Thesis, Semester Project
| The field of image restoration is continually evolving with the introduction of advanced deep learning models capable of tackling increasingly complex restoration tasks. The use of foundation models, which are pre-trained on diverse data before being fine-tuned for specific tasks, has demonstrated considerable promise in various domains of artificial intelligence. This proposal aims to develop a new foundation model for image restoration by incorporating the state-space model and enhancing it with text prompt capabilities. This approach will allow the model to perform targeted restorations based on descriptive textual prompts, significantly improving the precision and quality of the restoration process. - Computer Vision
- Collaboration, ETH for Development (ETH4D) (ETHZ), Master Thesis
| Scanning ion conductance microscopy (SICM) is the non-contact SPM technology to image live cells based on glass capillaries with a nanometric aperture. It applies a voltage and measures the ionic current flowing through the pipette above the sample in the buffer solution: the recorded current represents the feedback signal to measure the topography of the sample. In collaboration with Prof. Fantner at EPFL, this project aims to assemble a state of the art high-speed SICM to enable time-resolved live cell imaging. - Biomedical Engineering, Electrical and Electronic Engineering, Mechanical Engineering, Nanotechnology, Signal Processing
- Bachelor Thesis, Course Project, ETH Zurich (ETHZ), Lab Practice, Master Thesis, Summer School
| What about implantable self-powering devices to monitor biophysical signals at nanoscale? As a part of the interdisciplinary frontier between material science and new biomedical applications, being able to monitor biological or physical markers and signals, allows for a better treatment from both the diagnostic and healing point of view. Among them, biocompatible and non-intrusive wearable monitoring devices, which are so flexible to adhere perfectly to biological tissue, and even to cells like neurons, gain increasing interest. However, fabricating the devices and the electrodes at nano/microscale remains a challenge.
FluidFM is a force-controlled nanopipette, a versatile tool also for 2D patterning and 3D printing in liquid environment, opening the opportunity to manufacture the devices at the sub-micron scale.
We are going to create the devices and electrodes depositing conductive polymers with the FluidFM and then to perform the opportune characterization. - Electrical and Electronic Engineering, Materials Engineering, Medical and Health Sciences, Physics
- Master Thesis
| Pemphigus vulgaris (PV) is a unique group of autoimmune diseases. Researches have demonstrated that antibody-induced disruption of Dsg3 transadhesion initiates a signaling response in basal keratinocytes followed by loss of tissue integrity. The complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space.
To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cell topography and bioelectricity) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
Together with the University of Bern and University of Lübeck, we aim to utilize the tools to study the topography and electrophysiology (cell potential, ion channel recording, localized ion detection, charges) of HPEK cells (human primary keratinocytes cells) to unravel the signaling pathways of the disease. We utilize optical imaging (fluorescence dyes) and biosensing tools (including the state of the art hs-SICM and electrical FluidFM setup) to study HPEK cells upon desmosome disruption.
- Biology, Biomedical Engineering, Chemistry, Electrical and Electronic Engineering, Interdisciplinary Engineering, Medical and Health Sciences
- Bachelor Thesis, Lab Practice, Master Thesis, Semester Project, Summer School
| Reinforcement learning (RL) can potentially solve complex problems in a purely data-driven manner. Still, the state-of-the-art in applying RL in robotics, relies heavily on high-fidelity simulators. While learning in simulation allows to circumvent sample complexity challenges that are common in model-free RL, even slight distribution shift ("sim-to-real gap") between simulation and the real system can cause these algorithms to easily fail. Recent advances in model-based reinforcement learning have led to superior sample efficiency, enabling online learning without a simulator. Nonetheless, learning online cannot cause any damage and should adhere to safety requirements (for obvious reasons). The proposed project aims to demonstrate how existing safe model-based RL methods can be used to solve the foregoing challenges. - Engineering and Technology
- Master Thesis
| Drying (e.g. Pasta drying) is the most energy intensive process step, sometimes taking up more than 50% of the total energy consumption of a plant. Superheated steam drying could present an energy efficient alternative to classical hot-air drying systems used today. This new technology could have a massive impact on the carbon-footprint and sustainability of food-drying; making it a highly future-oriented and potentially impactful innovation. - Interdisciplinary Engineering, Manufacturing Engineering, Mechanical and Industrial Engineering
- ETH Zurich (ETHZ), Master Thesis, Semester Project
| The objective of this project is to create a comprehensive robotic platform capable of autonomously administering injections into the human eye. The project includes mechanical design, motion planning, and the implementation of a force control algorithm. - Mechanical and Industrial Engineering
- Bachelor Thesis, ETH Zurich (ETHZ), Master Thesis, Semester Project
| In this project, we propose a real-time sensorized hand-exoskeleton that combines the exosuit and the sensory feedback based on TENS systems. The integrated robotic system will be able to provide the user with assisted grasping force control via exo and with fine grip-force feedback. - Peripheral Nervous System, Rehabilitation Engineering, Therapies and Therapeutic Technology
- Master Thesis
| The project consists in assessing the degree to which our perception of natural texture is shaped by the mechanics of the skin. We have implemented an approach, developed by Ted Adelson at MIT (GelSight), that consists of fabricating a gel whose material properties match those of the skin and then imaging (using a laser profilometer) the pattern of deformation on the surface of the gel that is produced when pressed against the surface. We can then estimate how the skin would be deformed by any given texture using this approach and assess whether we can better predict from these patterns of skin deformation the responses of tactile nerve fibers to that texture and the perception thereof. - Biomedical Engineering, Central Nervous System, Sensory Systems
- Master Thesis
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